Ethyl-4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Ethyl - 4 - (1 - hydroxy - 1 - methylethyl) - 2 - propyl - imidazole - 5 - carboxylate, this is the name of an organic compound. According to the principle of organic chemistry, its chemical structure can be deduced as follows:
The core of this compound is an imidazole ring, which is a five-membered heterocycle containing two nitrogen atoms. At the second position of the imidazole ring, there is a propyl group connected, and the propyl group is a linear alkyl group containing three carbon atoms. At the 5th position of the imidazole ring, there is a carboxylic acid ethyl ester group, that is, the -COOCH 2O CH
structure, in which the carbonyl group is connected to the imidazole ring, and the oxygen atom is connected to the ethyl group. At the 4th position of the imidazole ring, there is a 1-hydroxy-1-methylethyl group, which is formed by removing one hydrogen atom from the isopropanol group, that is, the -C (CH) (OH) CH
structure, in which the hydroxyl group and a methyl group are connected to the same carbon atom, which is then connected to the imidazole ring.
In this way, the chemical structure of this compound is derived from the information conveyed by its naming according to the naming convention of

Ethyl - 4 - (1 - hydroxy - 1 - methylethyl) - 2 - propyl - imidazole - 5 - carboxylate is an organic compound, and its physical properties are quite important, which is related to many practical applications of this compound.
Looking at its appearance, it is often white to off-white crystalline powder, which is conducive to its uniform dispersion and participation in many chemical reactions and preparations. Its melting point is in a specific range, about [X] ° C. The exact value of the melting point can be used as an important indicator to identify the purity of the compound. The higher the purity, the closer the melting point is to the theoretical value, and the narrower the melting range.
When it comes to solubility, this compound exhibits good solubility in organic solvents such as ethanol and acetone. Ethanol, as a common organic solvent, has both hydrophilic hydroxyl and lipophilic ethyl groups in its molecules. It can interact with Ethyl-4- (1-hydroxy-1-methylethyl) -2-propyl-imidazole-5-carboxylate molecules through hydrogen bonds, van der Waals forces, etc., so it can effectively dissolve. However, the solubility in water is poor, because the hydrophobic part of the molecular structure accounts for a large proportion, and the interaction force with water molecules is weak. < Br >
Its density is about [X] g/cm ³, which is of great significance in chemical production, storage and transportation, and helps to determine the appropriate container specifications and material transportation methods. In addition, the compound has certain stability, and can maintain its own chemical structure and properties relatively stable under normal temperature and pressure, dark and dry environments. However, in case of extreme conditions such as strong acid, strong alkali or high temperature, chemical reactions may occur, resulting in structural changes. The physical properties of Ethyl-4- (1-hydroxy-1-methylethyl) - 2-propyl-imidazole-5-carboxylate, such as appearance, melting point, solubility, density and stability, have a profound impact on its applications in chemical and pharmaceutical fields. These properties need to be fully considered in relevant research and production practices.

Ethyl - 4 - (1 - hydroxy - 1 - methylethyl) - 2 - propyl - imidazole - 5 - carboxylate, this is an organic compound. Its common uses are related to many fields.
In the field of pharmaceutical research and development, this compound may have unique pharmacological activities. Or it can act as a lead compound, paving the way for the creation of new drugs. The imidazole structure in the body often plays a key role in drug molecules and can interact with specific targets in organisms, such as enzymes and receptors. For example, a specific enzyme related to a certain type of disease can be precisely combined to inhibit the activity of the enzyme through its unique chemical structure, so as to achieve the purpose of treating diseases.
In the field of materials science, or can participate in the preparation of special materials. Its structural properties or endow the material with different properties, such as improving the stability and solubility of the material. For example, in the synthesis of some polymer materials, the introduction of this compound may optimize the mechanical properties and processing properties of the material, making the material more suitable for specific application scenarios.
In the field of organic synthesis, it is an important intermediate. Chemists can modify and modify their structures through various chemical reactions to derive a series of compounds with different structures, expand the types and functions of organic compounds, and contribute to the development of organic synthetic chemistry.
This compound has important uses in medicine, materials, organic synthesis and other fields, providing key support for scientific research and industrial production.

Ethyl - 4 - (1 - hydroxy - 1 - methylethyl) -2 - propyl - imidazole - 5 - carboxylate, that is, 4- (1 - hydroxy - 1 - methylethyl) -2 - propyl imidazole - 5 - carboxylate ethyl ester, the synthesis method is as follows:
The starting material can be selected from a suitable nitrogen-containing compound and a carbonyl-containing compound, which is achieved by the traditional organic synthesis path, or by multi-step reaction.
The first step can be the reaction of nitrogen-containing heterocyclic compounds with halogenated hydrocarbons in an alkaline environment. If a suitable imidazole derivative is selected, with a halogenated hydrocarbon containing propyl group, such as bromopropane, in the presence of a basic reagent such as potassium carbonate, in a suitable organic solvent such as acetonitrile, heat and stir, undergo a nucleophilic substitution reaction, and introduce propyl at the 2-position of the imidazole ring. This reaction requires precise control of the reaction temperature and time to prevent side reactions from occurring.
Second step, to introduce 1-hydroxy-1-methylethyl at the 4-position, it can be reacted by Grignard reagent. With a suitable halogen, the Grignard reagent is prepared from magnesium chips, and then reacted with the corresponding carbonyl compound to introduce the target group. After the reaction is completed, the product containing hydroxyl groups can be obtained by acidic hydrolysis.
In the last step, a carboxylic acid ethyl ester group is introduced at the 5-position. The compound containing the active group can be reacted with ethanol under the action of a catalyst. If the carboxyl group or its active derivative is prepared first, it is heated and refluxed with ethanol in the presence of a catalyst such as concentrated sulfuric acid, and the esterification reaction is carried out to obtain Ethyl - 4 - (1 - hydroxy - 1 - methylethyl) -2 - propyl - imidazole - 5 - carboxylate. In the
reaction process, the product needs to be separated and purified at each step, and common methods such as column chromatography and recrystallization are used to ensure the purity of the product and achieve the purpose of synthesis.

Ethyl-4- (1-hydroxy-1-methylethyl) - 2-propyl-imidazole-5-carboxylic acid ester, in the use of this product, many matters must be paid attention to.
First of all, regarding its physical and chemical properties, it is necessary to know in detail. The properties, melting point, boiling point, solubility, etc. of this product are all key. Knowing its solubility, in order to prepare the solution, choose the appropriate solvent, so that it can be evenly dispersed and exert the best effect. If its melting point and boiling point are unknown, during heating or cooling operation, it may cause mistakes and damage its structure and properties.
Secondly, safety protection must not be ignored. This material is unknown, or it is toxic, corrosive, or flammable or explosive. When operating, be sure to wear appropriate protective equipment, such as laboratory clothes, gloves, goggles, etc. Work in a well-ventilated place to prevent the accumulation of harmful gases and endanger human health.
Furthermore, storage conditions must also be cautious. A suitable storage environment should be selected according to its chemical properties. Avoid direct sunlight, high temperature and humidity to prevent deterioration. Different chemical substances, or dangerous due to interaction, should be stored in the same place with incompatible objects.
In addition, the method of use should also be accurate. According to the experimental purpose or production requirements, strictly follow the established operating procedures, control the dosage, reaction time, reaction temperature and other parameters. A slight deviation may cause reaction failure, or produce unexpected products, or even lead to safety accidents.
In short, the use of ethyl-4- (1-hydroxy-1-methylethyl) -2-propyl-imidazole-5-carboxylic acid esters should be carefully considered to ensure the safety and effectiveness of the use process.