6 Methyl 1h Benzimidazole
quinoline thiophene imidazole thiazole

6-methyl-1H-benzimidazole

    Specifications

    HS Code

    739375

    Name 6-methyl-1H-benzimidazole
    Molecular Formula C8H8N2
    Molar Mass 132.16 g/mol
    Appearance Solid (usually white to off - white powder)
    Odor Odorless (usually)
    Melting Point 200 - 203 °C
    Solubility In Water Poorly soluble
    Solubility In Organic Solvents Soluble in some organic solvents like ethanol, DMSO
    Pka Approximately 1.75 (for the conjugate acid)
    Crystal Structure Typically forms orthorhombic or monoclinic crystals

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    Frequently Asked Questions

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    What is the chemical structure of 6-methyl-1H-benzimidazole?
    6 - methyl - 1H - benzimidazole, the chemical is interesting. Among them, it contains a benzimidazole parent nucleus. This parent nucleus is fused with benzimidazole, just like the jade of the magic, ingenious. Benzene is the fragrance of six elements, with a special fragrance, just like a quaint flower, with the charm of setting. Imidazole is a five-element nitrogen-containing compound, with a nitrogen atom residing in a specific position, such as in the fine, and it has a special property.
    And 6-methyl is in the sixth position of the benzimidazole parent nucleus, with a methyl group. This methyl group is like a delicate compound, added to the parent nucleus. A methyl group is composed of three atoms of one carbon atom, which can affect the physical properties of the whole molecule. Its existence or modification of the properties of the molecule, or the action of the molecule, is like adding a subtle color to a beautiful ancient painting, making the whole taste different.
    Of course, the synthesis of 6-methyl-1H-benzimidazole is made from the methyl group of the 6-position benzimidazole parent nucleus, and the parts work together with each other, giving this compound its unique properties, just like the ancient craftsman's carefully carved materials, which are wonderful.
    What are the main uses of 6-methyl-1H-benzimidazole?
    6-Methyl-1H-benzimidazole has a wide range of uses. In the field of medicine, it is often the key raw material for the creation of drugs. Due to its unique structure, it can be chemically modified to derive a variety of compounds with special pharmacological activities to treat various diseases. For example, some drugs based on this have the effect of inhibiting the proliferation of some tumor cells and are expected to become anti-cancer drugs; some drugs can regulate human physiology and help treat diseases of the nervous system or cardiovascular system.
    In materials science, it has also made a name for itself. It can participate in the synthesis of polymer materials with special properties, giving materials unique electrical, optical or thermal properties. If the luminescent material is made, it can be used for display technology to improve display effect and performance; the conductive polymer made has potential applications in the field of electronic devices, such as the preparation of high-performance battery electrode materials.
    Furthermore, in the agricultural field, 6-methyl-1H-benzimidazole is also used. It can be used as an important intermediate in pesticide synthesis, and can be chemically converted to generate pesticides with bactericidal, insecticidal or herbicidal activities. Such pesticides can effectively control crop diseases and pests, ensure the healthy growth of crops, improve crop yield and quality, and escort agricultural production. From this perspective, 6-methyl-1H-benzimidazole has important uses in many fields such as medicine, materials, and agriculture, and has made great contributions to the development of related industries.
    What are the physical properties of 6-methyl-1H-benzimidazole?
    6-Methyl-1H-benzimidazole is one of the organic compounds. Its physical properties are quite unique, let me tell them one by one.
    Looking at its appearance, it is often a white to light yellow crystalline powder, delicate and uniform, under sunlight, or shimmering, like fine jade chips. This morphological feature makes it recognizable in many substances.
    The melting point is about 210-215 ° C. When the temperature gradually rises, the substance begins to slowly melt from a solid state to a liquid state. During this process, the intermolecular forces change and the lattice structure disintegrates. The exact value of the melting point provides an important reference for its application in chemical, pharmaceutical and other fields.
    Its solubility also has characteristics. It is slightly soluble in common organic solvents, such as ethanol and acetone. In ethanol, after moderate stirring, it is partially soluble, forming a slightly cloudy solution, just like a light mist cage. However, in water, its solubility is very small, only a very small amount can be dispersed, and most of them sink in the bottom of the water, just like sand and gravel do not melt in water. This difference in solubility is crucial in the process of separation, purification and preparation of preparations.
