As a leading (R)-2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of (R) 2- [[[3-methyl-4- (2,2,2-trifluoroethoxy) -2-pyridyl] methyl] sulfinyl] -1H-benzimidazole?
(This is the name of a complex organic compound, which needs to be resolved and described in ancient classical Chinese)
I look at this " (R) -2- [[[3-methyl-4- (2,2,2 -trifluoroethoxy) -2 -allyl] methyl] sulfinyl] -1H -benzimidazole" Naming, when its chemical structure is described as follows.
Its core is the ring system of 1H-benzimidazole, which is the root of the structure of organic compounds. At the 2nd position of the benzimidazole ring, there is a substituent attached. This substituent is connected by a sulfinyl group. One end of the sulfinyl group is connected to the benzimidazole ring, and the other end is connected to a complex group.
In this complex group, [[3-methyl-4- (2,2,2-trifluoroethoxy) -2-allyl] methyl] is the main body. Among them, "3-methyl", that is, there is a methyl branch at the 3rd position of the main chain; "4 - (2,2,2-trifluoroethoxy) ", indicating that the 4th position of the main chain is connected with a 2,2,2-trifluoroethoxy group, which is composed of three fluorine atoms connected to ethoxy; "2-allyl" means that there is an allyl structure at the 2nd position of the main chain, and the allyl group has active chemical properties. And this monolithic group is connected to the sulfinyl group through the methyl group, and finally forms the unique structure of this organic compound with the benzimidazole ring. In this way, it is the chemical structure analysis of " (R) -2- [[3-methyl-4- (2,2,2-trifluoroethoxy) -2 -allyl] methyl] sulfinyl] -1H -benzimidazole".
What are the physical properties of (R) 2- [[[3-methyl-4- (2,2,2-trifluoroethoxy) -2-pyridyl] methyl] sulfinyl] -1H-benzimidazole?
(R) 2- [[[3-methyl-4- (2,2,2-trifluoroethoxy) -2-pyridyl] methyl] sulfinyl] -1H-benzimidazole has the following physical properties:
This compound is mostly solid at room temperature, due to the existence of various interaction forces between molecules, such as van der Waals force and hydrogen bond, which promote the close arrangement of molecules. Its melting point is also an important physical property, and accurate determination of the melting point is helpful to distinguish the purity and crystal form of the compound. However, due to the many different groups in the molecular structure, the intermolecular forces are complex, so its melting point will fluctuate according to specific experimental conditions and purity.
In terms of solubility, in view of the fact that there are both hydrophobic groups such as methyl in the molecular structure, and polar parts such as trifluoroethoxy, sulfinyl and nitrogen atoms on the benzimidazole ring that can form hydrogen bonds with the solvent, the solubility in organic solvents is relatively unique. In polar organic solvents such as ethanol and acetone, the solubility is exhibited by the interaction between polar groups and the solvent to form hydrogen bonds. In non-polar organic solvents such as n-hexane, the solubility is poor due to hydrophobic action.
In addition, the compound has a certain refractive index, which reflects the ratio of the propagation speed of light in it to the propagation speed in vacuum, which is closely related to the electron cloud distribution and molecular structure of the molecule. Due to its specific atomic composition and connection method, it is endowed with a unique electron cloud distribution, which determines the corresponding refractive index value, which is also of great significance for the identification and purity analysis of compounds.
At the same time, the density of the substance is also a key physical property, and the density depends on the relative molecular mass of the molecule and the packing density of the molecule in the solid or liquid state. Due to the complex structure of the molecule, the number of atoms is large, the relative molecular mass is large, and the intermolecular forces make the molecule accumulate in a specific way, so it has the corresponding density value. This value has applications in chemical production and quality control.
What is the main use of (R) 2- [[[3-methyl-4- (2,2,2-trifluoroethoxy) -2-pyridyl] methyl] sulfinyl] -1H-benzimidazole?
(R) - 2 - [[3-methyl-4 - (2,2,2-trifluoroethoxy) - 2-pyridyl] methyl] sulfinyl] - 1H-benzimidazole This compound is a key compound in the field of medicinal chemistry. Its main use is in the preparation of proton pump inhibitors.
Guanfu proton pump inhibitors are effective in the treatment of gastric acid-related diseases, such as gastric ulcer, duodenal ulcer and reflux esophagitis. These diseases are often caused by imbalance in gastric acid secretion and damage to the gastric and esophageal mucosa. And (R) - 2 - [[3-methyl-4 - (2,2,2-trifluoroethoxy) - 2-pyridyl] methyl] sulfinyl] - 1H-benzimidazole can specifically act on the proton pump of gastric parietal cells, namely H +/K + -ATPase. It combines with the specific part of this enzyme to effectively inhibit gastric acid secretion, thereby relieving gastric acid erosion on mucosa, promoting ulcer surface healing, and relieving patients' pain.
