N-methoxy-1H-benzimidazole-2-carboxamide

N-methoxy-1H-benzimidazole-2-formamide, its chemical structure can be regarded as a combination of benzimidazole ring, formamide group and methoxy group.
The benzimidazole ring is a nitrogen-containing heterocyclic structure, which is fused by a benzene ring and an imidazole ring. This structure endows the compound with unique aromaticity and stability, which is common in many bioactive molecules and drugs. Formamide is attached to the 2-position of the benzimidazole ring. The amide group has a certain polarity and can participate in the formation of hydrogen bonds, which affects the physical and chemical properties and biological activities of compounds. In many drugs and bioactive substances, the amide bond is often a key structural unit, which can affect the interaction between molecules and the binding with biological targets. Methoxy is attached to the nitrogen atom, and methoxy is the electron supply group, which can change the electron cloud distribution of the benzimidazole ring, thereby affecting the reactivity and biological activity of the compound.
Overall, N-methoxy-1H-benzimidazole-2-formamide has a unique structure, and its various parts interact to give the compound specific physical, chemical and biological properties. It has attracted much attention in the fields of organic synthesis and medicinal chemistry, or has potential biological activities such as antibacterial, anti-inflammatory and anti-tumor, attracting researchers to explore its properties and applications in depth.

N-methoxy-1H-benzimidazole-2-formamide, this is an organic compound. It has a wide range of uses and is often a key intermediate in drug research and development. The structure of Gein-benzimidazole has unique biological activities and can interact with many biological targets in the body. By modifying N-methoxy and formamide groups, the physicochemical properties and biological activities of compounds can be adjusted to meet specific drug needs, such as anti-tumor, anti-viral and other drug creation.
In the field of materials science, it also has its uses. Due to its structural stability and functionality, it can be used to prepare materials with special properties, such as materials with fluorescent properties, to play a role in optical devices, sensors, etc. Due to its specific chemical structure, it may participate in material polymerization reactions and endow materials with new properties, such as improving material mechanical properties, thermal stability, etc.
In the agricultural field, it may be used as a potential pesticide active ingredient. Benzimidazole compounds have inhibitory effects on some crop diseases and insect pests, N-methoxy-1H-benzimidazole-2-formamide may be rationally designed and modified to develop into high-efficiency, low-toxicity and environmentally friendly pesticides to ensure crop growth and increase yield.

To prepare N-methoxy-1H-benzimidazole-2-formamide, the following method is often followed.
First take benzimidazole-2-carboxylic acid as the starting material, and heat it with sulfinyl chloride. After a reaction, the carboxyl group of benzimidazole-2-carboxylic acid is converted into acyl chloride to obtain benzimidazole-2-formyl chloride. This step requires attention to temperature control, and the amount of sulfinyl chloride should be accurate to promote smooth reaction and avoid the generation of impurities.
Dissolve the prepared benzimidazole-2-formyl chloride into an appropriate solvent, such as dichloromethane. In this solution, slowly add a salt of N-methoxylamine, such as N-methoxylamine hydrochloride. At the same time, add an appropriate amount of acid binding agent, such as triethylamine. The acid binding agent can remove the acid generated by the reaction and help the reaction proceed to the right. During the reaction, pay attention to stirring, so that the materials are evenly mixed, and the temperature should not be high or low, and it should be maintained within a certain range to facilitate the full reaction of the two, so that N-methoxy-1H-benzimidazole-2-formamide is produced.
After the reaction is completed, it is post-processed by the usual method. For example, first separate the liquid, discard the lower liquid, and take the upper organic phase. Wash the organic phase with an appropriate amount of water several times to remove unreacted salts and impurities. Then dry the organic phase with anhydrous sodium sulfate, filter out the desiccant, and spin to remove the solvent to obtain a crude product. The crude product can be refined by column chromatography or recrystallization, and a suitable eluent or solvent can be selected. After some operation, the heteroaryl is removed and pure, and the pure N-methoxy-1H-benzimidazole-2-formamide is finally obtained.

N-methoxy-1H-benzimidazole-2-formamide is an organic compound. Its physical properties are very important, which are related to the behavior and use of this substance in different scenarios.
First, the appearance of this compound is usually white to off-white crystalline powder. In this form, it is easy to handle and measure in many chemical operations and applications. The texture of the powder is delicate, laying the foundation for subsequent mixing, dissolution and other steps.
The melting point is about 150-155 ° C. As a key physical property of the substance, the melting point can help chemists determine its purity. If the melting point is in this range and the melting range is narrow, it often indicates that the purity of the compound is quite high; conversely, if the melting range is wide, there may be impurities.
In terms of solubility, N-methoxy-1H-benzimidazole-2-formamide is slightly soluble in water. This property shows that it is difficult to disperse in large quantities in aqueous systems, but its performance in organic solvents is different. It is soluble in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). In dichloromethane, due to the non-polarity of dichloromethane and the partial structure of the compound, it can be well dissolved, which provides convenience for extraction and reaction operation in organic synthesis; in DMF, with the strong polarity and good solubility of DMF, it can promote related reactions.
In addition, the density of the compound is about 1.32 g/cm ³. This property of density is of great significance in material storage, transportation, and the calculation of dosage when participating in the reaction. Knowing its density can accurately plan the size of the storage container to ensure transportation safety.
The physical properties of N-methoxy-1H-benzimidazole-2-formamide, such as appearance, melting point, solubility and density, play a decisive role in its application in chemical synthesis, drug development and other fields. Chemists need to design experiments and application plans according to their properties.

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