methyl 5-(diethoxymethyl)-1H-imidazole-4-carboxylate

Methyl 5- (diethoxy methyl) -1H-imidazole-4-carboxylic acid esters have a wide range of uses. In the field of medicine, it is often a key intermediate for the synthesis of special drugs. Due to its unique molecular structure, it can be derived from compounds with specific pharmacological activities through delicate chemical transformation, or it can be used for the treatment and prevention of diseases. For some difficult diseases, the drugs derived from it may play a miraculous role.
In the field of materials science, it also has potential uses. Or it can be used as a starting material for the preparation of special functional materials. Through chemical synthesis, the materials are endowed with special properties such as excellent stability and unique optical properties. For example, in the creation of specific optical materials, it can be used as a key building block to help achieve the required optical indicators.
In the field of organic synthetic chemistry, this compound is also an important building block. Chemists can modify and modify its structure to build more complex and diverse organic molecular structures, expand the variety and properties of organic compounds, and contribute to the development of organic synthetic chemistry.

There are various ways to prepare methyl 5- (diethoxy methyl) -1H-imidazole-4-carboxylic acid esters.
First, the corresponding imidazole derivative can be initiated. First, take a suitable imidazole compound, which has a structure or contains a modifiable check point, which can introduce diethoxy methyl and carboxylic acid methyl ester groups in subsequent reactions. Stepwise modification can be carried out through carefully selected reagents and reaction conditions. For example, imidazole and a reagent containing diethoxy methyl can be first introduced into the imidazole 5 position with nucleophilic substitution or a similar reaction mechanism under suitable base catalysis. The bases used, such as potassium carbonate and potassium tert-butyl alcohol, are reacted in suitable organic solvents such as N, N-dimethylformamide (DMF) and acetonitrile, and the temperature and reaction time are controlled to achieve good yields. After that, carboxyl methyl esterification is carried out for the imidazole 4 position. Carbon monoxide, methanol and a suitable catalyst system can be used to introduce carboxylic acid methyl ester groups at the 4 position through carbonylation reaction. This carbonylation reaction may require a metal catalyst such as a palladium-based catalyst, and a specific ligand is matched to improve the selectivity and efficiency of the reaction.
Second, the construction of an imidazole ring can also be started. Select raw materials containing suitable functional groups and construct an imidazole skeleton through cyclization reaction. For example, a compound containing an aldehyde group, an amino group, and an ester group is used to form an imidazole ring through a condensation cyclization process under acidic or basic catalytic conditions. In this process, the raw material molecules can be cleverly arranged to convert the aldehyde group into a diethoxy methyl group, while the original ester group remains at the 4 position, or the target carboxylic acid methyl ester structure can be obtained after a little modification. The reaction solvent or an alcohol solvent can be selected, and the reaction temperature is finely regulated according to the activity of the raw material and the reaction process.
Third, it can also be optimized and improved with the help of the synthesis ideas of similar compounds existing in the literature. With reference to the synthetic pathway of imidazole derivatives, adaptations were made in terms of group introduction, reaction sequence, reaction conditions, etc., to meet the synthesis requirements of methyl 5- (diethoxy methyl) -1H-imidazole-4-carboxylate. In this way, after many attempts and optimizations, an effective synthesis method of the target product can be obtained.

Methyl 5- (diethoxy methyl) -1H -imidazole-4 -carboxylic acid ester, this is an organic compound. Looking at its physical and chemical properties, under normal temperature and pressure, it is mostly in a solid state. However, due to the specific purity and crystal form, the appearance may vary slightly, or it is a white to off-white crystalline powder with a fine texture and a smooth feel to the touch.
In terms of its melting point, it is within a certain range, and this property is crucial for its identification and purity determination. Its boiling point also has a certain value, and under specific pressure conditions, a phase change will occur. The solubility of this compound in organic solvents is quite characteristic. It can be soluble in common organic solvents such as ethanol and acetone, but its solubility in water is relatively low. This difference in solubility has important implications for its separation, purification and application in specific reaction systems.
Its chemical properties are active, and the imidazole ring gives it a unique electron cloud distribution in its molecular structure, making it easy to participate in various chemical reactions. Diethoxy methyl group at the 5-position and carboxylic acid methyl ester group at the 4-position are both reactive activity check points. Hydrolysis can occur. Under acidic or basic conditions, carboxylic acid methyl ester groups are easily hydrolyzed to form corresponding carboxylic acids. At the same time, diethoxy methyl can undergo deprotection reaction under appropriate conditions, and then more active intermediates can be derived for the construction of more complex organic molecular structures. In the field of organic synthesis, with its unique physical and chemical properties, it is often used as a key intermediate, participating in the synthesis process of many drugs and functional materials. Using it as a starting material, through ingenious design of reaction routes, compounds with specific biological activities or material properties can be constructed.

I don't know the price range of "methyl 5- (diethoxymethyl) -1H-imidazole-4-carboxylate" in the market. The price of various substances in the market often changes with time, place, quality and supply and demand. The price of this compound varies greatly due to different uses and purity. For details, you can consult chemical reagent suppliers, such as Sinopharm Group Chemical Reagent Co., Ltd., search banner reagent network, etc., or search on the chemical product trading platform, and look at the quotations of different merchants to get the approximate price range.

Methyl 5- (diethoxymethyl) -1H-imidazole-4-carboxylic acid ester, this compound is used in many fields such as medicine and materials.
In the field of medicine, it is often a key intermediate in drug synthesis. The imidazole structure is crucial in many drug molecules, and drugs with different biological activities can be obtained by modifying the structure of the compound. For example, some imidazole drugs have antibacterial activity, which can act on specific targets of bacteria, interfere with the normal physiological process of bacteria, and achieve antibacterial effect; some have antiviral activity, which can inhibit virus replication. The ester group and diethoxy methyl group contained in the compound can be chemically converted to optimize the solubility, stability and bioavailability of drug molecules.
In the field of materials, this compound may be able to participate in the preparation of functional materials. Due to its unique electronic structure and coordination ability, imidazole rings can complex with metal ions to form metal-organic framework materials (MOFs). These materials have high specific surface area and regular pore structure, and exhibit excellent performance in gas adsorption and separation, catalysis, etc. For example, in gas adsorption, specific gas molecules can be selectively adsorbed; in catalytic reactions, it can provide an activity check point and accelerate the reaction process. In addition, it is introduced into the polymer material as a structural unit, which may endow the material with special properties, such as improving the thermal stability and mechanical properties of the material.