5 Phenyl 1h Imidazole
quinoline thiophene imidazole thiazole

5-Phenyl-1H-imidazole

    Specifications

    HS Code

    187957

    Chemical Formula C9H8N2
    Molecular Weight 144.17 g/mol
    Appearance Solid
    Odor Odorless (usually)
    Melting Point 178 - 182 °C
    Solubility In Water Poorly soluble
    Solubility In Organic Solvents Soluble in many organic solvents like ethanol, DMSO
    Pka ~14 (approximate value for imidazole ring)
    Logp Approx. 1.5 - 2 (lipophilicity measure)
    Stability Stable under normal conditions, may decompose on heating

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    General Information
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    Frequently Asked Questions

    As a leading 5-Phenyl-1H-imidazole supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 5-Phenyl-1H-imidazole?
    5-Phenyl-1H-imidazole is an organic compound with a wide range of uses. This compound is often used as a key intermediate in drug synthesis in the field of medicinal chemistry. Due to the unique structure of the imidazole ring and the benzene ring, it is endowed with various biological activities and can interact with specific targets in organisms, thus laying the foundation for the development of new drugs, such as the creation of antibacterial, antiviral, and anti-tumor drugs.
    In the field of materials science, 5-Phenyl-1H-imidazole also has important uses. It can participate in the preparation of functional materials. Due to its structural properties, it can improve some properties of materials, such as enhancing their stability, conductivity, or optical properties. In the synthesis of polymer materials, it may be used as a crosslinking agent or modifier to optimize the physical and chemical properties of materials to meet the special needs of materials in different fields.
    In organic synthetic chemistry, 5-Phenyl-1H-imidazole is an important building block for the construction of complex organic molecules. With its active reaction check point, it can introduce other functional groups through various chemical reactions, such as nucleophilic substitution, electrophilic substitution, etc., to expand the structural diversity of molecules and help synthesize organic compounds with specific functions and structures.
    To sum up, 5-Phenyl-1H-imidazole plays a key role in drug discovery, material preparation, and organic synthesis, and is of great significance to promoting scientific research and technological development in related fields.
    What are the physical properties of 5-Phenyl-1H-imidazole?
    5-Phenyl-1H-imidazole is a kind of organic compound. It has unique physical properties, which are described in detail by you.
    Looking at its appearance, it is often white to light yellow crystalline powder, delicate and even, slightly shiny in the sun, like fine jade powder. Its smell, although not strong and pungent, but also has a special smell. Sniffing it slightly, you can feel an elegant and slightly fragrant smell, just like finding a unique herbal fragrance in a deep herb.
    When it comes to the melting point, the melting point of this substance is quite high, about 140-145 degrees Celsius. When the temperature gradually rises to the melting point, the original solid state of 5-phenyl-1H-imidazole slowly melts into a clear liquid like winter snow in the warm sun. Its boiling point is higher, and under normal pressure, it needs a higher temperature to boil, which makes it stable at ordinary ambient temperatures.
    In terms of solubility, 5-phenyl-1H-imidazole exhibits good solubility in organic solvents such as ethanol and dichloromethane. Taking ethanol as an example, an appropriate amount of 5-phenyl-1H-imidazole is placed in ethanol, and with a little stirring, it is quickly dissolved into water like salt to form a uniform and transparent solution. However, in water, its solubility is relatively limited, and only a very small amount can be dissolved in water, just like in the vast lake water, put a little sand and stones that are not easy to melt.
    In addition, the density of 5-phenyl-1H-imidazole is moderate, slightly heavier than water. When it is placed in water, it can be seen that it sinks slowly, like a stone falling into the abyss, and sinks quietly to the bottom of the water. This density characteristic is important to consider when many operations involve separation, mixing, etc.
    5-Phenyl-1H-imidazole chemical synthesis methods
    5-Phenyl-1H-imidazole is also an organic compound. The method of synthesis has been known in ancient times, and it is now the end of Junchen's theory.
    First, benzaldehyde and glyoxal are used as starting materials, and ammonia or ammonium salts are added to carry out a condensation reaction to obtain 5-phenyl-1H-imidazole. The method is as follows: In a suitable solvent, such as ethanol or water, benzaldehyde, glyoxal and ammonia or ammonium salts are placed, and heated to a suitable temperature, usually between 50 and 100 degrees Celsius. During the reaction, the raw materials interact and form 5-phenyl-1H-imidazole through the process of condensation. After the reaction is completed, the pure product is obtained by conventional separation methods, such as extraction, crystallization, etc.
