Acide 2-(4-pyridinyl)-1H-benzimidazole-4-carboxylique

2- (4-pyridyl) -1H-indole-4-carboxylic acid, this compound has a wide range of uses in medicine, materials and other fields. In medicine, as a key intermediate, it plays an important role in the process of creating new drugs. The structure of Gainpyridyl and indole ring endows the compound with unique physiological activities and pharmacological properties.
Numerous studies have focused on the development of innovative drugs with high activity, high selectivity and low toxicity and side effects by modifying the structure of 2- (4-pyridyl) -1H-indole-4-carboxylic acid. For example, in the field of anti-tumor drug development, scientists hope that by fine-tuning its structure, the compound can precisely act on specific targets of tumor cells, inhibit tumor cell proliferation and induce apoptosis, while minimizing damage to normal cells and improving therapeutic effects.
In the field of materials, 2- (4-pyridyl) -1H-indole-4-carboxylic acids can be used to prepare functional materials. Due to its special molecular structure and electronic properties, it can participate in the design and synthesis of materials, giving materials special optical, electrical or magnetic properties. For example, in the field of organic photovoltaic materials, it can be introduced into conjugated systems to optimize the photoelectric conversion efficiency and stability of materials, providing new opportunities for the development of photovoltaic devices such as solar cells and Light Emitting Diodes.
In summary, 2- (4-pyridyl) -1H-indole-4-carboxylic acids have shown broad application prospects in the fields of medicine and materials due to their unique structures and properties. With the continuous deepening of research, it is expected to bring more breakthroughs and innovations in related fields.

The synthesis method of 2- (4-pyridyl) -1H-indole-4-carboxylic acid, although the book "Tiangong Kaiwu" does not directly describe the synthesis of this specific compound, it contains scientific thinking and process concepts, or it can be inspired by ideas.
To form this product, you can start with the selection of raw materials and the planning of the reaction path. First, take a suitable compound containing pyridyl and indole structures as the starting material, or find a natural product with this part of the structure. After ingenious chemical modification, the pyridyl group and indole are properly connected.
In the reaction path, or the nucleophilic substitution reaction can be used to combine the activity check point of the pyridyl group with the specific position of the indole. For example, the halogenated pyridine and indole derivatives are selected. In the presence of a suitable base and catalyst, the halogen atom is replaced by the indole active site to form a 2- (4-pyridyl) -1H-indole basic structure.
After the basic structure is obtained, the carboxylic acid functional group is introduced. Or by oxidation reaction, the suitable substituent is oxidized to a carboxyl group. For example, the structure contains oxidizable side chains, such as methyl, with a strong oxidizing agent, at a suitable temperature, reaction time and solvent environment, it is converted to a carboxyl group to obtain 2- (4-pyridyl) -1H-indole-4-carboxylic acid. The whole process of
synthesis requires precise temperature control and time control, and suitable solvents and catalysts are selected to ensure the efficient and high selectivity of the reaction. After each step of the reaction is completed, the product should be purified by suitable separation and purification methods, such as column chromatography, recrystallization, etc., to remove impurities to achieve the high purity requirements of the target product. In this way, the synthesis of 2- (4-pyridyl) -1H-indole-4-carboxylic acid can be achieved according to reasonable design and experimental operation.

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2-%284-%E5%90%A1%E5%95%B6%E5%9F%BA%29-1H-%E8%8B%AF%E5%B9%B6%E5%92%AA%E5%94%91-4-%E7%BE%A7%E9%85%B8%E7%9A%84%E5%85%B7%E4%BD%93%E5%8C%96%E5%AD%A6%E5%BC%8F%E4%B8%BA $C_ {14} H_ {11} NO_ {4} $. This substance is an organic compound with the following physical and chemical properties:
- ** Properties **: Under normal temperature and pressure, it is often in a solid state, but the specific appearance may vary depending on the purity and crystallization conditions, or it is white to light yellow powder, or it is crystalline.
- ** Melting point and boiling point **: The melting point is about [X] ° C, at this temperature, the substance changes from solid to liquid; the boiling point is affected by environmental pressure, and at normal pressure, the boiling point is about [X] ° C, when it changes from liquid to gas. < Br > - ** Solubility **: In common organic solvents, such as ethanol and acetone, there is a certain solubility, which can form a uniform solution. However, the solubility in water is relatively small, due to the ratio of polar groups to non-polar groups in the molecular structure, which makes the substance poorly hydrophilic.
- ** Stability **: Under normal environmental conditions, it has certain chemical stability. However, when exposed to strong oxidizing agents, strong acids, and strong bases, some functional groups in the molecule may be oxidized; when exposed to strong acids or bases, ester groups and other functional groups may undergo hydrolysis reactions. < Br > - ** Acid and basic **: The molecule contains acidic groups such as carboxyl groups, so it has a certain acidity, which can neutralize with bases to generate corresponding salts and water.
- ** Spectral properties **: In infrared spectroscopy, specific functional groups will produce absorption peaks at the corresponding wavenumber, such as carboxyl groups at 1700-1750 $cm ^ {-1} $with strong absorption peaks, which can help identify molecular structures; in nuclear magnetic resonance hydrogen spectroscopy, hydrogen atoms in different chemical environments will peak at different chemical shifts, providing a basis for determining the number of hydrogen atoms and the connection mode.

2-%284-%E5%90%A1%E5%95%B6%E5%9F%BA%29-1H-%E8%8B%AF%E5%B9%B6%E5%92%AA%E5%94%91-4-%E7%BE%A7%E9%85%B8%EF%BC%8C%E5%85%B6%E5%90%8D%E5%8F%82%E8%80%83%E4%B8%BA2- (4-pyridyl) -1H-indole-4-carboxylic acid. This compound has important applications in pharmaceutical research and development, materials science, organic synthesis and many other fields.
In the field of pharmaceutical research and development, due to its unique chemical structure and activity, it has attracted much attention in the development of anti-tumor drugs. Studies have shown that these compounds can act on specific targets of tumor cells, inhibit tumor cell proliferation and induce apoptosis. For example, some derivatives with its core structure have been experimentally verified to show good inhibitory activity on some cancer cell lines, and are expected to be developed into new anti-tumor drugs. At the same time, in the research and development of drugs for neurological diseases, it may regulate neurotransmitter transmission, protect nerve cells, and bring new opportunities for the treatment of neurological diseases such as Parkinson's disease and Alzheimer's disease.
In the field of materials science, 2- (4-pyridyl) -1H-indole-4-carboxylic acid can be used as a key structural unit to construct functional materials. Using its coordination ability with metal ions, metal-organic framework materials (MOFs) with special optical, electrical and magnetic properties can be prepared. Such MOFs materials exhibit excellent properties in gas adsorption and separation, fluorescence sensing, catalysis, etc. For example, some MOFs based on this compound have high selective adsorption capacity for specific gases, which can be used for environmental gas purification and separation.
In the field of organic synthesis, this compound, as an important intermediate in organic synthesis, can construct organic molecules with more complex structures through a variety of chemical reactions. Various substitution reactions and coupling reactions can be carried out on its pyridyl and indole rings, providing an effective way for the synthesis of organic compounds with specific functions and structures. Chemists can use this to design and synthesize new compounds with different biological activities and material properties, promoting the development of organic synthesis chemistry.