5-nitro-2-(propan-2-yl)-1H-imidazole

The chemical structure of 5-nitro-2- (propan-2-yl) -1H-imidazole is as follows. This compound belongs to the imidazole derivative, and the imidazole ring is its core structure. It has the shape of a five-membered nitrogen-containing heterocycle with two nitrogen atoms in the ring. Its structure is wonderful, just like the ancient ring, although it is small but very delicate.
At the second position of the imidazole ring, there is an isopropyl group (propan-2-yl). This isopropyl group is attached to the ring side in a branched state as an ornament on the ring. The isopropyl group is composed of three carbon atoms, which are divided in a weighted manner, just like the branches of a tree, and the carbon atoms in the middle are connected to the imidazole ring.
At the 5th position of the imidazole ring, there is a nitro group. The nitro group is a strong electron-absorbing group whose structure is connected by one nitrogen atom and two oxygen atoms, showing a special resonance structure, like a mysterious rune. The existence of this nitro group has a great impact on the properties of compounds, such as electron cloud distribution and chemical activity.
From a comprehensive perspective, the chemical structure of 5-nitro-2- (propan-2-yl) -1H-imidazole, with imidazole ring as the base and isopropyl and nitro groups as the decorations, is combined to form a unique chemical morphology, which has its unique significance and characteristics in the field of chemistry.

5 - nitro - 2 - (propan - 2 - yl) -1H - imidazole, that is, 5 - nitro - 2 - isopropyl - 1H - imidazole, this is an organic compound. Its physical properties are as follows:
1. ** Properties **: Usually a crystalline solid, it is white to light yellow powder. Due to the arrangement and interaction of atoms in its molecular structure, a specific lattice structure is formed between molecules, and light scattering and other factors cause it to appear like this.
2. ** Melting point **: The melting point is in a specific range, about [X] ° C. When the temperature rises to the melting point, the molecules are energized, the vibration intensifies, which is enough to overcome the lattice energy, the lattice structure disintegrates, and the substance changes from solid to liquid. This property is related to the intermolecular forces, such as van der Waals forces, hydrogen bonds, etc. These forces maintain the molecules in the lattice, and the strength of the forces determines the melting point.
3. ** Boiling point **: The boiling point is about [X] ° C. When the boiling point is reached, the vapor pressure generated inside the liquid is equal to the external pressure, and the liquid vaporizes violently. The boiling point is affected by the molecular weight and intermolecular forces. The molecular weight and intermolecular forces of the compound determine its boiling point value.
4. ** Solubility **: Good solubility in organic solvents, such as common ethanol, acetone, etc. Due to the fact that the molecule of this compound has a certain polarity, it can form a similar intermolecular force to the molecules of organic solvents, following the principle of "similar miscibility". However, the solubility in water is not good, because the hydrophobic isopropyl part is large, which hinders the formation of effective interactions with water molecules.
5. ** Density **: The density is [X] g/cm ³, which is determined by the molecular weight and the degree of compaction of the molecule in solid or liquid state. If the molecular mass is large and the compaction is tight, the density is relatively high.

5 - nitro - 2 - (propan - 2 - yl) -1H - imidazole, the Chinese name is often 5 - nitro - 2 - isopropyl - 1H - imidazole. This substance is widely used in the field of medicine and is an important organic synthesis intermediate. It is often involved in the creation of antibacterial and antifungal drugs. Take some imidazole antifungal drugs as an example, the structural core contains this ingredient, which interferes with the synthesis or metabolism of fungal cell membranes, exhibits antifungal effect, and has a significant effect on infections caused by common fungi.
In the field of pesticides, it is also used as an intermediate for the synthesis of specific insecticides and fungicides. Due to its unique mechanism of action against certain pests and pathogens, it can effectively inhibit or kill them, and has relatively little impact on the environment, which is in line with the development trend of green pesticides.
In the field of materials science, it can participate in the preparation of high-performance polymers and composites. Due to its special structure, it can endow materials with excellent characteristics such as better thermal stability and mechanical properties, making them suitable for applications in aerospace, automobile manufacturing and other fields that require strict material properties.
In addition, in chemical research, 5-nitro-2-isopropyl-1H-imidazole is often used as a model compound to help researchers explore basic chemical problems such as organic reaction mechanisms and molecular interactions, providing theoretical support for the development of chemistry.

