What is Histidine?

The author of "Heavenly Works" is the Ming Song Dynasty, and it is written by the star of the Ming Dynasty. It is a classic of science and technology. In today's words and histidine, this is the name of the Western language. In ancient times, it is important to cut and cut it. However, based on the principle of herbal medicine, it can be discussed for a while.

Histidine is one of the amino acids of the family. Amino acids are also the cornerstones of protein formation. Histidine is an important physiological process in biology, such as protein synthesis, enzyme activity, etc.

The ancient home, the importance of food and food. If you think of it in ancient times, you can think of it. The ancient herbal medicine contains a variety of materials, such as rice, and the human body has a large amount of energy. It contains a variety of ingredients, or it also has the effect of acid-like acid, which can benefit the body and increase the function of the internal organs. Another example is the essence, which has been used for a long time to prolong the body. The reason for its efficacy, or the generation of acid-like acid.

However, the ancient family has not been as good as today, and the molecular function and essence of acid cannot be clarified. In ancient times, it was necessary to study and observe more to identify the nature of food. Today's acid can be obtained by chemical synthesis or biological technology, and ancient natural things can be used to treat diseases. In other words, histidine is the amino acid, which is the name of this essence in ancient times. However, its role in human beings and the concept of life in ancient times may be similar.

What is the role of Histidine in living organisms?

Histidine is widely used and important in living organisms.

Histidine is one of the amino acids and has the properties of zwitterions. Because it contains amino and carboxyl groups, this structure enables it to be in different acid-base environments, either acidic or alkaline. It plays a great role in maintaining the acid-base balance in living organisms. Many biochemical reactions in the body need to be carried out smoothly within a specific pH. Histidine is like a guardian, ensuring the stability of the environment and paving the way for various biochemical reactions.

Furthermore, histidine is indispensable in protein synthesis. Proteins, the cornerstone of biology, shoulder the important tasks of catalysis, transportation, and structural support. Histidine is the unit of protein, which is arranged and combined in a specific sequence, giving the protein a unique three-dimensional structure and function. Without histidine, the integrity and functionality of the protein are severely damaged, and the growth, development, repair and other processes of organisms will also be blocked.

In terms of immune regulation, histidine also plays its role. The immune system is crucial to the body's resistance to external evil. Histidine may participate in the metabolism and signaling of immune cells, helping immune cells to accurately identify and eliminate pathogens, enhance the body's resistance, and protect the organism's health.

In addition, histidine metabolic derivatives, such as histamine, also have extraordinary performance in nerve conduction and vascular regulation. Histamine can affect the release of neurotransmitters, which is related to the perception, emotion and other activities of the organism. In blood vessels, it can cause blood vessels to expand or contract, regulate blood flow, and maintain the normal blood supply of various tissues and organs in the body.

In short, although histidine is small, all the things involved in the organism are related to the root of life. Without it, the harmony and order of the organism are difficult to exist.

What are the main sources of Histidine?

"Tiangong Kaiwu" says: "Husband histidine is an indispensable amino acid in the biological body. It comes from many sources and can be obtained from natural sources or artificially synthesized.

In natural sources, various protein foods are an important source of histidine. For example, lean meat, which is firm and rich in nutrients, can be decomposed by the digestive system to obtain histidine; or fish, which swim in rivers, lakes and seas, and the meat is tender, and also contains this amino acid. Beans, such as soybeans and mung beans, can also provide histidine to the human body after cooking or processing. In addition, milk and its products are rich in nutrients and play an important role in maintaining human health. They also contain histidine.

Furthermore, in the body, there is also a mechanism for synthesizing histidine by itself. Organisms use a series of complex biochemical reactions, using specific substances as raw materials, and under the catalysis of enzymes, gradually synthesize histidine to meet their own physiological needs.

As for the method of artificial synthesis, with the rise of science and technology, chemists use their wisdom and skills to simulate reactions in organisms or find another way to synthesize histidine from chemical raw materials through multiple processes. This is widely used in industrial production and medicine, which can make up for the lack of natural sources and meet the needs of all parties. "

What are the consequences of Histidine deficiency?

If there is a lack of histidine in the human body, the consequences are quite serious. Although the results of histidine deficiency are not accurately recorded in Tiangong Kaiwu, histidine has extraordinary effects on the human body in terms of medical science and human needs.

Histidine is one of the essential amino acids in the human body and participates in many important physiological processes. If histidine is missing, it will bear the brunt of protein synthesis. Proteins are the cornerstone of the human body and are indispensable for cell repair, growth and maintenance of normal function of the body. Histidine deficiency hinders protein synthesis, causing normal repair and growth of tissues and organs, such as muscle atrophy, skin relaxation and inelasticity, and delayed wound healing.

Histidine also plays a key role in the immune system. Its absence will weaken the function of the immune system, make the body's ability to resist pathogens decline, susceptible to various diseases, and difficult to recover after illness. Such as the evil of wind and cold is easy to invade the body, and the disease is lingering and difficult to cure.

The nervous system is also affected by it. Histidine participates in the synthesis of neurotransmitters. When it is absent, nerve signal transmission is disturbed, resulting in mental weakness, difficulty concentrating, memory loss, etc., which affects daily labor and life, such as difficulty in reading, literacy, and working and making a living.

Furthermore, histidine is essential for iron absorption and transportation. Lack of histidine hinders iron absorption, causing iron deficiency anemia, which makes people look yellow, dizzy, tired, and breathless when they move a little.

It can be seen that although histidine is small, it is related to the overall health of the human body. If it is missing, it is plagued with various diseases. It is necessary to pay attention to it and supplement it through a reasonable diet to ensure normal body function.

How to detect the amount of Histidine in the body?

To determine the content of Histidine in the body, you can follow the following methods.

One is a biochemical detection method. Take a blood sample or a urine sample, both of which can reflect the metabolism of amino acids in the body. Take high performance liquid chromatography (HPLC) as an example, this is a commonly used technique for analyzing amino acid content. The reason is that each component in the sample is repeatedly allocated between the stationary phase and the mobile phase. Due to the difference in the distribution coefficients of each component, its moving speed is different, and finally it is separated. After separation, the signal intensity of Histidine is measured by means of an ultraviolet detector or a fluorescent detector, and its content can be known by comparing it with the standard. There is also mass spectrometry (MS), which can accurately measure the molecular weight and structure of compounds. When combined with HPLC (HPLC-MS), it can increase the sensitivity and selectivity of detection, and accurately measure the content of Histidine in complex biological samples.

The second is the related pathway of gene detection. Although genetic detection does not directly measure the content of Histidine, its synthesis and metabolism are regulated by genes. Detection of relevant gene variants or expression levels can infer the metabolic status of Histidine in the body. For example, if the key genes involved in Histidine synthesis are mutated, or cause Histidine synthesis disorders, it is indirectly reflected in the content change. Polymerase chain reaction (PCR) can be used to expand specific gene fragments, and then sequencing technology can be used to analyze the genetic sequence to detect whether there is any mutation; or quantitative PCR can be used to measure gene expression.

Third, observe the physiological characteristics. Although it is not a precise quantitative method, the lack or excess of Histidine in the body can cause physiological abnormalities. Lack of it, or see growth retardation, weak immune function, skin and mucosal lesions, etc.; excess, or cause nervous system symptoms, such as dizziness, mental abnormalities, etc. However, this is only a preliminary speculation, and confirmation still needs to use the above detection technology.