5-Bromo-1H-benzoimidazole-2-carboxylic acid

5-Bromo-1H-benzimidazole-2-carboxylic acid, this is an organic compound, its physical properties are particularly important, related to its application in many fields.
First of all, its appearance, under room temperature and pressure, is mostly white to light yellow crystalline powder state. This color state characteristic is quite critical when it is initially identified and determined its purity. Looking at the uniformity of its color and the fineness of the powder, you can get a glimpse of its quality.
Second and melting point, the melting point of this compound is about 300 ° C. The melting point is an inherent property of the substance, just like a human fingerprint, which can be used for accurate identification. When it is heated, observe the critical temperature of its transformation from solid to liquid state. If it matches the melting point recorded in the literature, the purity and structure can be proved to be correct.
The other is solubility. In common organic solvents, such as dimethyl sulfoxide (DMSO), it exhibits good solubility and can be easily dissolved in it. However, in water, the solubility is poor. This difference in solubility is crucial in the process of synthesis, separation and purification. If you want to separate this compound from the reaction system, you can choose a suitable solvent according to its solubility in different solvents to achieve the purpose of effective separation.
In addition, its density is also an important physical property. Although the exact value varies depending on the measurement conditions, it is roughly within a certain range. The determination of density helps to accurately control its dosage in practical applications, and is of great significance in preparation, chemical reaction material ratio, etc.
The physical properties of 5-bromo-1H-benzimidazole-2-carboxylic acid, from appearance, melting point, solubility to density, each play a unique role, laying a solid foundation for its application in many fields such as organic synthesis and drug development.

5-Bromo-1H-benzimidazole-2-carboxylic acid, this is an organic compound with specific chemical properties. It is a white to light yellow solid, which is relatively stable at room temperature and pressure. In case of open flame, hot topic, or risk of combustion.
Its acidity is significant, because it contains carboxyl groups (-COOH), this functional group can release protons, which can be partially ionized in water and is acidic. It can neutralize with bases to form corresponding salts and water.
In the field of organic synthesis, this compound has a wide range of uses. Its benzimidazole structure endows it with unique reactivity and can be used as a key intermediate for the synthesis of many biologically active compounds, such as drugs and pesticides. Its bromine atom is also an important reaction check point, and other functional groups can be introduced through nucleophilic substitution reactions, etc., to expand the diversity of molecular structures and enrich its chemical properties and applications.
In terms of solubility, it is slightly soluble in water. Although there are polar carboxyl groups in the molecule, it can form hydrogen bonds with water, but the presence of benzimidazole ring and bromine atom increases the non-polarity of the molecule, resulting in limited water solubility. However, it is soluble in some organic solvents, such as dichloromethane, N, N-dimethylformamide, etc. This solubility characteristic facilitates the selection of suitable solvents in organic synthesis operations to achieve reaction progress and product separation.

5-Bromo-1H-benzimidazole-2-carboxylic acid, this substance has a wide range of uses. In the field of medicine, it is often a key intermediate for the synthesis of many drugs. The structure of Gein-benzimidazole has unique biological activity. After introducing bromine atoms and carboxyl groups, it can optimize drug activity, lipophilicity and target binding ability. On this basis, it can create various specific drugs such as antibacterial, antiviral, and anti-tumor, bringing good news to patients.
In the field of materials science, it also has important uses. With its own structural characteristics, it can participate in the preparation of polymer materials with unique functions. For example, polymerization with other monomers through specific reactions can endow materials with special properties such as fluorescence, adsorption, etc., which can play a role in sensors, separation materials, etc.
In the field of organic synthesis, 5-bromo-1H-benzimidazole-2-carboxylic acid is an extremely important starting material. With the help of its bromine atom and carboxyl group activity, many complex organic compounds can be derived through various chemical reactions, contributing to the development of organic synthetic chemistry, promoting the field to continue to expand and explore more unknown possibilities.

The synthesis methods of 5-bromo-1H-benzimidazole-2-carboxylic acid have different paths. One method is to take phthalamine and diethyl bromomalonate as raw materials, and heat them in a suitable organic solvent, such as ethanol, with an appropriate amount of bases, such as potassium carbonate as a catalyst. In this process, the amino group of phthalamine interacts with the ester group of diethyl bromomalonate, and undergoes a series of reactions such as nucleophilic substitution to form intermediate products. Subsequently, this intermediate product is hydrolyzed under acidic conditions, such as in a hydrochloric acid solution, heated to reflux, the ester group is hydrolyzed to a carboxyl group, and the benzimidazole ring is formed at the same time. Finally, 5-bromo-1H-benzimidazole-2-carboxylic acid is obtained.
Another method is to use 4-bromo-1,2-diaminobenzene and oxalic acid as starting materials. Mix the two in a high-boiling organic solvent, such as N, N-dimethylformamide (DMF), add an appropriate amount of dehydrating agent, such as acetic anhydride, and heat to initiate the reaction. The amino group of 4-bromo-1,2-diaminobenzene interacts with oxalic acid, first dehydrated and condensed, and then cyclized within the molecule to construct the benzimidazole structure. At the same time, a carboxyl group is introduced to obtain the target product 5-bromo-1H-benzimidazole-2-carboxylic acid.
Furthermore, 2-nitro-4-bromoaniline can be used as the starting material and first underwent a reduction reaction. For example, in a system composed of iron powder and hydrochloric acid, the nitro group is reduced to an amino group to obtain 2-amino-4-bromoaniline. After that, it reacts with ethyl dichloroacetate in an alkaline environment, such as sodium hydroxide, in an ethanol solvent to form an intermediate product. Finally, the intermediate product can be hydrolyzed, cyclized and other steps to obtain 5-bromo-1H-benzimidazole-2-carboxylic acid. These many methods have their own advantages and disadvantages, and need to be selected according to the actual situation, such as the difficulty of obtaining raw materials, the control of reaction conditions, and the requirements of product purity.

5-Bromo-1H-benzimidazole-2-carboxylic acid is in the market, and its price range is difficult to determine. Looking at the example of "Tiangong Kaiwu", the price of things in the past often varies with time, place, quality and supply and demand. If the price of this compound is sought in the market, its price must also change according to these factors.
If its quality is high and pure, and when there are many in need and few in supply, the price must be high. On the contrary, if the quality is ordinary, the market supply is abundant, and there are few in demand, the price should be low.
If you order from a nearby pharmacy or chemical firm, the price may vary depending on the size of the firm and the source of the goods. If the purchase quantity is small, the price per gram may be between tens and hundreds of dollars; if it is purchased in bulk, the price per gram may be slightly reduced due to the large quantity. However, these are all speculative numbers, and the actual price must be obtained from the vendors.