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What is the chemical structure of 6-methoxy-2- {[ (4-methoxy-3, 5-dimethylpyridin-2-yl) methyl] sulfanyl} -1H-benzimidazole?
6-Methoxy-2 - {[ (4-methoxy-3,5-dimethylpyridine-2-yl) methyl] thioalkyl} -1H-benzimidazole, which is an organic compound. Its chemical structure is complex and delicate, composed of several parts cleverly spliced together.
Bear the brunt, looking at its core, it is the structure of benzimidazole. Benzimidazole, which is fused with a benzene ring and an imidazole ring, has a unique aromatic and chemical activity. Its 1H logo indicates that the hydrogen atom is attached to the No. 1 position of the imidazole ring.
At one end of the side chain, there is a 6-methoxy group. This methoxy group, that is, methoxy group, is attached to the 6th position of the benzimidazole benzene ring. The introduction of methoxy groups can change the physical and chemical properties of compounds, such as solubility, electron cloud distribution, etc.
The other side chain is 2 - { (4-methoxy-3,5-dimethylpyridine-2-yl) methyl] thialkyl}. Among them, the thialkyl group uses the sulfur atom as a bridge to connect benzimidazole to another pyridine derivative. In the pyridine derivative part, 4-methoxy is located at the 4th position of the pyridine ring, and 3,5-dimethyl is located at the 3rd and 5th positions. The various parts of this structure interact with each other and co-shape the properties of the compound.
In this way, 6-methoxy-2 - {[ (4-methoxy-3,5-dimethylpyridine-2-yl) methyl] thioalkyl} -1H-benzimidazole has potential applications and research value in organic synthesis, pharmaceutical chemistry and other fields due to its unique chemical structure.
What are the main uses of 6-methoxy-2- {[ (4-methoxy-3, 5-dimethylpyridin-2-yl) methyl] sulfanyl} -1H-benzimidazole?
6-Methoxy-2 - {[ (4-methoxy-3,5-dimethylpyridine-2-yl) methyl] thioalkyl} -1H-benzimidazole, an organic compound, has shown important uses in many fields.
In the field of medicine, it can be used as a drug intermediate. The structure of Geinbenzimidazole is quite common in pharmaceutical chemistry, and many biologically active drugs contain this structural unit. After appropriate modification and transformation, the compound may be able to develop new drugs, such as some therapeutic drugs for specific diseases, or have antibacterial, antiviral, and antitumor effects. Due to the specific chemical structure, it can interact with the target in the organism, thereby regulating the biological process and exerting the therapeutic effect.
In the field of materials science, it may be used to synthesize materials with special properties. The structural diversity of organic compounds endows materials with unique physical and chemical properties. By introducing the compound into the material synthesis process, it may endow materials with special properties such as optics, electricity, heat, etc., and then be applied to optoelectronic materials, sensor materials and other fields. For example, by rational design, or by making the material have sensitive response characteristics to specific substances, it can be used to fabricate high-sensitivity sensors.
In the field of organic synthetic chemistry, it is an important synthetic building block. The purpose of organic synthesis is to construct complex organic molecules. The specific structure and functional group of this compound can be used as a starting material or key intermediate to construct more complex and functional organic compounds through various organic reactions, such as nucleophilic substitution, oxidation reduction, etc., providing rich materials and possibilities for the development of organic synthetic chemistry.
What are the physical properties of 6-methoxy-2- {[ (4-methoxy-3, 5-dimethylpyridin-2-yl) methyl] sulfanyl} -1H-benzimidazole?
6-Methoxy-2 - {[ (4-methoxy-3,5-dimethylpyridine-2-yl) methyl] thialkyl} -1H-benzimidazole, which is an organic compound. Its physical properties are very important, related to its performance in various chemical processes and practical applications.
First, the appearance is often presented as a solid state, mostly white or off-white crystalline powder. This appearance feature is not only easy to identify, but also relatively stable during storage and transportation, and is not easy to volatilize or lose.
Melting point is one of the key physical properties. After experimental determination, its melting point is in a specific temperature range, which is an important indicator of the purity and structural stability of the compound. If the melting point deviation is large, or it suggests that the compound contains impurities, it will affect its quality and performance.
The solubility cannot be ignored. In common organic solvents, such as methanol, ethanol, dichloromethane, etc., it exhibits a certain solubility. However, the solubility in water is poor, which is of great significance in the separation, purification and preparation of compounds. If the compound is extracted, a suitable organic solvent can be selected according to its solubility to achieve the purpose of efficient separation.
