Methyl 5-(4-broMo-2-chlorophenylaMino)-4-fluoro-1-Methyl-1H-benzo[d]iMidazole-6-carboxylate

This is related to the chemical structure of "methyl 5 - (4 - bromo - 2 - chlorophenylamino) - 4 - fluoro - 1 - methyl - 1H - benzo [d] imidazole - 6 - carboxylate". According to the chemical naming convention, the core structure of this name is a benzimidazole ring. The benzimidazole ring is formed by fusing a benzene ring with an imidazole ring. This structure is common in many drugs and bioactive molecules. < Br >
Among them, 1-methyl indicates that there is a methyl substitution at position 1 of the benzimidazole ring, which may affect the spatial structure and electron cloud distribution of the molecule, and then act on its physicochemical properties and biological activities. 4-fluorine shows that there is a fluorine atom at position 4 of the benzimidazole ring, and the fluorine atom has high electronegativity, which will affect the polarity and metabolic stability of the molecule.
Furthermore, 5- (4-bromo-2-chlorophenylamino) means that a substituent is connected at the 5th position of the benzimidazole ring, which is 4-bromo-2-chlorophenylamino. Bromine and chlorine atoms are both halogen elements, which are more electronegative and contribute to the lipophilic and electronic effects of the molecule. The presence of amino groups on the benzene ring can participate in hydrogen bond formation and other interactions, affecting the binding of molecules to targets.
Finally, methyl 6-carboxylate, that is, at position 6 of the benzimidazole ring, is connected to a methyl carboxylate group, which plays a certain role in the solubility and chemical stability of the molecule, and may also be used as an activity check point in certain reactions or metabolic processes.
In summary, the various substituents in the chemical structure of this compound interact with each other, jointly determining its unique physicochemical properties and potential biological activity.

This compound is named methyl 5- (4-bromo-2-chlorophenylamino) -4-fluoro-1-methyl-1H-benzo [d] imidazole-6-carboxylate. Its main uses are often found in the fields of medicinal chemistry and organic synthesis.
In medicinal chemistry, compounds with this structure are often studied in depth. Due to its unique benzimidazole structure and halogen atom substituent, it has potential biological activity. Scientists can modify and optimize its structure to explore its effect on specific biological targets, such as certain enzymes or receptors, in the hope of developing new drugs, or to study the mechanism of disease, to help drug development process.
In the field of organic synthesis, it is an important synthetic intermediate. With the halogen atom and amino group on the benzene ring, as well as the activity of benzimidazole ring and carboxyl ester, more complex compound structures can be constructed through a variety of organic reactions. For example, the nucleophilic substitution reaction of halogen atoms is used to react with various nucleophilic reagents to achieve structural expansion; through the hydrolysis and aminolysis of carboxyl esters, different functional groups are derived to synthesize compounds with diverse structures to meet the research and practical application needs of organic synthetic chemistry.

To obtain a method for the synthesis of methyl 5 - (4 - bromo - 2 - chlorophenamino) - 4 - fluoro - 1 - methyl - 1H - benzo [d] imidazole - 6 - carboxylic acid esters, the method can be as follows.
First take appropriate starting materials, such as benzimidazole compounds containing fluorine and methyl, and aniline derivatives containing bromine and chlorine. Mix the two with suitable organic solvents, such as dichloromethane, N, N - dimethylformamide, etc. < Br >
In the reaction system, add an appropriate amount of alkali, such as potassium carbonate, triethylamine, etc., to promote the reaction. The base can assist in activating the reactants, making them more prone to nucleophilic substitution reactions.
Control the reaction temperature, usually in the range from room temperature to heated reflux, depending on the specific situation. If the temperature is too low, the reaction rate is slow; if the temperature is too high, it may initiate side reactions.
When the reaction is carried out, continue to stir to allow the reactants to fully contact and accelerate the reaction process.
When the reaction reaches the expected level, it can be monitored by means of thin layer chromatography. After the reaction, use conventional separation and purification methods, such as column chromatography, recrystallization, etc., to obtain a pure target product. Column chromatography can use eluents of different polarities to separate the product and impurities; recrystallization is based on the difference in solubility of the product and impurities in different solvents to achieve the purpose of purification.
Through this step, methyl 5 - (4-bromo-2-chlorophenylamino) - 4-fluoro-1-methyl-1H-benzo [d] imidazole-6-carboxylic acid esters can be obtained. However, in practice, the reaction parameters need to be fine-tuned according to the specific experimental conditions and raw material characteristics to achieve the best effect.

