6-(2-chloro-5-fluoro-4-pyrimidinyl)-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole

This is about the chemical structure of 6 - (2 - chloro - 5 - fluoro - 4 - pyrimidinyl) -4 - fluoro - 2 - methyl - 1 - (1 - methylethyl) -1H - benzimidazole. To clarify its structure, it is necessary to analyze it according to the nomenclature of organic chemistry.
"Benzimidazole" is the parent nucleus, which is the structure of a nitrogen-containing heterocycle, which is formed by fusing the benzene ring with the imidazole ring. "1H - benzimidazole" indicates that the hydrogen atom is attached to the nitrogen atom at the 1st position of the imidazole ring.
"6- (2-chloro-5-fluoro-4-pyrimidinyl) " is shown at the 6th position of benzimidazole with a 2-chloro-5-fluoro-4-pyrimidinyl substituent. The pyrimidine ring is a six-membered nitrogen-containing heterocycle with a chlorine atom at the 2nd position and a fluorine atom at the 5th position, and this pyrimidine group is connected to the benzimidazole 6th position.
"4-fluoro-2-methyl-1- (1-methylethyl) " means that the benzimidazole ring has fluorine atoms at 4 positions, methyl at 2 positions, and 1-methylethyl at 1 position (ie isopropyl).
Overall, the chemical structure of this compound is based on benzimidazole as the core, and there are chlorine, fluorine, methyl, isopropyl and chlorine-containing pyrimidine groups at specific positions. This structure endows the compound with specific chemical and physical properties, which may be of great significance in the fields of organic synthesis, medicinal chemistry, etc.

6 - (2 - chloro - 5 - fluoro - 4 - pyrimidinyl) - 4 - fluoro - 2 - methyl - 1 - (1 - methylethyl) - 1H - benzimidazole, this is an organic compound that plays an important role in many fields.
In the field of pharmaceutical research and development, it may have significant pharmacological activity. Or it can act as a key intermediate for the preparation of drugs with specific curative effects. After structural modification and modification, innovative drugs with therapeutic effects for specific diseases, such as tumors and inflammation, may be obtained. For example, by adjusting the functional group at a specific location of the compound, it can precisely bind to disease-related targets, thereby exhibiting the effects of inhibiting tumor cell proliferation and modulating immune responses.
In the field of materials science, this compound also has potential uses. Because of its unique structure, or with specific electrical and optical properties. Or it can be used to prepare organic semiconductor materials, which can be used in organic Light Emitting Diode (OLED), organic field effect transistor (OFET) and other devices, injecting new vitality into the development of electronic devices. Because of the benzimidazole and pyrimidine groups in its structure, it may endow the material with good charge transfer performance and stability.
In the field of pesticides, there are also applications. It may be able to inhibit or kill some pests and pathogens by virtue of its special chemical structure. Through rational design and optimization, it is expected to develop new pesticides with high efficiency, low toxicity and environmental friendliness to escort agricultural production.
In addition, in the field of organic synthetic chemistry, as a compound with a special structure, it can provide new research ideas and methods for organic synthesis reactions. Chemists can use its activity check point to carry out various novel chemical reactions, expand the boundaries of organic synthesis, and provide possibilities for the preparation of more complex organic compounds.

To prepare 6 - (2 - chloro - 5 - fluoro - 4 - pyrimidinyl) - 4 - fluoro - 2 - methyl - 1 - (1 - methylethyl) - 1H - benzimidazole, the method is as follows:
First take an appropriate amount of 4 - fluoro - 2 - methyl - 1 - (1 - methylethyl) - 1H - benzimidazole, placed in a clean reactor, dissolved in an appropriate organic solvent, this organic solvent can be selected dichloromethane, N, N - dimethylformamide, etc , depending on the reaction conditions and needs.
The second dose is 2-chloro-5-fluoro-4-halogenated pyrimidine, the halogen atom can be bromine or iodine, and the molar ratio of benzimidazole should be precisely prepared, usually maintained between 1.0 and 1.5:1 to ensure the full progress of the reaction.
Add an appropriate amount of base, such as potassium carbonate, sodium carbonate, etc., the effect of base is to promote the reaction, and the dosage also needs to be carefully considered, generally 1.2 to 1.8 times the molar number of benzimidazole. < Br >
Then, the reaction system is heated to a suitable temperature, usually 50-100 ° C, and stirred continuously at this temperature for about 3-8 hours. During the reaction, the reaction process needs to be closely monitored, which can be observed by thin layer chromatography (TLC) or high performance liquid chromatography (HPLC).
After the reaction is completed, the reaction solution is cooled to room temperature, poured into an appropriate amount of water, and the product is extracted with an organic solvent. After multiple extractions, the organic phases are combined, and then dried with anhydrous sodium sulfate. After filtering out the desiccant, the organic solvent is removed by distillation under reduced pressure to obtain a crude product.
Finally, the crude product is purified by column chromatography or recrystallization, and a suitable eluent or solvent is selected to obtain pure 6- (2-chloro-5-fluoro-4-pyrimidinyl) -4-fluoro-2-methyl-1- (1-methethyl) -1H-benzimidazole. The whole process is operated in a well-ventilated experimental environment, and the chemical experimental safety regulations are strictly adhered to to to ensure the smooth and safe experiment.

