5-METHOXY-1H-BENZO[D]IMIDAZOLE-2-THIOL

5 - METHOXY - 1H - BENZO [D] IMIDAZOLE - 2 - THIOL, the Chinese name is often 5 - methoxy - 1H - benzo [d] imidazole - 2 - thiol. Its chemical structure is composed of three important fragments.
The first is the benzimidazole ring, which is the core structure of the compound. The benzimidazole ring is formed by fusing the benzene ring and the imidazole ring, and has a unique conjugated system. The benzene ring is a six-membered carbon ring, which is connected by six carbon atoms with conjugated double bonds. It is a planar hexagon with aromatic properties and good stability. The imidazole ring is a five-membered nitrogen-containing heterocycle with two nitrogen atoms, one of which exists in the form of a secondary amine and the other in the form of a tertiary amine. Due to the distribution characteristics of electron clouds in the ring, it is also aromatic. The presence of the benzimidazole ring endows compounds with a variety of potential biological activities and reactive properties, and has been widely studied in the fields of medicinal chemistry and materials science.
The methoxy group of order 5 is attached to the 5-position of the benzimidazole ring. Oxygen atom and benzene ring carbon atom are connected by covalent bond, because the electronegativity of oxygen atom is higher than that of carbon atom, methoxy group has electron donor induction effect and electron donor conjugation effect, which can change the electron cloud distribution of benzimidazole ring and affect the physical and chemical properties of the compound, such as improving lipophilicity, enhancing its ability to penetrate biofilms, and having a significant impact on the biological activity and solubility of the compound.
The end is a thiol group at the 2-position. The thiol group (-SH) is connected to the 2-position of the imidazole ring. The sulfur atom is connected to the imidazole ring carbon atom, the sulfur atom has a large radius, the electronegativity is relatively small compared to the oxygen atom, and the S-H bond energy in the sulfhydryl group is relatively small, which makes the sulfhydryl group acidic to a certain extent, and prone to oxidation, nucleophilic substitution and other reactions. It plays an important role in organic synthesis and chemical reactions in vivo. For example, it can form coordination bonds with metal ions and participate in the structural and functional regulation of biological macromolecules such as proteins.
In summary, the chemical structure of 5-methoxy-1H-benzo [d] imidazole-2-thiol is unique, and its various parts interact, giving it a variety of physical and chemical properties and potential application

5-Methoxy-1H-benzo [d] imidazole-2-thiol, this is an organic compound. It has some unique physical properties.
Looking at its properties, it is mostly solid at room temperature and pressure, and is often powdery, delicate and light, easy to use and operate. The color of this compound is usually almost white or slightly yellowish, and the color is pure and simple.
When it comes to solubility, its solubility in water is quite limited, which is due to the characteristics of its molecular structure. Its hydrophobic groups account for a large proportion, making it difficult to dissolve in water with strong polarity. However, in organic solvents, such as ethanol, dichloromethane, etc., it shows a certain solubility. Ethanol is a common organic solvent with moderate polarity. It can interact with 5-methoxy-1H-benzo [d] imidazole-2-thiol molecules through hydrogen bonds, van der Waals forces, etc. Therefore, the compound can be moderately dissolved in ethanol.
The melting point is also an important physical property. Its melting point is relatively high, and a specific temperature is required to melt it from a solid state to a liquid state. This higher melting point is due to the existence of strong interaction forces between molecules, such as hydrogen bonds 、π - π accumulation. These effects tightly bind the molecule and require more energy to break it, causing the melting point to rise. The boiling point is higher, and in order to make it boil into a gaseous state, more considerable energy needs to be provided.
In addition, the density of this compound is slightly larger than that of ordinary organic solvents. Although it is not extremely heavy, in the experimental operation, the weighing, transfer and other steps also need to be based on its density characteristics, and the dosage should be precisely controlled to achieve the desired effect of the experiment.
Its stability is good in the solid state, but it may be affected under high temperature, high humidity or specific chemical environment. Conditions such as light may also cause chemical reactions to occur, resulting in changes in its structure and properties. Therefore, when storing this compound, it is often necessary to choose a dry, cool and dark place to maintain the stability of its physical properties and chemical structure.