    Second, the product is prepared by cyclization of o-phenylenediamine and acetophenone as raw materials. The o-phenylenediamine and acetophenone are placed in a suitable solvent, such as toluene, and an appropriate amount of catalyst, such as p-toluenesulfonic acid, is added. During this process, the nucleophilic addition of o-phenylenediamine and acetophenone first occurs, and then it is cyclized within the molecule to form 5-phenyl-1H-imidazole. At the end of the reaction, the product is cooled and purified by filtration, washing and recrystallization.
    Third, phenylacetonitrile and formamide are used as the starting materials and synthesized through a series of reactions. First, phenylacetonitrile and formamide react under the catalysis of strong bases, such as sodium hydride, to form an intermediate product. Then, the intermediate product is heated and cyclized to obtain 5-phenyl-1H-imidazole. In this synthesis path, the reaction conditions need to be carefully controlled. The amount of strong base, reaction temperature and time are all related to the yield and purity of the product. After the reaction, appropriate separation and purification methods are also required to obtain pure 5-phenyl-1H-imidazole.
    All synthesis methods have their own advantages and disadvantages, and they need to be followed according to actual conditions, such as the availability of raw materials, cost, and purity requirements of products.
    5-Phenyl-1H-imidazole in what areas?
    5-Phenyl-1H-imidazole is useful in many fields. In the field of medicine, this compound has many wonders. Because of its specific chemical structure and activity, it can be used as a key intermediate for drug research and development. Taking the synthesis of antimalarial drugs as an example, it can contribute to the construction of active ingredients, help resist the invasion of malaria parasites, and protect the well-being of the people.
    In the field of materials science, 5-phenyl-1H-imidazole has also emerged. It can be used to prepare special polymer materials because it can be cleverly combined with many monomers to improve the properties of materials. Such as enhancing the stability and durability of materials, making them immovable in different environments, suitable for aerospace, automobile manufacturing and other industries that require strict materials.
    In the field of organic synthesis, this substance is an indispensable reagent. With its unique reactivity, it can trigger various organic reactions and assist chemists in synthesizing organic compounds with complex structures and unique functions. Like a sharp blade in the hands of skilled craftsmen, it helps to create countless exquisite organic molecules and fuels the development of organic chemistry.
    Furthermore, in the field of biochemical research, 5-phenyl-1H-imidazole also has its uses. It can be used as a biological probe to detect specific molecules or biological processes in living organisms, providing a powerful tool for in-depth understanding of the mysteries of life and helping scientists uncover the mystery of life phenomena.
    What is the market outlook for 5-Phenyl-1H-imidazole?
    5-Phenyl-1H-imidazole is one of the organic compounds. Looking at its market prospects, it is quite impressive.
    In the field of medicine, this compound shows unique potential. Its structural characteristics endow it with certain biological activities, or can be used as a key intermediate in drug research and development. With the current desire for innovative drugs in the pharmaceutical industry, many pharmaceutical companies and scientific research institutions are focusing on the exploration of new compounds. 5-Phenyl-1H-imidazole may provide novel ideas and opportunities in the development of anti-inflammatory and anti-tumor drugs. Due to the raging of inflammation and tumors in modern society, the demand for effective therapeutic drugs is eager, so it is expected to win a place in the pharmaceutical market.
    In the field of materials science, 5-phenyl-1H-imidazole has also emerged. Because of its specific electronic structure and chemical stability, it may be applied to the creation of new functional materials. For example, in the field of optical materials, it may improve the optical properties of materials, making materials have better luminous efficiency or photostability. With the rapid development of science and technology, the demand for high-performance materials is increasing day by day, and there is room for this compound to expand in the materials market.
    However, its marketing activities are not smooth sailing. The complexity of the synthesis process, or the high production cost, is a major obstacle. And the market competition is fierce, and there are many similar or alternative compounds. To make its market prospects fully bloom, researchers need to improve the synthesis process, reduce costs and increase efficiency, and enterprises need to accurately grasp market demand, strengthen promotion and application development, in order to fully tap the market potential of 5-phenyl-1H-imidazole, gain a firm foothold in the market, and seek long-term development.