6- (2-chloro-5-fluoro-4-pyrimidinyl) -4-fluoro-2-methyl-1- (1-methylethyl) -1H-benzimidazole This substance has unique physical properties. Looking at its shape, under normal conditions, it may be white to off-white crystalline powder, delicate and uniform, with a soft luster and no noise and foreign matter.
When it comes to the melting point, the melting point is in a specific range, about [X] ° C. At this temperature, the solid phase will gradually transform into a liquid phase, and the intermolecular forces will change. The boiling point is also related to it. It is restricted by the molecular structure and interaction. Under [specific conditions], it can reach [Y] ° C. At this time, the liquid phase molecules obtain enough energy to escape from the liquid surface and form a gaseous state.
In terms of solubility, this substance behaves differently in organic solvents. In polar organic solvents such as ethanol and acetone, it has a certain solubility. Because its molecular structure contains polar groups, it can be dissolved with polar solvent molecules by hydrogen bonds and dipole-dipole interactions. However, in non-polar solvents such as n-hexane, the solubility is very small, because the intermolecular forces between the two do not match.
On the density, the measured value is about [Z] g/cm ³. This value reflects the mass of the substance per unit volume and is related to the degree of molecular accumulation. If the molecular structure is regular and closely arranged, the density will be relatively high; if it is not, it will be low.
In addition, its stability is also an important property. It can exist stably under conventional environmental conditions, such as normal temperature and pressure, dry without strong light. In case of strong acid, strong alkali or high temperature and strong oxidation environment, the molecular structure may change, resulting in changes in properties. All kinds of physical properties are determined by their molecular structure, and each property is related to each other. When applied in many fields such as chemistry and medicine, it needs to be carefully considered.

Guanfu 6 - (2 - chloro - 5 - fluoro - 4 - pyrimidinyl) -4 - fluoro - 2 - methyl - 1 - (1 - methylethyl) -1H - benzimidazole is worth exploring in the market prospect.
Since the field of pharmaceutical research and development, benzimidazole compounds often have a variety of biological activities, such as antibacterial, antiviral, antitumor, etc. This compound contains specific substituents, or has unique effects in the treatment of certain diseases. At present, the pharmaceutical industry is in great demand for new specific drugs. If this compound is deeply researched and developed, and its exact efficacy and safety can be confirmed in pharmacological experiments, it will definitely gain a place in the market. In the direction of anti-tumor drug research and development, many studies focus on novel structural compounds to find breakthroughs. The unique structure of this compound may become a new hope, which is expected to open up new treatment paths, so the pharmaceutical market has a bright future.
The field of pesticides should not be underestimated. Benzimidazoles are often used as fungicides and insecticides in pesticides. The chlorine, fluorine and other substituents of this compound may give it unique bactericidal and insecticidal activities. Nowadays, there is a growing demand for high-efficiency, low-toxicity and environmentally friendly pesticides in agriculture. If it can meet this requirement and the effect is verified by field tests, there is also a broad space in the pesticide market, which can help agricultural production reduce and increase efficiency.
However, the road ahead for its market is not smooth. The research and development stage requires a lot of manpower, material resources and time to clarify its mechanism of action and toxicological properties. And the market competition is fierce, with many similar or similar functional compounds competing. Only by virtue of excellent performance, reasonable cost and perfect marketing activities can we gain a firm foothold in the market and open up a prosperous scene.