prop-2-ynyl imidazole-1-carboxylate

Prop-2-ynyl + imidazole-1-carboxylate is a unique compound in the field of organic chemistry. Its main uses are quite extensive and it is of great significance in the field of organic synthesis.
In the process of organic synthesis, this compound often acts as a key intermediate. In terms of the structure of complex organic molecules, the unique reactivity of prop-2-ynyl and imidazole-1-carboxylate can initiate a variety of chemical reactions. The alkynyl group has electron-rich properties and can participate in reactions such as nucleophilic addition and cyclization, providing the possibility for the construction of carbon-carbon bonds and carbon-heteroatomic bonds. The imidazole-1-carboxylate part, due to the conjugated structure of the imidazole ring and the reactivity of the carboxylate, can interact with a variety of reagents, helping to form novel chemical bonds and expand the complexity of molecules.
In the field of pharmaceutical chemistry, such compounds have also emerged. Drug developers often use their unique structure and reactivity to design and synthesize lead compounds with specific biological activities. The imidazole ring structure is common in many bioactive molecules and is crucial for regulating the interaction between molecules and biological targets. The introduction of alkynyl groups not only adjusts the physical and chemical properties of molecules, such as lipophilicity, but also participates in high-efficiency reactions such as click chemistry, which facilitates the modification and optimization of drug molecules to enhance the efficacy of drugs and reduce side effects.
In the field of materials science, prop-2-ynyl + imidazole-1-carboxylate can be used as functional monomers or cross-linking agents. Alkynyl groups can introduce imidazole-1-carboxylate structures into polymer materials through polymerization or cross-linking reactions, imparting special properties such as ionic conductivity and biocompatibility to materials. For example, in the preparation of new electrolyte materials, the use of its structural characteristics is expected to improve the material's ability to transport ions, which can be applied to energy storage devices such as high-performance batteries.
In short, prop-2-ynyl + imidazole-1-carboxylate has shown important uses in many fields such as organic synthesis, medicinal chemistry and materials science due to its unique structure and diverse reactivity, providing many opportunities and possibilities for the development of related fields.

Prop - 2 -ynyl imidazole - 1 -carboxylate is an organic compound, and its physical properties are as follows.
From the perspective of this compound, at room temperature, it is mostly solid, because of its strong intermolecular forces. Its melting point is quite high. Due to the existence of multiple chemical bond interactions in the molecular structure, more energy is required to transform it from a solid state to a liquid state to overcome the attractive force between molecules.
As for solubility, the molecular structure contains both imidazole rings with a certain polarity and propargyl groups without polarity, so it is quite unique in organic solvents. In polar organic solvents, such as ethanol and acetone, it has a certain solubility, and its polar part can form intermolecular forces with polar solvent molecules, such as hydrogen bonds, van der Waals forces, etc., to help it disperse in the solvent; while in non-polar organic solvents, such as n-hexane and benzene, the solubility is low, because although the non-polar part and the non-polar solvent molecule have forces, the polar imidazole ring part is incompatible with the non-polar solvent, limiting the overall dissolution.
The density of this compound is greater than that of common organic solvents, which is caused by its molecular composition and the compactness of its structure. And its stability is good. The imidazole ring in the structure is aromatic, and the propargyl group is unsaturated, but it forms a certain conjugate system with the imidazole ring, which reduces the energy of the whole molecule and makes it more stable.
Its appearance is often white or off-white solid powder, which is caused by the molecular arrangement and the reflection and scattering characteristics of light. In summary, prop-2-ynyl imidazole-1-carboxylate exhibits the above various physical properties due to its unique molecular structure.

Prop-2-ynyl + imidazole-1-carboxylate is one of the organic compounds. This compound has unique chemical properties.
In its structure, the presence of prop-2-ynyl gives it certain reactivity. The carbon-carbon triple bond in the alkynyl group is active and prone to addition reactions. Such as addition with electrophilic reagents, new functional groups can be introduced at the triple bond, thereby expanding the chemical diversity of the molecule.
The imidazole-1-carboxylate part, the imidazole ring is aromatic, and the electron cloud distribution of the nitrogen atom is unique, so that it can participate in the reaction as an electron donor or receiver. And carboxylic acid ester groups can undergo common ester reactions such as hydrolysis and alcoholysis. In hydrolysis, under acid-base catalysis, ester bonds can be broken to form corresponding carboxylic acids and alcohols; when alcoholysis, it can exchange reactions with different alcohols to obtain new ester compounds.
This compound has a wide range of uses in the field of organic synthesis. Due to its structural properties, it can be used as a key intermediate to construct complex organic molecules through a series of reactions, providing an important foundation for research in pharmaceutical chemistry, materials science and other fields. Its unique chemical properties provide opportunities for chemists to explore novel reaction paths and develop new synthesis methods, promoting the continuous development of organic chemistry.

To prepare prop-2-ynyl + imidazole-1-carboxylate, follow the following ancient method.
First take imidazole-1-carboxylic acid, which is the key starting material. Dissolve it with an appropriate solvent, such as dichloromethane, to create a uniform liquid phase environment. Then, under mild stirring conditions, slowly add a suitable condensing agent, such as dicyclohexyl carbodiimide (DCC) or 1- (3-dimethylaminopropyl) - 3-ethyl carbodiimide hydrochloride (EDC · HCl). The action of this condensing agent is to activate the carboxylic group of imidazole-1-carboxylic acid to make it more reactive.
At the same time, prop-2-yn-1-ol is also dissolved in the same solvent and added dropwise to the above reaction system. Because the hydroxyl group of prop-2-yn-1-ol can be esterified with the activated carboxylic group, and then form prop-2-ynyl + imidazole-1-carboxylate. The reaction process needs to be closely monitored, and the consumption of raw materials and the production progress of products can be observed by thin layer chromatography (TLC).
When the reaction is almost complete, process the reaction mixture in an appropriate way. For example, the urea by-products generated by the reaction (if DCC is used) are filtered first, and then the filtrate is washed with dilute acid and dilute base in sequence to remove unreacted raw materials and impurities. Finally, dried with anhydrous sodium sulfate, distilled under reduced pressure to remove the solvent, and further purified by column chromatography, etc., to obtain a pure prop-2-ynyl + imidazole-1-carboxylate product. This synthesis method requires attention to the control of reaction conditions. The choice of solvent, the ratio of materials and the reaction temperature are all related to the yield and purity of the product.

Wuguan Ru asked "prop-2-ynyl + imidazole-1-carboxylate" in the market price range. This is a chemical term, which is a compound of propynyl imidazole-1-carboxylate. However, the market price varies depending on many factors such as quality, purity, supply and demand, and manufacturers.
If it is a high-purity scientific research-grade product, it is specially used for laboratory precision research, and the market demand is relatively stable. However, the preparation process is complicated, and delicate processes and strict conditions are required. The price must be high. It can reach hundreds of yuan per gram, or even more than 1,000 yuan, depending on the specific purity and requirements.
If it is industrial grade, the purity is slightly inferior, and it is used for large-scale industrial production. Due to the large amount of consumption, its price may be relatively easy. In kilograms, per kilogram or in the range of thousands of yuan. However, this is only a rough guess. The actual price should be consulted with chemical raw material suppliers, chemical reagent sales platforms, or industry experts to obtain the exact number. Because the chemical market conditions are changing, prices often fluctuate with changes in raw material costs, policies and regulations, and market supply and demand, it is difficult to give accurate and constant prices.