This is methyl 5- (4-bromo-2-chlorophenylamino) - 4-fluoro-1-methyl-1H-benzo [d] imidazole-6-carboxylic acid ester. Its physical properties are as follows:
This substance is often in solid form, and its appearance may be white to off-white crystalline powder. This is caused by the interaction between atoms in its molecular structure to form a tight lattice arrangement. Powder form helps to increase its specific surface area and can better participate in the reaction or dispersion during the reaction or preparation process.
In terms of melting point, it is usually in a specific temperature range, about [X] ° C to [X] ° C. The melting point is determined by the intermolecular forces, such as hydrogen bonds, van der Waals forces, etc. The interaction between benzene rings, imidazole rings and various substituents in the molecule of this compound makes it necessary to destroy the crystal lattice with a specific energy to realize the transition from solid to liquid.
In terms of solubility, it has a certain solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). This is because these organic solvents can form similar intermolecular forces between the molecules of the compound, which is conducive to molecular dispersion. However, the solubility in water is very small. Due to the large number of hydrophobic groups in the molecular structure, the interaction with water molecules is weak, and it is difficult to overcome the hydrogen bonds between water molecules and disperse uniformly. The density of
is about [X] g/cm ³, and the density depends on the molecular weight and the way of molecular packing. The molecular weight of this compound increases due to the presence of bromine, chlorine, fluorine and other atoms, and the molecular arrangement is close, so it has a specific density value. In terms of stability,
is relatively stable under conventional conditions, but it needs to avoid light, high temperature and strong acid-base environment. Light may initiate electron transitions within molecules, resulting in structural changes; high temperature will increase molecular kinetic energy, making chemical bonds more susceptible to fracture; strong acid-base may react with certain groups in the molecule, changing its chemical structure.

Guanfu methyl 5 - (4 - bromo - 2 - chlorophenamino) - 4 - fluoro - 1 - methyl - 1H - benzo [d] imidazole - 6 - carboxylic acid ester This product has considerable market prospects.
In today's world, the field of pharmaceutical chemical industry is booming. Such compounds are often key intermediates for the creation of new drugs. In the process of drug development, its importance is self-evident. Taking the research and development of anti-cancer drugs as an example, many studies have focused on compounds containing such structures, hoping that they can inhibit the growth and proliferation of cancer cells. Due to the special substituents, such as bromine, chlorine, fluorine atoms and benzimidazole structures, they endow them with unique physicochemical and biological activities.
Furthermore, in the field of pesticides, such substances also have potential applications. They may exhibit good insecticidal and bactericidal properties. With their structural characteristics, they can accurately act on specific targets of pests or pathogens, and are more selective and environmentally friendly than traditional pesticides.
However, its market prospects are not smooth sailing. The high cost of research and development is a major challenge. From the synthesis and optimization of compounds to pharmacological and toxicological research, a lot of manpower, material and financial resources are required. And the approval process of new drugs is complicated and time-consuming, which is a factor restricting their rapid entry into the market.
In the chemical production process, environmental protection requirements are becoming increasingly stringent. It is also urgent to ensure that the synthesis process of such compounds is green and sustainable, and the impact on the environment is reduced. If we can properly address various challenges, solve the problems of research and development, cost and environmental protection, methyl 5 - (4 - bromo - 2 - chlorophenylamino) - 4 - fluoro - 1 - methyl - 1H - benzo [d] imidazole - 6 - carboxylic acid esters in the pharmaceutical and pesticide market, it will surely have great potential, shine and become an important boost for the development of the industry.