    Furthermore, its stability is quite good. In a normal temperature and pressure, dark and dry environment, it can be stored for a long time without easy deterioration. However, if exposed to strong light, hot topics or contact with strong oxidants, chemical reactions may occur, resulting in structural and property changes.
    The physical properties of 6-methyl-1H-benzimidazole have their own uses, and they are all indispensable factors in chemical synthesis, drug development and many other aspects. Just like in a delicate chess game, each piece is of key significance.
    What are 6-methyl-1H-benzimidazole synthesis methods?
    6-Methyl-1H-benzimidazole is also an organic compound. The synthesis methods are many different, and the common ones are as follows:
    First, o-phenylenediamine and acetic acid are used as raw materials. Co-heating of o-phenylenediamine and acetic acid, the two are obtained by condensation reaction under suitable temperature, pressure and catalyst. 6-methyl-1H-benzimidazole is obtained by condensation reaction. The key to this reaction is the control of temperature. If the temperature is too high, side reactions are prone to occur; if the temperature is too low, the reaction is slow and the yield is not high.
    Second, o-nitrotoluene is used as the starting material. O-nitrotoluene is first oxidized to obtain o-nitrobenzoic acid. Then the o-nitrobenzoic acid is reduced to o-aminobenzoic acid, and then reacted with formamide, and after a series of transformations, the target product can be obtained. There are many steps in this path, but the raw materials are common and the cost is controllable. During the oxidation and reduction process, suitable reagents and conditions need to be selected to ensure the smooth reaction and the purity of the product.
    Third, other benzimidazole derivatives are also used as substrates, and methyl is introduced through methylation reaction to obtain 6-methyl-1H-benzimidazole. This rule requires the selection of suitable methylation reagents, such as iodomethane, dimethyl sulfate, etc., and the selectivity of the reaction should be considered to avoid the introduction of methyl at other positions, resulting in complex and impure products.
    All synthesis methods have their own advantages and disadvantages. In practical application, when considering the availability of raw materials, cost, product purity requirements and other factors, the optimal method is selected to form this compound.
    6-methyl-1H-benzimidazole what are the precautions during use
    6-Methyl-1H-benzimidazole is an important organic compound that has a wide range of uses in many fields. However, when using it, the following things should not be ignored:
    First, keep safety protection in mind. This compound may be toxic and irritating, and can harm the human body if it touches the skin, eyes, or is inhaled or ingested. When using, be sure to wear appropriate protective equipment, such as protective gloves, goggles, masks, etc., to prevent direct contact. In case of accidental contact, rinse with plenty of water immediately, and seek medical treatment or further treatment according to the specific situation.
    Second, storage conditions must be appropriate. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources, and protected from direct sunlight. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., and should not be mixed to avoid dangerous chemical reactions.
    Third, the use environment should be ventilated. Whether it is in a laboratory test or an industrial large-scale use, it is necessary to ensure that the use environment is well ventilated. Good ventilation can discharge volatile vapor in time, reduce the concentration of the compound in the air, reduce the risk of inhalation, and avoid the formation of explosive mixed gases.
    Fourth, strictly abide by the operating procedures. Before use, be sure to familiarize yourself with relevant operating procedures and safety precautions. Every step of weighing, dissolving, and reacting must be accurate, and the reaction conditions, such as temperature, pressure, and reaction time, must be strictly controlled. The established parameters must not be changed without authorization to prevent accidents.
    Fifth, waste disposal should not be sloppy. Waste generated during use, including expired products, reaction residues, etc., must not be discarded at will. It needs to be sorted, collected, and properly disposed of in accordance with relevant regulations and environmental protection requirements to avoid pollution to the environment.
    In short, when using 6-methyl-1H-benzimidazole, safety and environmental protection must be given top priority, and careful operation must not be slack at all to ensure the safety of personnel and the environment is not damaged.