Propargyl 1H-imidazole-1-carboxylate

Propargyl-1H-imidazole-1-carboxylic acid esters are very important chemical substances in the field of organic synthesis. Their main uses are wide, let me tell you one by one.
In the field of pharmaceutical chemistry, propargyl-1H-imidazole-1-carboxylic acid esters are often used as key intermediates. Because of its unique chemical structure, it can participate in many complex reactions to construct molecular structures with biological activities. For example, it can be introduced into the molecular framework of drugs through specific chemical reactions, so that drugs can obtain specific pharmacological activities, such as antibacterial, antiviral, and antitumor effects. This is due to the structural characteristics of the substance, which can interact with specific targets in organisms and interfere with the metabolic process of pathogens or the proliferation mechanism of tumor cells.
In the field of materials science, it also plays an important role. It can be used to prepare functional polymer materials. By polymerizing with other monomers, propargyl-1H-imidazole-1-carboxylic acid ester structural units are introduced into the polymer chain, giving the material unique properties. Such as improving the thermal stability and mechanical properties of the material, or giving the material the ability to absorb and recognize specific substances. This is because the active groups in its structure can interact with other substances, thereby improving the overall properties of the material.
In addition, in the study of organic synthetic chemistry, propargyl-1H-imidazole-1-carboxylic acid esters are used as reaction substrates to participate in the exploration of various novel chemical reactions. Chemists have expanded the methodology of organic synthesis by optimizing their reaction conditions and designing reaction paths, and synthesized organic compounds with novel structures and unique properties, which have contributed to the development of organic chemistry. In short, propargyl-1H-imidazole-1-carboxylic acid esters have indispensable locations and wide application prospects in many fields due to their unique structure and reactivity.

Propargyl-1H-imidazole-1-carboxylic acid ester, this is an organic compound. Its physical properties are quite important and are related to many practical applications.
Let's talk about the appearance first. Under normal temperature and pressure, propargyl-1H-imidazole-1-carboxylic acid ester is mostly colorless to light yellow liquid, clear and transparent, like clear water, but it contains a unique chemical structure, which is very different from water. Looking at it, it can be distinguished from its color and texture, which is the key to the preliminary understanding of its properties.
Talking about the melting point, this compound has a low melting point, about -20 ° C. Just like thin ice in winter, it melts when it is warm. The lower melting point indicates that the intermolecular force is not strong. In a relatively low temperature environment, that is, it changes from solid to liquid. This property can be used as a flux or participate in reactions that require low temperature melting operations in specific chemical reactions and material formulations.
In terms of boiling point, it is about 240-250 ° C. It requires a higher temperature to boil into a gaseous state, just like after a long time of suffering, it can be converted into rising steam. A higher boiling point means that it has good thermal stability and is not easy to evaporate and dissipate in high temperature environments. It can be used in high temperature reaction systems to provide protection for stable reaction.
Solubility is also an important physical property. Propargyl-1H-imidazole-1-carboxylic acid ester is soluble in a variety of organic solvents, such as common ethanol, acetone, dichloromethane, etc., just like fish entering water, it can mix with these solvents. This solubility is conducive to its use as a reactant or intermediate in organic synthesis, and it can achieve homogeneous reaction with the help of organic solvents to improve the reaction efficiency and selectivity.
The density is about 1.1-1.2 g/cm ³, which is slightly heavier than water. Like a stone sinking in water, it will slowly sink when placed in water. Density data is of great significance in the separation, storage and transportation of substances, and can be designed according to rational processes and packaging to ensure its safety and stability.
In addition, the compound is volatile to a certain extent. Although it is not as volatile as some low-boiling solvents, it will slowly emit into the air in an open environment. When using and storing, pay attention to this property to prevent its volatilization loss and potential harm to the environment and people.

To obtain the chemical synthesis of propynyl-1H-imidazole-1-carboxylic acid ester, the following method can be used.
First, 1H-imidazole is used with suitable protective reagents to protect the activity of imidazole from unnecessary side reactions in subsequent reactions. Commonly used protective groups, such as tert-butoxycarbonyl (Boc), etc., with suitable solvents, such as dichloromethane, and bases, such as triethylamine, are stirred at low temperature or room temperature to obtain protected imidazole derivatives. < Br >
times, take propargyl alcohol, and a suitable halogenating agent, such as thionyl chloride or phosphorus tribromide, under appropriate reaction conditions, convert the hydroxyl group into a halogen atom to obtain a propargyl halide. This reaction requires attention to the control of reaction temperature and reaction time to prevent over-halogenation or other side reactions.
Then, the protected imidazole derivative and propargyl halide are heated and stirred in the presence of a suitable base, such as potassium carbonate or sodium hydride, with N, N-dimethylformamide (DMF) or acetonitrile as a solvent. The function of the base is to capture the hydrogen on the imidazole nitrogen atom, make it a nucleophilic reagent, and undergo nucleophilic substitution reaction with the proparynyl halide to form a carbon-nitrogen bond between the proparynyl group and the imidazole.
After the reaction is completed, the protective group is removed by a suitable method. If a Boc protective group is used, acidic conditions can be used, such as treatment with an organic solvent solution of hydrochloric acid and gentle stirring, the protective group can be removed to obtain the target product proparynyl-1H-imidazole-1-carboxylic acid ester. Finally, the product is purified by means of column chromatography or recrystallization to obtain a high-purity target compound. The whole process requires attention to the precise control of the reaction conditions at each step, as well as the separation and identification of intermediates and products, in order to achieve the purpose of synthesis smoothly.

In today's world, it is not easy to know the price of "Propargyl+1H-imidazole-1-carboxylate" in the market. Looking at "Tiangong Kaiwu", in the past, the value of things was judged by their rarity, simplicity of workmanship, and wide and narrow use. However, this thing is a new creation today, and it is difficult to find its trace in the book.
Or it can be deduced. If its preparation requires rare materials and is difficult to mine, such as the ancient search for strange minerals in the deep mountains and valleys, its price will be high; if the preparation is exquisite and complicated, like the ancient casting of famous swords, after thousands of refinements, it is time-consuming and laborious, and the price is also high.
And if this material is widely used and indispensable in medicine, chemical industry and other industries, such as ancient salt and iron, which is related to people's livelihood, the price will be high. On the contrary, if the material is common, the system is simple, the use is limited, and the price should be low.
To get a price, you need to consult today's chemical material merchants, or visit chemical trading places, and observe changes in market supply and demand.

Propargyl-1H-imidazole-1-carboxylic acid esters have a wide range of application fields. In the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of new drugs. Because of its special chemical structure, it can precisely combine with specific targets in organisms, which helps to develop highly active and highly selective drugs, such as targeted therapeutic drugs for specific diseases, which is expected to bring light to the treatment of difficult diseases.
In the field of materials science, it also has extraordinary performance. It can participate in the preparation of polymer materials with special properties, giving materials unique chemical and physical properties. For example, to make it have excellent stability, thermal properties or optical properties, it is very useful in high-end fields such as aerospace and electronic devices, and contributes to material innovation.
In organic synthetic chemistry, this compound is an important building block for the construction of complex organic molecules. With its active reaction check point, through clever organic synthesis strategies, it can build diverse carbon-carbon and carbon-heteroatom bonds, expand the structural diversity of organic compounds, inject vitality into the development of organic synthetic chemistry, and promote the exploration and innovation of new reactions and methods.