Furthermore, the density of the compound is a fixed value. Although in some application scenarios, the effect of density is not as significant as melting point and solubility, in the process of specific chemical production and pharmaceutical preparations, accurate knowledge of density is conducive to material ratio and product quality control.
In addition, its stability is good, and it can maintain the structure and properties for a long time under normal temperature, pressure and general storage conditions. In case of extreme conditions such as high temperature, strong acid and strong alkali, or chemical reactions occur, resulting in structural changes and performance damage.
In summary, the physical properties of 6-methoxy-2- {[ (4-methoxy-3,5-dimethylpyridine-2-yl) methyl] thialkyl} -1H -benzimidazole, such as appearance, melting point, solubility, density and stability, are of critical significance in chemical research, drug development and industrial production, and provide important reference for related operations and applications.
What are the synthesis methods of 6-methoxy-2- {[ (4-methoxy-3, 5-dimethylpyridin-2-yl) methyl] sulfanyl} -1H-benzimidazole?
The synthesis method of 6-methoxy-2- {[ (4-methoxy-3,5-dimethylpyridine-2-yl) methyl] thio} -1H-benzimidazole, although the ancient book "Tiangong Kaiwu" does not contain this substance, but looking at its chemical synthesis, it can be deduced by analogy.
To prepare this substance, one can first take 6-methoxy-1H-benzimidazole as a group, react with appropriate halogenated reagents, and introduce the active group at the 2-position to facilitate the formation of subsequent thioether bonds. Second, another 4-methoxy-3,5-dimethylpyridine-2-based methyl halide is prepared, and the halide is reacted with a sulfur-containing nucleophile to obtain (4-methoxy-3,5-dimethylpyridine-2-yl) methyl mercaptan or its corresponding salt. Third, the above-mentioned sulfur-containing product is reacted with 6-methoxy-2-halo-1H-benzimidazole in a suitable base and solvent environment to promote the formation of thioether bonds, and then obtain the target product.
Or there may be other methods. The benzimidazole ring system can be constructed first, and the methoxy group is introduced at an appropriate stage. At the same time, the pyridine part is modified, and the sulfur-containing side chain is introduced at the pyridine 2-position. After cyclization, 6-methoxy-2-{ [ (4-methoxy-3,5-dimethylpyridine-2-yl) methyl] thio} -1H-benzimidazole is obtained. During the reaction, attention should be paid to the control of reaction conditions, such as temperature, pH, reaction time, etc., which are all related to the yield and purity of the product.
6-Methoxy-2- {[ (4-methoxy-3, 5-dimethylpyridin-2-yl) methyl] sulfanyl} -1H-benzimidazole What are the precautions during use?
6-Methoxy-2 - {[ (4-methoxy-3,5-dimethylpyridine-2-yl) methyl] thio} -1H-benzimidazole is a very important chemical substance. During use, many matters need to be paid attention to.
First, safety is extremely critical. This chemical may be toxic and irritating, and comprehensive protective measures must be taken when coming into contact. During operation, wear suitable protective clothing, gloves and goggles, and beware of contact with skin and eyes. In case of accidental contact, rinse with plenty of water immediately and seek professional medical attention according to the specific situation. At the same time, ensure that the operating environment is well ventilated to prevent inhalation of dust or volatile gases generated by the substance, so as not to cause damage to the respiratory tract.
Second, the storage conditions should not be ignored. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. It should be stored separately from oxidants, acids, alkalis and other substances, and must not be mixed to prevent dangerous chemical reactions. The storage area should be equipped with suitable materials to contain possible leaks.
Third, the use specifications must be strictly followed. Before use, it is necessary to understand its chemical properties and reaction characteristics in detail. According to specific experimental or production needs, the amount of use and reaction conditions should be precisely controlled. During the reaction process, pay close attention to the reaction phenomenon and parameter changes. If there is any abnormality, deal with it properly immediately. After use, dispose of and clean the remaining substances and related appliances in a standardized manner to prevent adverse consequences from the residual substances.
Fourth, caution is also required in the transportation process. During transportation, the substance should be properly packaged and marked in accordance with relevant regulations and standards to ensure transportation safety and prevent dangerous situations such as leakage due to package damage caused by bumps, collisions, etc.