5-Nitro-2- (propan-2-yl) -1H-imidazole, that is, 5-nitro-2-isopropyl-1H-imidazole, is synthesized as follows:
First, you can start from imidazole. The structure of imidazole is relatively stable. To introduce isopropyl at the 2nd position and nitro at the 5th position, you need to proceed in steps.
Consider introducing isopropyl at the 2nd position first. Nucleophilic substitution can be used to select suitable isopropylation reagents, such as isopropyl halides (such as isopropyl bromide or isopropyl chloride). Under alkaline conditions, the nitrogen atom of imidazole has nucleophilicity and can react with isopropyl halide. A weak base such as potassium carbonate is used as an acid binding agent, and the reaction system is heated in an appropriate organic solvent (such as N, N-dimethylformamide, DMF) to promote the reaction to occur and generate 2-isopropyl imidazole. This step requires attention to the control of the reaction temperature and time. If the temperature is too high, side reactions may be initiated, and if the time is too short, the reaction will be incomplete.
Next, the 5-position nitration of 2-isopropyl imidazole is carried out. The commonly used reagent for nitration reaction is a mixed acid system of concentrated nitric acid and concentrated sulfuric acid. Slowly add 2-isopropyl imidazole to the cooled mixed acid and react at low temperature. Because nitro is a strong electron-absorbing group, the introduction of nitro will reduce the density of the electron cloud of the benzene ring and further weaken the reactivity, which is conducive to controlling the reaction at the 5 position. However, the temperature needs to be strictly controlled during the reaction to prevent side reactions such as polynitrogenation due to excessive temperature. After the reaction, the target product 5-nitro-2-isopropyl-1H-imidazole can be obtained by conventional post-treatment operations, such as pouring ice water into the quenching reaction, and then performing separation and purification steps such as extraction, washing, drying, and column chromatography.
It is also possible to nitrate imidazole first, and then introduce isopropyl. However, the strong electron-absorbing action of nitro will reduce the electron cloud density of the imidazole ring, and the subsequent isopropylation reaction may be more difficult, requiring more violent reaction conditions, which may lead to more side reactions. Therefore, the route of isopropylation and then nitration is more commonly used.

5-Nitro-2- (isopropyl) -1H-imidazole, when storing, several things should be taken care of.
First, in storage, it should be placed in a cool and dark place to cover this substance from heat and light. If exposed to high temperature and strong light, its molecular structure may be damaged, causing property variation and efficiency attenuation. For example, if it is placed in a place with hot sun and hot summer, its quality will be damaged.
Second, the storage place must be dry. This compound is prone to react in case of moisture, or cause hydrolysis and other changes, resulting in impurities, which will damage its purity and quality. If it is immersed in a damp place with water vapor, its quality will be damaged in different days.
Third, when using it, protective gear is indispensable. Because it may be irritating, it can be connected to the skin and mucous membranes, which can cause discomfort or even injury. Therefore, in front of protective clothing, wear gloves and goggles to avoid direct contact with the body.
Fourth, the operating environment is also important. It is suitable for well-ventilated places to avoid the accumulation of volatile gas, which will cause air pollution and endanger the health of the operator.
Fifth, the residue after use should not be discarded at will. In accordance with relevant regulations, properly dispose of it to avoid polluting the environment and leaving behind disasters.
All these things are related to the use of 5-nitro-2- (isopropyl) -1H-imidazole, and they should be done carefully, so that the security is safe and the use of everything is made.