Furthermore, in the process of drug development, this compound has better biological activity and pharmacokinetic properties than other isomers due to its unique stereochemical structure, that is, (R) configuration. Researchers can develop new proton pump inhibitors with better efficacy and less side effects through fine modification and optimization of the structure of this compound, opening up broader prospects for the treatment of gastric acid-related diseases. Therefore, (R) - 2 - [[3-methyl-4 - (2,2,2-trifluoroethoxy) - 2 -pyridyl] methyl] sulfinyl] - 1H -benzimidazole is of great significance in the field of medicine.
What are the preparation methods of (R) 2- [[[3-methyl-4- (2,2,2-trifluoroethoxy) -2-pyridyl] methyl] sulfinyl] -1H-benzimidazole?
To prepare (R) -2- [[3-methyl-4- (2,2,2-trifluoroethoxy) -2-pyridyl] methyl] sulfinyl] -1H-benzimidazole, the method is as follows:
First take an appropriate amount of 2-chloromethyl-3-methyl-4- (2,2,2-trifluoroethoxy) pyridine hydrochloride and place it in the reaction vessel. In addition, prepare a solution containing thiol salt, slowly pour it into the above container containing pyridine hydrochloride, and stir the reaction at moderate temperature. The purpose of this step is to make the two undergo a nucleophilic substitution reaction. The sulfur atom in the thiol salt nucleophilically attacks the chloromethyl group of the pyridine hydrochloride salt, and the chlorine atom leaves to obtain an intermediate containing the thioether structure.
Then, the obtained thioether intermediate is taken out and transferred to another clean reaction vessel. Adding a specific oxidant, such as m-chloroperoxybenzoic acid, etc., controls the reaction temperature and time to make the thioether oxidize, and accurately generates (R) -2- [[3-methyl-4- (2,2,2-trifluoroethoxy) -2-pyridyl] methyl] sulfinyl] structure. This oxidation step needs to be carefully controlled, because the amount of oxidant, reaction temperature and duration all have a great influence on the configuration and purity of the product.
Subsequently, the above sulfinyl-containing intermediate is mixed with o-phenylenediamine in a suitable solvent, and an appropriate amount of catalyst, such as p-toluenesulfonic acid, is added to heat the reflux reaction. In this reaction process, the amino group of o-phenylenediamine undergoes a condensation reaction with the sulfinyl intermediate. After cyclization and other steps, the target product (R) - 2 - [[3-methyl-4 - (2,2,2-trifluoroethoxy) -2 -pyridyl] methyl] sulfinyl] -1H -benzimidazole is finally generated. After the reaction, a series of post-processing operations such as cooling, separation and purification can obtain a pure target product. The whole preparation process requires strict control of the reaction conditions at each step to ensure high yield and high purity of the product.
What is the market outlook for (R) 2- [[[3-methyl-4- (2,2,2-trifluoroethoxy) -2-pyridyl] methyl] sulfinyl] -1H-benzimidazole?
Today, there are (R) -2- [[[3-methyl-4- (2,2,2-trifluoroethoxy) -2 -allyl] methyl] sulfinyl] -1H -benzothiazole, and its market prospects are related to many aspects.
This compound is used in the field of medicine, or due to its unique chemical structure, it has potential biological activity, and can be used as a lead compound for drug development. For example, because it contains fluorine atoms, fluorine atoms have high electronegativity, which can change the lipophilicity and metabolic stability of compounds, or be used to develop antiviral and anti-tumor drugs. If the research and development goes well, it is expected to occupy a place in the market for the treatment of related diseases and bring huge profits to pharmaceutical companies. < Br >
In the field of materials science, or because of its structural characteristics, it has made a name for itself in organic optoelectronic materials. If its structure can be modified to regulate its electron transport and optical properties, it can be used to manufacture organic Light Emitting Diodes (OLEDs) or solar cell materials. With the rapid development of electronic equipment and renewable energy industries, if it can be applied in this field, the market demand will be considerable.
However, its marketing activities also face challenges. The synthesis process is complex, the cost is high, and large-scale production and market application are restricted. And the market competition is fierce, and it needs to compete with similar or functionally similar compounds. If we want to explore a broad market prospect, we need researchers to overcome the synthesis problem, reduce costs, and conduct in-depth research on its performance and application in order to stand out in the market and gain wide application and recognition.
