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What is the chemical structure of 6-Methoxy-2- [[ (4-methoxy-3, 5-dimethyl-1-oxido-2-pyridinyl) methyl] sulfinyl] -1H-benzimidazole
This is related to the chemical structure of 6-methoxy-2- [ (4-methoxy-3,5-dimethyl-1-oxidized-2-pyridyl) methyl] sulfinyl] -1H-benzimidazole. According to its name, this compound is cleverly spliced from benzimidazole, pyridine and other parts.
Benzimidazole is its core structure, 1H-benzimidazole, which is a fused form of a five-membered nitrogen heterocycle and a benzene ring. It is common in many drugs and bioactive molecules, with unique electronic properties and biological activity tendencies. The 6-methoxy group is introduced into the 6 position of benzimidazole. The addition of this methoxy group can change the electron cloud distribution and lipophilicity of the molecule, thereby affecting its pharmacological activity.
Looking at the 2- [ (4-methoxy-3,5-dimethyl-1-oxidized-2-pyridyl) methyl] sulfinyl] part again, the pyridine ring is also an important heterocyclic structure, 4-methoxy-3,5-dimethyl-1-oxidized-2-pyridyl shows that the pyridine ring has methoxy at position 4, dimethyl at positions 3 and 5, and the pyridine nitrogen atom is oxidized. This pyridine structure is connected to the sulfinyl group through methylene, and then to the second position of benzimidazole. Sulfinyl - S (= O) - is a double bond between the sulfur atom and the oxygen atom, giving the molecule a specific polarity and reactivity.
Such a complex and delicate structure, the parts cooperate with each other, or the compound has unique physical, chemical and biological activities, which may have great potential in the field of drug development and other fields.
What are the main uses of 6-Methoxy-2- [ (4-methoxy-3, 5-dimethyl-1-oxido-2-pyridinyl) methyl] sulfinyl] -1H-benzimidazole
6-Methoxy-2 - [ (4-methoxy-3,5-dimethyl-1-oxidized-2-pyridyl) methyl] sulfinyl-1H-benzimidazole, which is the chemical name of the drug pantoprazole. Its main use is quite critical and is widely used in the field of medicine.
This compound is mainly used to treat diseases related to gastric acid. First, it can be used in the treatment of gastric ulcers. Patients with gastric ulcers suffer from pain and bleeding due to damage to gastric mucosa and acid invasion. Pantoprazole can inhibit gastric acid secretion, reduce the stimulation of gastric acid to the ulcer surface, and help ulcer healing. Second, this medicine is also commonly used in the treatment of duodenal ulcers. The cause of duodenal ulcers is mostly related to excessive gastric acid secretion, and pantoprazole can reduce the amount of gastric acid and relieve patient discomfort. Third, the treatment of reflux esophagitis is also indispensable. Reflux esophagitis damages the esophageal mucosa due to acid reflux. Pantoprazole can reduce reflux symptoms and promote esophageal mucosal repair by inhibiting gastric acid.
In addition, 6-methoxy-2- [ (4-methoxy-3,5-dimethyl-1-oxo-2-pyridyl) methyl] sulfinyl-1H-benzimidazole also plays an important role in the combined treatment regimen for the eradication of Helicobacter pylori. Helicobacter pylori infection is closely related to a variety of gastric diseases. Pantoprazole can regulate the pH in the stomach, create a good environment for antibiotics to work, and improve the eradication rate of Helicobacter pylori.
What are the physical properties of 6-Methoxy-2- [ (4-methoxy-3, 5-dimethyl-1-oxido-2-pyridinyl) methyl] sulfinyl] -1H-benzimidazole
6-Methoxy-2 - [ (4-methoxy-3,5-dimethyl-1-oxidized-2-pyridyl) methyl] sulfinyl-1H-benzimidazole, which is an organic compound. Its physical properties are quite critical, and it is related to many properties and applications of this compound.
Looking at its properties, it is mostly in a solid form at room temperature and pressure, which is convenient for storage and transportation. In addition, its melting point is also an important physical parameter. After rigorous determination, the melting point is in a specific temperature range, which is of great significance for the purification and identification of compounds. By measuring the melting point, the purity of the compound can be determined. If the melting point is close to the theoretical value and the melting range is narrow, it indicates that the purity is very high.
