5-(Difluoromethoxy)-2-mercapto-1H-banzimidazole

5 - (diethylamino) - 2 - hydroxy - 1H - benzimidazole, this substance has a wide range of uses. In the field of medicine, it is often used as a key intermediate in drug synthesis. Due to its unique chemical structure, it can participate in the construction of many drug molecules and can be used to create drugs with specific pharmacological activities. Like some antibacterial and antiviral drugs, it may be used in the preparation process. Through its structural properties, it can help drugs achieve effective inhibition or killing of pathogens.
In the field of materials science, it also has important applications. It can be used as a functional material additive, integrated into specific material systems to improve material properties. For example, adding it to some polymer materials can enhance material stability, weather resistance, etc. This is because it can interact with polymer chains and change the internal structure and properties of materials.
In chemical research, it is a commonly used organic synthesis reagent. Chemists use it to carry out various organic reaction research and explore novel synthesis paths and methods. Because its structure contains a variety of active check points, it can trigger a variety of chemical reactions, providing a key tool and foundation for the development of organic synthesis chemistry. In short, 5 - (diethylamino) - 2 - hydroxy - 1H - benzimidazole plays an important role in many fields, promoting technological progress and development in related fields.

5 - (diethylamino) - 2 - hydroxy - 1H - indolo [2,3 - b] pyridine, which is an important member in the field of organic compounds. Its physical properties are unique and of great significance to chemical research and related applications.
Looking at its properties, it is mostly a crystalline solid under normal conditions, and its quality is stable, laying the foundation for subsequent research and application. Its melting point is within a specific range. This value fluctuates slightly due to the purity of the compound and the measurement environment, but the approximate range can be investigated, providing key parameters for practical operation.
In terms of solubility, it shows certain solubility characteristics in common organic solvents, such as ethanol and dichloromethane. In ethanol, the solubility increases gradually with the increase of temperature, and this phenomenon is related to the intermolecular force. In water, its solubility is limited, due to the large proportion of hydrophobic groups in the molecular structure, resulting in weak interaction with water molecules.
Then talking about density, the relative density has a specific value, reflecting the tightness of molecular stacking. This property is very important in chemical production involving material separation and mixing, which is related to process design and process optimization.
In addition, its volatility is extremely low, and it is difficult to have significant volatilization losses at room temperature and pressure, ensuring the stability of storage and use. This property allows the compound to be stored without special anti-volatilization measures, reducing storage costs and risks. The physical properties of 5- (diethylamino) -2-hydroxy-1H-indolo [2,3-b] pyridine provide a solid basis for its application in organic synthesis, drug development and other fields. According to these properties, researchers can rationally design reaction routes, optimize purification processes, and promote the development of related fields.

To prepare 5- (diethylamino) -2 -alkynyl-1H -indolo-pyrrole compounds, the following ancient methods can be used.
Take the appropriate starting material first. Depending on the structural characteristics of the compound, if the starting material is a compound containing indole parent nucleus and has a modifiable check point, it should be functionalized first. For example, taking an indole-containing structure with a halogen atom at a specific position as an example, a nucleophilic substitution reaction can be used to introduce a diethylamino group.
Place the indole raw material containing halogen atoms in a suitable reaction vessel, and add an appropriate amount of basic reagents, such as potassium carbonate, sodium carbonate, etc., to adjust the pH of the reaction system and promote the reaction. Then add diethylamine, dissolve it with an organic solvent, such as N, N-dimethylformamide (DMF), acetonitrile, etc., heat and stir to maintain an appropriate reaction temperature and time. During this process, the halogen atom undergoes nucleophilic substitution with diethylamine to form an indole intermediate containing diethylamino.
Then, the alkynyl group is introduced. Sonogashira coupling reaction can be used to react with the terminal alkynes in the presence of palladium catalysts and ligands. For example, palladium acetate is used as a catalyst, triphenylphosphine and other ligands are added, and an appropriate amount of basic reagents, such as diethylamine, triethylamine, etc., are added in organic solvents such as dichloromethane and toluene, heated and stirred, so that the reaction occurs smoothly, and the alkynyl group replaces the group in the corresponding position to obtain 5- (diethylamino) -2 -alkynyl-1H -indole intermediates.
Finally, a pyrrole ring is constructed. According to the specific reaction conditions and substrate characteristics, a suitable cyclization reaction can be used. If the substrate has suitable functional groups, such as carbonyl and amino groups, and the position is suitable, it can be cyclized within the molecule under acidic or basic conditions to form a 1H-indolopyrrole structure. For example, under acid catalysis, it promotes a series of reactions such as nucleophilic addition and dehydration in the molecule, and closes the loop to generate the target 5- (diethylamino) -2-alkynyl-1H-indolopyrrole compounds. After the reaction, pure products can be obtained through conventional operations such as separation and purification.

5 - (diethylamino) - 2 - hydroxy - 1H - benzimidazole, the price of this product in the market varies due to many reasons, and it is difficult to determine its fixed number.
However, looking at the general market conditions, the price range is about tens to hundreds of gold per catty. The price depends on many reasons.
First, the price of raw materials. If the price of diethylamine, o-phenylenediamine and other raw materials is high, the price of this product will also rise; if the price of raw materials falls, the price of this product will also fall.
Second, the production method is difficult. The production method is complicated, requires a lot of utensils and man-hours, and costs manpower and material resources, and the price must be high; if the production method is simple and the cost is saved, the price may be low.
Third, the supply and demand of the city. If there are many applicants, but there are few suppliers, the price will increase; if the supply exceeds the demand, and the goods are stocked in the city, the price will fall.
Fourth, the quality is good. Those who are of high quality are of good use in medicine and chemical industry, and the price must be higher than those who are of poor quality.
There are also decrees and regulations, transportation costs and other things, which can also make the price change. Therefore, if you want to know the exact price, you must carefully check the market conditions and consult various merchants before you can get a more accurate number.

The safety and toxicity of 5- (diethylamino) -2-benzyl-1H-indolopyridine are of paramount importance. The safety of this compound depends on the detailed investigation of its effects in various biological systems. According to the traditional herbal theory, the safety of drugs or compounds depends first on whether they are harmful to human organs and meridians. From a modern scientific perspective, it is necessary to consider its impact on the physiological functions of cells, tissues and even the whole organism.
View its toxicity, the appearance of toxicity is often related to the dose. Small doses may only cause mild discomfort, while large doses may cause serious damage. The mechanism of toxicity may be to interfere with the normal metabolism of cells, or affect nerve conduction, or destroy genetic material.
The safety and toxicity of Ximing 5- (diethylamino) -2 -benzyl-1H -indolopyridine must depend on many experiments. In vitro, cell experiments can be used to observe its effects on proliferation and apoptosis of different cell lines; in vivo, animal experiments should be used to explore its changes in organ function, behavior, etc.
It is also necessary to pay attention to its interaction with other substances in the body, or because it binds to certain proteins and affects the activity of enzymes, resulting in changes in safety and toxicity. In conclusion, in order to obtain a comprehensive picture of the safety and toxicity of this compound, it is necessary to consider the experimental data and make detailed judgments in a scientific and prudent manner, which should not be ignored.