Ethyl imidazole-2-carboxylate

Ethyl-imidazole-2-carboxylic acid esters are widely used in various fields of chemistry.
First, in the field of organic synthesis, they are often used as key intermediates. It can interact with many reagents through various reaction pathways to build complex organic molecular structures. For example, in the construction of nitrogen-containing heterocyclic compounds, they can be esterified, cyclized, and substituted by virtue of the activity of imidazole rings and the reactivity of ester groups. A series of compounds with special structures and properties can be derived, which is of great significance for the research and development of new drugs and functional materials.
Second, in the field of pharmaceutical chemistry, it has potential biological activity. Due to its unique molecular structure, it may be compatible with specific targets in vivo, exhibiting biological activities such as antibacterial, anti-inflammatory, and anti-tumor. Scientists can modify and optimize its structure to enhance its activity and reduce toxicity, and then develop new drugs.
Third, it also has applications in materials science. It can be used as a raw material for the preparation of special functional materials. Introduce it into polymer materials through appropriate polymerization reactions or modification methods, endow the materials with unique properties such as special adsorption and conductivity, and have application potential in sensors, separation materials and other fields.
Furthermore, in the field of catalysis, it may play a certain role. Some groups in its structure can be used as ligands to complex with metal ions to form catalysts, which play a catalytic role in specific organic reactions and improve reaction efficiency and selectivity.
In summary, ethyl-imidazole-2-carboxylic acid esters are important chemical substances in many fields such as organic synthesis, drug development, material preparation and catalysis, with broad application prospects and research value.

The synthesis method of Ethyl imidazole-2-carboxylate (2-imidazole ethyl carboxylate) is an important topic in the field of organic synthesis. The synthesis paths are diverse, and in general, there are the following.
First, imidazole is used as the starting material, carboxylate is introduced through carboxylation reaction, and then esterified with ethanol to obtain the target product. In this path, the carboxylation step is quite critical. Commonly used reagents such as carbon dioxide, in the presence of an appropriate base and catalyst, undergo nucleophilic addition with imidazole to form a carboxylated intermediate, and then esterification with ethanol under the action of an acidic catalyst. This process requires precise control of reaction conditions, such as temperature, pH, reaction time, etc., in order to improve yield and purity. < Br >
Second, the imidazole ring structure can be constructed first. With the raw material containing suitable substituents, the imidazole derivative is formed by cyclization reaction, and then it is carboxylated and esterified. For example, using a dicarbonyl compound and ethylenediamine as the starting material, the imidazole ring is formed by condensation cyclization. The subsequent steps are similar to the former. Ethyl imidazole-2-carboxylate is obtained by introducing a carboxyl group and esterification. This method requires careful consideration of the selection of starting materials and cyclization reaction conditions to ensure the selectivity and purity of the cyclization product.
Third, the coupling reaction catalyzed by transition metals. Using halogenated imidazole derivatives and reagents containing carboxyl ethyl ester fragments as raw materials, under the action of transition metal catalysts (such as palladium catalysts), carbon-carbon or carbon-heteroatomic bonds are coupled to obtain the target compound. Although the reaction conditions of such methods are relatively mild, the choice and dosage of catalysts, the design of ligands and other factors have a great impact on the success or failure of the reaction and the yield of the product.
All synthesis methods have their own advantages and disadvantages. According to actual needs, such as raw material availability, cost, product purity and other factors, comprehensive weighing and careful selection are required to achieve the best synthesis effect.

Ethyl-imidazole-2-carboxylic acid ester is a kind of organic compound. Its physical properties are quite unique, let me tell them one by one.
Looking at its appearance, under normal temperature and pressure, it is mostly colorless to light yellow liquid, clear and translucent, like a clear spring, refracting a different luster under light. The smell of this substance is light but not strong, with a little special fragrance, but it is not pungent and intolerable, which is acceptable.
When it comes to melting point and boiling point, the melting point is usually low, and it is not easy to solidify at common ambient temperatures, and it can still maintain the agility of the liquid state. The boiling point is relatively high, and a considerable amount of heat is required to convert it from liquid state to gas state. This property allows it to play a unique role in specific chemical reactions and industrial processes.
Furthermore, its solubility is also worthy of investigation. Ethyl-imidazole-2-carboxylate is soluble in many organic solvents, such as ethanol, acetone, etc., just like fish entering water, it can blend with it. However, its solubility in water is relatively limited, only slightly soluble, due to the difference between the molecular structure of the compound and the polarity of water.
In addition, density is also one of its important physical properties. Its density is slightly higher than that of water. When mixed with water, it is like a stone sinking to the bottom and will settle in the lower layer. This property can be used in the process of separation and purification of substances to help researchers achieve the desired pure product.
In short, the unique physical properties of ethyl-imidazole-2-carboxylic acid esters have laid a solid foundation for their applications in chemistry, materials science and many other fields.

Ethyl imidazole-2-carboxylate (ethyl 2-imidazole carboxylate) is also an organic compound. It has many unique chemical properties.
Looking at its structure, it contains an imidazole ring and an ethyl ester group, which give it specific reactivity. The imidazole ring has electron-rich properties, which enable it to participate in a variety of electrophilic substitution reactions. In case of electrophilic reagents, nitrogen atoms or carbon atoms on the ring can interact with it to form new substitution products.
Ethyl ester groups also have important reactivity. Under basic conditions, a hydrolysis reaction can occur to form 2-imidazole carboxylate and ethanol. This hydrolysis reaction may be controlled and used to prepare 2-imidazole carboxylic acid. And under acidic catalysis, it can also undergo transesterification reaction with alcohols to obtain different ester derivatives, which is a way to synthesize specific esterides.
And because of its nitrogen-containing heterocyclic structure, it can complex with metal ions to form coordination compounds. This property has great potential in the field of catalysis or materials science, and can expand its application range by leveraging the characteristics of metal ions.
In addition, 2-imidazole ethyl carboxylate can form new structures by rearranging atoms in molecules under heating or specific conditions, providing new ideas and products for organic synthesis. In short, its chemical properties are rich and diverse, and it is of great significance in organic synthesis, medicinal chemistry and other fields.

It is difficult to determine the price range of ethyl imidazole-2-carboxylic acid ester in the market. The price often changes due to many factors, such as the quality, the situation of supply and demand, the difficulty of preparation, the competition in the market, and even the different origins and seasons.
In the past, if the quality of high-quality and well-prepared ethyl imidazole-2-carboxylic acid ester was in a market with a shortage of supply and strong demand, the price might be high; however, if the market competition was fierce and the supply was abundant, the price might be lower. And in different places, the price also varies due to logistics costs and tax policies. < Br >
Generally speaking, the price may range from a few yuan to tens of yuan per gram, but this is only a rough estimate. To know the exact price, when you consult the chemical raw material suppliers in detail, and compare the prices in different seasons and channels, you can get a more accurate price range.