What are the main uses of Climbazole?

Climbazole, a chemical substance, often known as glycopene, is widely used in various industries. Its main users are two, one is medicine, and the other is daily chemical.

In the pharmaceutical industry, climbazole is a good medicine for treating skin fungal diseases with its significant anti-fungal ability. Fungi are prone to skin tinea, dandruff and other diseases, and climbazole can inhibit the growth and reproduction of fungi and protect the skin from health. For example, in various anti-fungal ointments and lotions, this substance is often added, which can effectively remove the itching, redness and swelling of skin tinea, and also moisturize the skin.

In the daily chemical industry, climbazole is especially commonly used in shampoo and hair care products. The birth of dandruff is mostly due to the excessive growth of Malassezia on the scalp. Climbazole can precisely suppress this bacteria, reduce the abnormal proliferation of scalp keratinocytes, and effectively remove dandruff. Many anti-dandruff shampoos in the market today contain climbazole, which can help users get refreshing and dandruff-free hair.

And because of its stable chemical properties, it can be integrated with other ingredients to increase its stability and shelf life in the product. Therefore, climbazole plays an important role in the pharmaceutical and daily chemical industries, making great contributions to the improvement of human health and quality of life.

Climbazole is commonly found in which products

Climbazole is the name of a chemical substance, often called clotrimazole in Chinese. Among many products, this substance is quite common.

Looking at many shampoo and hair care products, it often contains Climbazole. Because of its antifungal effect, it can effectively deal with dandruff itching caused by the growth of fungi on the scalp. Therefore, many anti-dandruff shampoos often use Climbazole as an important ingredient for the purpose of anti-dandruff and anti-itching. Its ratio in the shampoo often varies according to the product design and efficacy, and it is precisely regulated to achieve the best anti-dandruff effect.

In addition, Climbazole can also be seen in some external skin care ointments or lotions. The antifungal properties of Climbazole can help drugs effectively fight fungi and promote the recovery of skin diseases due to the occasional fungal diseases of the skin, such as tinea corporis and tinea cruris. In the pharmaceutical process, according to the needs of the disease and drug formula, the content of Climbazole is rationally prepared to bring good curative effects to patients.

There are also oral care products. Some specific mouthwashes or oral gels may also contain Climbazole. In the mouth, if there is any discomfort caused by fungi, such as thrush, Climbazole can exert its antifungal effect and maintain a healthy environment in the mouth. In the development of these oral care products, considering the special environment and use needs of the mouth, an appropriate amount of Climbazole is added to achieve the effect of cleaning the mouth and inhibiting fungi.

How safe is the Climbazole?

In terms of toxicology studies, it has been verified by many experiments that the appropriate amount of climbazole is generally low in human toxicity. Acute toxicity tests show that even if given a higher dose, it does not cause severe acute poisoning symptoms.

In terms of skin contact, products containing this ingredient are normally used, and most people have good skin tolerance. Only a very small number of people may experience mild allergic reactions, such as skin redness, itching, etc., due to individual differences, but such situations are rare.

When in contact with the eye, if it is not carefully entered into the eye, it may cause temporary irritation, but after rinsing with water, it usually relieves quickly and rarely causes lasting damage.

In terms of environmental safety, climbazole has certain degradability in the natural environment. Although studies have focused on its residues in water and other environments, current evidence shows that its long-term negative effects in the environment are relatively limited.

Overall, under the premise of following normal use norms, climbazole has considerable safety and can be used by the public with confidence in related personal care products to achieve anti-dandruff and other effects without excessive concerns about its safety.

What is the production process of Climbazole?

Climbazole, whose alias is 1- (4-chlorobenzyl) -1H-imidazole-5-ol, is a commonly used anti-dandruff agent. The process of its fabrication has been studied, as described below.

The first amount of 4-chlorobenzyl chloride is taken and placed in the reactor. Add a solution of 4-chlorobenzyl chloride, such as toluene, to make the dissolution uniform. Another solution of imidazole is added dropwise into the reactor. This step requires control of the degree of resistance, so that it can be maintained at about 20-30 ° C. Due to the activity of imidazole, the degree of resistance is high and the reaction is strong, and it can be controlled; the degree of resistance is low and the reaction is slow, and it only increases for a few days.

After the dropwise addition is completed, it is necessary to reverse the mixing. Chen. In this step, 4-chlorobenzyl chloride imidazole can be biochemically reacted to form the medium compound 1- (4-chlorobenzyl) imidazole. The medium compound still needs to be purified in one step.

The medium compound is placed in another reactive container, and the amount of oxidation, such as oxidation or high acid, is added to make it oxidize. This step also needs to be controlled. The reaction temperature is between 50 and 60 degrees Celsius, and the reaction temperature is between 50 and 60 degrees Celsius, so that 1- (4-chlorobenzyl) imidazole can be reacted to 1- (4-chlorobenzyl) -1H-imidazole-5-ol, that is, climbazole.

After the reaction is completed, the process needs to be completed in 10 minutes. First, it is extracted by the solution of the product, and the product is extracted from the reverse solution of the climbazole. Then, by steaming, the dissolved product is removed to obtain the crude climbazole. Then, by the method of heavy crystallization, the appropriate solution is used, such as ethanol, acetone, etc., to re-crystallize many times to improve the quality of the product, and the highest degree of climbazole can be obtained.

What is the difference between Climbazole and other similar ingredients?

Climbazole is a special anti-dandruff agent. Its chemical name is 1- (4-chlorobenzyl) -1H-imidazole-5-ol, which is common in shampoo and hair care products. Compared with other similar ingredients, the differences are quite obvious, as detailed below.

First discussion on the structure. Climbazole has a unique chemical structure, with an imidazole ring as the core, connected with chlorobenzyl and hydroxyl groups. This structure gives it specific chemical activity and stability. Compared with similar products, such as ZPT (zinc pyrithione), ZPT is formed by the coordination of pyridine ring and zinc thione, and has a very different structure. The different structures cause the physical and chemical properties of the two to be different, such as solubility and stability. Climbazole has good solubility in organic solvents, while ZPT has limited solubility in water.

Next talk about efficacy. Climbazole has excellent anti-dandruff effect and can effectively inhibit the growth of Malassezia, which is the main cause of dandruff. Its mechanism of action is to interfere with the synthesis and metabolism of Malassezia cell membranes. Although other ingredients can also inhibit this bacterium, there are different ways. Such as OCT (Gumbazole), it works by inhibiting the synthesis of fungal ergosterol. In terms of efficacy, Climbazole has a fast and long-lasting effect, and long-term use can significantly reduce dandruff generation and improve the scalp environment. Some plant extracts, although naturally mild, have a slightly slower effect and take a long time to show effect.

Furthermore, safety. Climbazole is widely recognized for its safety. Toxicological studies have shown that it has low toxicity to humans and is less irritating to the skin. However, it still needs to be used according to the standard dosage. In comparison, some traditional anti-dandruff ingredients, such as coal tar, although strong anti-dandruff, have potential carcinogenic risks and are not safe. Therefore, Climbazole has the advantage in safety and is more suitable for daily hair care products.

To sum up, Climbazole has obvious differences from other similar ingredients in terms of structure, efficacy and safety. With its unique advantages, it occupies an important place in the field of anti-dandruff agents.