ethyl 1H-imidazole-2-carboxylate

Ethyl 1H-imidazole-2-carboxylate, which is 1H-imidazole-2-carboxylate, has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the synthesis of many drugs. Because imidazole ring has unique chemical activity and biological activity, it can be used as a basis for various chemical reactions to construct complex drug molecules to achieve specific pharmacological effects. For example, it often plays an important role in the development of antibacterial, antiviral, and antitumor drugs.
In the field of organic synthesis, it is also a kind of widely used building block. By reacting with different reagents, various functional groups can be introduced, expanding the complexity and diversity of molecular structures, and assisting in the synthesis of organic materials with specific properties.
In the field of materials science, materials synthesized from this raw material may have special electrical, optical or mechanical properties, and can be applied to sensors, luminescent materials, etc.
In addition, in some catalytic reaction systems, ethyl 1H-imidazole-2-carboxylate may be used as a ligand or additive to affect the activity and selectivity of catalysts, thereby promoting efficient and highly selective reactions. In short, it has important applications in many scientific and industrial fields, providing a key chemical basis for many research and production processes.

Ethyl 1H-imidazole-2-carboxylate, Chinese name ethyl 1H-imidazole-2-carboxylate, this is an organic compound with unique physical properties.
Looking at its properties, it is mostly colorless to light yellow liquid at room temperature, with a special odor. Because its molecular structure contains specific functional groups, it has a certain chemical activity.
When it comes to melting point, ethyl 1H-imidazole-2-carboxylate has a relatively low melting point and is in a certain temperature range. This property is closely related to its intermolecular forces. Weak intermolecular forces cause the lattice structure to be destroyed at relatively low temperatures and change from solid to liquid.
In terms of boiling point, its boiling point is in a certain range, which is the temperature required to convert a liquid into a gas under a specific pressure. The boiling point is affected by factors such as intermolecular interactions and molecular mass, and the molecular structure and composition of ethyl 1H-imidazole-2-carboxylate determine its boiling point.
In terms of solubility, ethyl 1H-imidazole-2-carboxylate has a certain solubility in organic solvents such as ethanol and ether. Due to the similar principle of compatibility, its molecules can form specific interactions with organic solvent molecules to promote dissolution. However, the solubility in water is relatively small, because its molecular polarity does not match exactly with water.
Density is also an important physical property. The density of ethyl 1H-imidazole-2-carboxylate is in a certain numerical range, which is different from the density of water and other common organic solvents. This property has important applications in separation, purification and related chemical processes.
In summary, the physical properties of ethyl 1H-imidazole-2-carboxylate are determined by its molecular structure, which has far-reaching impact on its applications in organic synthesis, medicinal chemistry and other fields.

The method of preparing ethyl ethyl ethyl ethyl ethyl carboxylate ethyl-1H-imidazole-2-carboxylic acid has several paths.
First, imidazole-2-carboxylic acid is used as the starting material, and it is esterified with ethanol in the presence of an acid catalyst. Among them, sulfuric acid, p-toluenesulfonic acid, etc. are commonly used as catalysts. At the appropriate temperature and reaction time, the carboxylic acid and alcohol work to produce the target product and water. This process requires attention to the control of the reaction conditions, such as the temperature should not be too high to prevent side reactions from happening, and the water can be removed by a water separator, so that the reaction moves in the direction of generating esters.
Second, imidazole can be reacted with ethoxy Imidazole has an active nitrogen atom and can undergo nucleophilic substitution with the acyl chloride group of ethoxy formyl chloride. First dissolve imidazole in a suitable solvent, such as dichloromethane, N, N-dimethylformamide, etc., and add ethoxy formyl chloride dropwise at low temperature. During the reaction, the temperature and dropwise rate should be controlled to avoid side reactions. After the reaction is completed, pure ethyl-1H-imidazole-2-carboxylate is obtained through post-treatment steps such as neutralization, extraction, drying, and distillation.
Third, it can also react with bases such as ethanol and potassium carbonate from 2-halo imidazole in a suitable solvent. The halogen atom of 2-halomidazole has high activity. Under the action of alkali, the ethoxyl group of ethanol attacks the halomidazole and replaces the halogen atom to form ethyl-1H-imidazole-2-carboxylate. In this path, the solvent is very important, such as acetone, acetonitrile, etc., and the amount of base and the reaction temperature need to be controlled to optimize the reaction effect.

Ethyl-1H-imidazole-2-carboxylic acid esters are chemical substances, and many aspects need to be paid attention to when storing.
First, when stored in a cool place. This is because the substance may be sensitive to temperature, high temperature can easily cause its properties to change. If the temperature is too high, it may cause a chemical reaction and cause it to deteriorate, which will affect subsequent use.
Second, be sure to keep a dry environment. Moisture can easily make the substance damp, or react such as hydrolysis, resulting in chemical structure changes and quality damage. Like in humid places in the south, more attention should be paid to moisture prevention, and desiccants can be used to maintain a dry storage environment.
Third, the storage place needs to be well ventilated. If the ventilation is poor, once the substance evaporates, accumulates to a certain concentration, or causes safety hazards, such as the formation of explosive mixed gases, it may explode in case of open flames and other incentives.
Fourth, keep away from fire sources and oxidants. Ethyl-1H-imidazole-2-carboxylate may be flammable, and it is easy to cause combustion when the fire source is close to it; and oxidant contact with it, or trigger a violent oxidation reaction, is also dangerous.
Fifth, it should be stored in a suitable container. Choose a container that is compatible with it to prevent the material of the container from reacting with the substance. For example, do not use a material container that will be corroded, so as not to damage the container and cause material leakage.
In addition, the storage area should also be clearly labeled, indicating the name of the substance, its characteristics, and dangerous precautions, etc., so that personnel can identify and operate it, ensure storage safety, and avoid deterioration of the substance due to misoperation or improper storage or cause safety accidents.

I don't know the market price of ethyl + 1H - imidazole - 2 - carboxylate (ethyl - 1H - imidazole - 2 - carboxylate). At the time of "Tiangong Kaiwu", there was no relevant transaction for this product, so it is difficult to answer according to its words. However, if you want to know the current market price of this product, you should look for it in the chemical raw material trading market and chemical reagent suppliers. You can inquire about major chemical product sales platforms, or call professional chemical reagent dealers to inquire about its price. Due to market supply and demand, product purity, brand differences and many other factors, its price fluctuates. Or the price is high due to improved purity, scarcity of raw materials, or the price is low due to increased production capacity and intense competition. It is necessary to carefully monitor market dynamics and compare them with multiple parties in order to obtain a relatively accurate price.