Methyl 5-amino-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylate

This compound Methyl 5 - amino - 4 - fluoro - 1 - methyl - 1H - benzimidazole - 6 - carboxylate, Chinese name 5 - amino - 4 - fluoro - 1 - methyl - 1H - benzimidazole - 6 - methyl carboxylate, its main use is often found in the field of pharmaceutical and chemical industry.
At the end of pharmaceutical development, it can participate in the construction of many drug molecules as a key intermediate. For example, in the development process of new antimicrobial drugs, by ingeniously modifying and derivatizing their structures, antimicrobial drugs with unique antimicrobial mechanisms, excellent antimicrobial activity and low drug resistance may be created. And in the exploration of anti-tumor drugs, it may also play a key role. By interacting with specific targets, it may interfere with the proliferation, differentiation and metastasis of tumor cells, providing a new opportunity for the innovation of anti-tumor drugs.
In the chemical industry, in the synthesis of functional materials, it can be integrated into polymer materials as a structural unit, giving materials special properties such as fluorescence and adsorption. For example, preparing adsorption materials with high selective adsorption capacity for specific substances, or fluorescent materials with specific photophysical properties, thus finding a place in environmental monitoring, chemical sensing and other fields. At the same time, in the production of fine chemicals, it can be used to synthesize additives with special functions, catalyst ligands, etc., to improve product performance and quality.

Methyl 5-amino-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylate, this is an organic compound. Its physical and chemical properties are quite important and are related to many fields of application.
First of all, the appearance is usually white to off-white crystalline powder, which is fine and uniform, and pure in appearance. This form is conducive to its operation and use in different scenarios, such as easy weighing, mixing, etc.
In terms of solubility, it shows a certain solubility in common organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF). Dichloromethane is a commonly used organic solvent and is well soluble with it, making it easy to participate in various reactions in the organic synthesis step. In water, its solubility is poor, and this characteristic is closely related to the molecular structure. The hydrophobicity of benzimidazole ring and methyl group in the molecule makes it difficult to dissolve in water with strong polarity.
Melting point is also a key physical property. After measurement, its melting point is within a specific range. This value provides an important basis for the purity identification of compounds. If the melting point deviates from the normal range, it may suggest that the purity of the compound is poor and mixed with impurities.
In terms of chemical properties, the amino group in the molecule has a certain alkalinity and can react with acids to form corresponding salts. This reaction property can be used to improve the solubility and stability of compounds and enhance their efficacy in drug synthesis. The carboxyl ester part can undergo hydrolysis reaction under specific conditions to generate corresponding carboxylic acids and alcohols. This hydrolysis reaction plays a key role in the metabolism and transformation of compounds in vivo or in specific chemical reaction systems. The introduction of fluorine atoms endows compounds with unique chemical activity, affects their electron cloud distribution and reactivity check point, and changes the reactivity and biological activity of the whole molecule. The benzimidazole ring is structurally stable and is also the active center of various chemical reactions. It can participate in many heterocyclic reactions, providing the possibility for further structural modification and derivatization.

To prepare methyl 5-amino-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylate, there are many common synthesis methods. First, fluorobenzoic acid derivatives can be started. First, fluorobenzoic acid is nitrified in an appropriate way to introduce the nitro group into the appropriate position. This step requires careful selection of nitrifying reagents and reaction conditions. For example, mixed acid (mixture of sulfuric acid and nitric acid) can be reacted at low temperature with moderate stirring to obtain nitro-substituted fluorobenzoic acid derivatives. Then, the nitro group is reduced, and the nitro group is converted into an amino group by the method of iron powder-hydrochloric acid system or catalytic hydrogenation to obtain 5-amino-4-fluorobenzoic acid derivatives. Then, it reacts with methylamine, uses an appropriate base as an acid binding agent, such as potassium carbonate, etc., and reacts in a suitable solvent (such as DMF, etc.) to introduce methyl groups at the benzene ring nitrogen atom to generate 5-amino-4-fluoro-1-methylbenzoic acid derivatives. Finally, the derivative is esterified with methanol catalyzed by concentrated sulfuric acid, heated and refluxed for a certain period of time to obtain methyl 5-amino-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylate.
Second, phthaleamine derivatives can also be used as starting materials. First, the phthaleamine derivative is reacted with fluorocarboxylic acids in the presence of a condensing agent, such as DCC (dicyclohexyl carbodiimide) and DMAP (4-dimethylaminopyridine) system, reacted in an organic solvent (such as dichloromethane) to form a benzimidazole ring. After that, the target product can also be obtained by nitrification, reduction, methylation and esterification according to the above-mentioned similar methods. During the reaction process, each step needs to pay attention to the control of reaction conditions, such as temperature, pH, reaction time, etc., to ensure the smooth progress of the reaction and improve the yield and purity of the product.

The market price of methyl 5-amino-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylate varies with supply and demand, quality, and provenance. Looking at the example of "Tiangong Kaiwu" in the past, the price of various materials often changes. This methyl 5-amino-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylic acid ester, if it is a common commercial product, the quality is medium and average, and in common markets, the price may range from a few yuan per gram to a few tens of yuan; if the quantity is large, it can be purchased in bulk, or it can be reduced to a few yuan per gram. However, if its quality is excellent and used in high-end fields such as special pharmaceutical research and development, the price will increase greatly, to more than 100 yuan per gram, or even higher. And if its source is rare and difficult to produce, its price should also be expensive. Therefore, in order to know the exact price, it is necessary to carefully examine the current market conditions, the number of purchases and the quality. There is no constant price in the market, and the actual price can only be obtained by observing the details.

Methyl 5-amino-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylic acid ester, the manufacturer of this substance is rarely well known in the world. However, in the fields of fine chemicals and pharmaceutical chemistry, there may be factories that are dedicated to research and precision manufacturing.
In the prosperous places where chemical raw materials are concentrated, such as the Yangtze River Delta and the Pearl River Delta, the chemical industry is prosperous, and there may be factories that can produce this substance. The factories there are exquisite skills and well-equipped, and they are leaders in chemical manufacturing.
Furthermore, there may be manufacturers overseas who are good at this field. In Europe and the United States, chemical research has a long history and a strong industrial base. There are many chemical companies that focus on the synthesis of heterocyclic compounds. Fine chemicals such as methyl 5-amino-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylic acid esters may be their production category.
If you want to know the exact manufacturer, you need to go deep into the hinterland of the chemical industry, check the chemical product directory and industry exhibition materials in detail, and communicate carefully with industry experts and experts to obtain the details. The chemical industry is secretive and complex, and many manufacturers focus on R & D and manufacturing, which may not be widely known. Only by carefully exploring can you get the truth.