5-Methoxy-1H-benzo [d] imidazole-2-mercaptan, which is useful in many fields.
In the field of medicine, it is often the key raw material for synthesizing drugs. Because of its unique chemical structure, it has potential biological activity, and may help develop new drugs for antibacterial, antiviral, and anti-tumor. As the ancient saying goes, it is "the foundation for doctors to make good medicines, and it may be of great use in the fight against diseases." In the process of modern pharmaceutical research and development, the birth of many new compounds often relies on such basic raw materials, such as craftsmen carving beautiful jade, which starts and ends up being a great tool.
In the field of materials science, it also has outstanding performance. It can be used to prepare materials with special functions, such as materials with adsorption or identification properties for certain substances. Like an ancient mechanism, it can accurately capture or distinguish specific objects. Such materials are of great significance in environmental monitoring, material separation and purification, etc., and can help craftsmen accurately screen the things they need to remove barren and store cyanine.
In the chemical industry, 5-methoxy-1H-benzo [d] imidazole-2-thiol can be used as a catalyst or auxiliary. In chemical reactions, it is like an ancient marching general, guiding the reaction direction, speeding up the reaction process, and improving product quality and yield. Chemical production is related to the national economy and people's livelihood. The help of this material is like a spent force, making production more efficient and skills more exquisite.

To prepare 5-methoxy-1H-benzo [d] imidazole-2-mercaptan, follow the following ancient method. First take an appropriate amount of 2-amino-4-methoxyaniline and place it in a clean reaction vessel. Take an appropriate amount of glacial acetic acid as the solvent, stir well, so that 2-amino-4-methoxyaniline is fully dissolved to form a uniform solution.
Take another appropriate amount of carbon disulfide and slowly drop it into the above solution. When adding dropwise, pay close attention to the changes in the reaction system, control the dripping speed, and do not make the reaction too violent. After adding dropwise, seal the reaction vessel and move it to a constant temperature water bath. Maintain the water bath temperature in a suitable range, usually between 60 and 80 degrees Celsius, so that it can fully react at this temperature. This process requires continuous stirring to promote the uniform progress of the reaction, which lasts about several hours (about 3 to 5 hours).
After the reaction is completed, the reaction solution is removed from the water bath and cooled to room temperature. Then, an appropriate amount of sodium hydroxide solution is added to the reaction solution, and the pH of the solution is adjusted to the alkaline range, which is about pH = 9-10. At this time, solid substances can be seen gradually precipitating. The mixture is then filtered by suction to separate the solid from the liquid. The resulting solid is the crude product. < Br >
To obtain pure 5-methoxy-1H-benzo [d] imidazole-2-mercaptan, the crude product is recrystallized with an appropriate amount of ethanol as a solvent. The crude product is placed in ethanol, heated to dissolve, and a hot saturated solution is formed. Subsequently, the solution is slowly cooled, and after the crystals are fully analyzed, suction filtration is carried out again. The resulting crystals are washed several times with a small amount of cold ethanol to remove attached impurities. Finally, the crystals were placed in an oven and dried at a suitable temperature (about 50-60 degrees Celsius) to obtain a pure 5-methoxy-1H-benzo [d] imidazole-2-thiol product.

5-Methoxy-1H-benzo [d] imidazole-2-mercaptan, which is in the market, its scene is as follows. In recent years, the field of chemical industry has gradually developed the need for special organic compounds. This 5-methoxy-1H-benzo [d] imidazole-2-mercaptan has emerged in many fields such as pharmaceutical research and development, materials science and other fields due to its unique chemical structure.
In pharmaceutical research and development, researchers have investigated its potential biological activity, or it can be used as a lead compound. After modification and optimization, it is expected to become a new type of drug to treat specific diseases. In materials science, it can participate in the synthesis of polymer materials, endowing materials with specific electrical, optical or mechanical properties, so it has attracted the attention of researchers and enterprises.
There are more and more people seeking it in the market, but its preparation is not easy. The synthesis process is complicated, the raw materials are rare and expensive, and the yield is also constrained by many factors, resulting in limited supply. Although some enterprises and scientific research institutions are working hard to improve the synthesis method, the yield and cost are reduced, but the results are not obvious.
Under the heading, the supply and demand of 5-methoxy-1H-benzo [d] imidazole-2-thiol market is not coordinated, and the demand is greater than the supply. Because of the high price, only a few high-end application fields that are not sensitive to cost can be widely used. Over time, if the synthesis technology is broken through and the cost is greatly reduced, the market landscape may be extremely broad, leading to the tide of change in many fields.