In terms of solubility, this compound exhibits different solubility properties in organic solvents. In some common organic solvents, such as ethanol and dichloromethane, it has certain solubility, but it is not good in water. This property needs to be considered in the synthesis, separation and application of compounds. In organic synthesis reactions, it is crucial to choose a suitable solvent. The solvent must not only dissolve the reactants, but also facilitate the separation of the reaction and the product.
In addition, the density of the compound is also a physical property. Although the density value seems ordinary, it is of great significance in chemical production, preparation and other fields. For example, in the production process of the preparation, knowing the density helps to precisely control the amount of material and ensure the uniform and stable quality of the product.
From the perspective of crystal structure, the crystal structure of the compound is analyzed by techniques such as X-ray diffraction. The crystal structure determines its many physical and chemical properties, including stability, solubility and reactivity. In-depth investigation of the crystal structure can lay a solid foundation for its further research and application.
What is the preparation method of 6-Methoxy-2- [[ (4-methoxy-3, 5-dimethyl-1-oxido-2-pyridinyl) methyl] sulfinyl] -1H-benzimidazole
6-Methoxy-2- [ (4-methoxy-3,5-dimethyl-1-oxidized-2-pyridyl) methyl] sulfinyl] -1H-benzimidazole, the preparation method is as follows:
First take an appropriate amount of 4-methoxy-3,5-dimethyl-2-chloropyridine, place it in a reactor, add an appropriate amount of organic solvent, such as dichloromethane, stir to dissolve. Slowly add a certain amount of (6-methoxy-1H-benzimidazole-2-yl) methanol. During this process, pay close attention to the reaction temperature and maintain it between about 20 ° C and 30 ° C. Then, add an appropriate amount of alkali, such as potassium carbonate, to promote the reaction. The reaction lasts for about 2 to 3 hours, stirring from time to time, so that the material is fully in contact with the reaction.
After the reaction is completed, pour the reaction solution into the separation funnel, wash it with an appropriate amount of water several times, and separate the organic phase. Then dry the organic phase with anhydrous sodium sulfate, filter out the desiccant, and remove the organic solvent by reduced pressure distillation to obtain the intermediate. < Br >
Then, place this intermediate in another reaction vessel, add an appropriate amount of oxidant, such as m-chloroperoxybenzoic acid, and control the reaction temperature between 0 ° C and 5 ° C. After about 1 to 2 hours of reaction, monitor the reaction progress by thin layer chromatography. When the reaction is complete, wash the reaction solution with sodium bicarbonate solution to remove excess oxidant. The organic phase is separated again and processed by drying, vacuum distillation and other steps to finally obtain 6-methoxy-2-[ (4-methoxy-3,5-dimethyl-1-oxidized-2-pyridyl) methyl] sulfinyl] -1H-benzimidazole products. During the whole preparation process, it is necessary to pay attention to the reaction conditions of each step and operate accurately to obtain products with higher yields.
What is the price range of 6-Methoxy-2- [[ (4-methoxy-3, 5-dimethyl-1-oxido-2-pyridinyl) methyl] sulfinyl] -1H-benzimidazole in the market?
I look at your question, I am inquiring about 6-methoxy-2- [ (4-methoxy-3,5-dimethyl-1-oxidized-2-pyridyl) methyl] sulfinyl] -1H-benzimidazole in the market price range. However, the price of this product often changes for many reasons.
First, the quality of its quality can lead to different prices. High quality, the price is high; quality is slightly inferior, the price is low.
Second, the amount of purchase also affects the price. If the purchase volume is large, the merchant may give a discount, and the price can be reduced; if the purchase volume is small, the price may be as usual.
Third, the state of market supply and demand is also the key. If there are many people who want it, and the supply is limited, the price may be raised; if the supply exceeds the demand, the price may be depressed.
Fourth, the price is different between manufacturers and brands. Well-known manufacturers, because of their reputation and craftsmanship, the price may be high; new or unknown, the price may be lower.
As far as I know, this product is in the market, and the price per gram may range from tens of yuan to hundreds of yuan. If purchased in large quantities, kilograms, or thousands of yuan per kilogram. However, this is only an approximation, and the actual price shall be subject to the real-time market. For the exact price, you can consult the chemical raw material supplier, chemical trading platform, or relevant industry practitioners, who can tell you the real price according to the current situation.