5-iodo-2-methyl-1H-imidazole

1H-imidazole is a common five-membered nitrogen-containing heterocyclic compound with many unique chemical properties.
It is significantly alkaline, and the nitrogen atom in the ring can accept protons due to the presence of lone pair electrons, showing basic characteristics. This alkalinity makes it easy to form stable cations in acid solutions. This property is crucial in many chemical reactions and drug design fields, which can improve the water solubility and biological activity of compounds.
1H-imidazole is also aromatic, caused by a closed conjugate system with 6 π electrons satisfying the Shocker rule. Aroma gives it relative stability, making it less prone to addition reactions and more prone to electrophilic substitution reactions, similar to the properties of benzene rings. When electrophilic substitution occurs, the reaction mostly occurs in positions with higher electron cloud density.
Furthermore, 1H-imidazole can be used as a ligand to form metal complexes by means of the coordination of nitrogen atom lone pair electrons with metal ions. Such complexes are widely used in catalysis, materials science and other fields. For example, some metal-imidazole complexes can be used as high-efficiency catalysts to accelerate specific chemical reaction processes.
In addition, 1H-imidazole active hydrogen has a certain acidity. Under the action of appropriate bases, it can deprotonate and generate corresponding anions. This anion can be used as a nucleophilic agent in organic synthesis to participate in the reaction, broadening the application scope of 1H-imidazole in organic synthesis chemistry. Overall, the rich chemical properties of 1H-imidazole make it play an important role in many fields such as chemical industry, medicine, and materials.

1H-imidazole is an important heterocyclic organic compound. Although its common synthesis methods are not detailed in the ancient book "Tiangong Kaiwu", it can be explored according to the ancient chemical process ideas and current chemical knowledge.
The ancient method is often prepared by condensation and cyclization of nitrogen-containing and carbon-containing raw materials. If glyoxal, formaldehyde and ammonia are used as starting materials, these three react under appropriate conditions. Glyoxal has active carbonyl, formaldehyde is also reactive, and ammonia provides a nitrogen source. Under a certain temperature, pressure and catalyst, glyoxal and formaldehyde first condensate to form an unsaturated aldehyde intermediate, ammonia attacks the intermediate double bond or carbonyl, and nucleophilic addition occurs, and then through the molecular inner ring, the 1H-imidazole skeleton is obtained. Although this process is complex, it follows the basic laws of organic reactions.
There are also nitriles and amides as raw materials. Nitriles contain carbon and nitrogen triple bonds, which are electrophilic, and amides have nitrogen and oxygen atoms to participate in the reaction. Under the catalysis of the two bases, the nitrile group and the amide group are rearranged and cyclized to form 1H-imidazole. The base can capture hydrogen on amide nitrogen, generate nucleophilic nitrogen anions, attack the nitrile group, and initiate a series of reactions to construct an imidazole ring.
There is another method of reacting α-halogenated ketones with amidines. Halogen atoms in α-halogenated ketones are active and easily replaced by nucleophiles. Amidines have nitrogen atoms and are rich in electrons. Amidine nitrogen nucleophilic attack α-halogenated ketone carbonyl carbon, the halogen ions leave, and 1H-imidazole can be obtained through the steps of molecular inner ring and proton transfer.
There are various methods for synthesizing 1H-imidazole, with different raw materials and reaction conditions. However, it is necessary to fine-tune the reaction parameters to achieve high yield and purity. This is the key to organic synthesis, and it is also the inheritance and development of ancient chemical wisdom today.

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1H-tritium is an isotope of hydrogen and has unique physical properties. Its mass is heavier than that of ordinary hydrogen atoms. Because the nucleus contains two neutrons in addition to a proton, its atomic weight is about 3, which is three times that of ordinary hydrogen.
1H-tritium is radioactive and decays in beta decay. During the decay process, a neutron in the nucleus transforms into a proton, releasing an electron and an anti-neutrino at the same time. This radioactive property makes 1H-tritium have special uses in many fields, but it also needs to be properly protected against radiation hazards.
The boiling point and melting point of 1H-tritium are different from those of ordinary hydrogen. Due to the increase in mass and the increase in intermolecular force, its boiling point is about 20.62 K, and its melting point is about 13.99 K, both of which are higher than ordinary hydrogen. This property is of great significance in the fields of low temperature physics and superconductivity research.
In nature, the content of 1H-tritium is extremely small, and it is mostly prepared by artificial nuclear reaction. For example, using neutrons to bombard lithium-6 can produce 1H-tritium and helium-4. Due to its radioactivity and special physical properties, 1H-tritium is widely used in nuclear energy, radioactive tracer and other fields. In the field of nuclear energy, it is an important fuel for nuclear fusion reactions, promising to provide humans with clean and sustainable energy; in the field of radioactive tracer, it can be used to track the movement and changes of materials, and play a key role in biological, chemical and other scientific research fields.

As for the market price of "5-question-2-methyl-1H-imidazole", although it is not a common product in ancient times, it can also be obtained in the past.
The price of a merchant's goods often depends on supply and demand, workmanship, and luck. If there are many people who use this thing, there are many who want it, and there are few who produce it, the price will be high; on the contrary, if there are few users, and those who produce it are complex, the price will be low.
On its workmanship, the acquisition of raw materials, the preparation of equipment, and the work of craftsmen, all cost money and goods. If the raw materials are rare and rare, the equipment is exquisite and expensive, the craftsman's skills are exquisite, and the cost is huge, how can the price not be expensive?
Those who are lucky in time, the chaos of the world, the abundance of years, and the generosity of politics are all related to it. If the world governs years and abundance, and the government is wide and commercial, the goods will flow smoothly, and the price will be flat and stable; if the world is chaotic and the years are short, and the government is harsh and the business is stagnant, the stock will not be good, and the price may be expensive.
Although there is no detailed evidence to clarify the market price of "5-question-2-methyl-1H-imidazole", it may be speculated. It is only by examining the needs of various industries, observing the difficulties of its production system, and observing the changes of the times that its approximate price can be obtained. If you want an accurate number, when you visit the cities and ask the merchants, refer to the prices of the four sides, and weigh the similarities and differences, you can get its true price.