5-Bromo-1-methyl-1H-imidazole

5 - Bromo - 1 - methyl - 1H - imidazole is a kind of organic compound. Its main use involves the field of organic synthesis. In organic synthesis, it is often used as a key intermediate.
The imidazole ring connected to bromine atom and nitrogen methyl group has special reactivity due to its unique structure. This compound can be replaced by other nucleophilic groups through various chemical reactions, such as nucleophilic substitution reaction, bromine atom is active, and it is easy to be replaced by other nucleophilic groups. This can introduce various functional groups, expand the complexity of molecular structure, and lay the foundation for the construction of more delicate organic molecules. < Br >
In the field of medicinal chemistry, this can be used as a starting material to synthesize compounds with specific pharmacological activities through a series of reactions. Some imidazole derivatives have emerged in the pharmacological research of antibacterial and antiviral, and 5-Bromo-1-methyl-1H-imidazole may be used as an important starting material, paving the way for the creation of new drugs.
In the field of materials science, it also has potential uses. Through chemical modification, it may be able to prepare materials with special properties, such as functional polymer materials. Its imidazole ring structure may endow materials with specific chemical activities, coordination capabilities, etc., thus expanding the application range of materials, such as sensors, catalyst carriers and other fields.
Overall, although 5-Bromo-1-methyl-1H-imidazole is a small organic molecule, it has shown important application value in many fields such as organic synthesis, drug research and development, and materials science, opening up many possibilities for chemical research and industrial production.

5 - Bromo - 1 - methyl - 1H - imidazole is an organic compound. Its physical properties are very important and are key to many chemical applications.
This compound is mostly solid at room temperature. Viewed, the color is either white or nearly white, and its powder or crystal form is fine. Its melting point is about 130 - 134 ° C. At this temperature, the substance gradually melts from solid to liquid, which is of great significance in the experimental operation of separation and purification.
Furthermore, 5 - Bromo - 1 - methyl - 1H - imidazole has limited solubility in water, but it can be soluble in organic solvents such as dichloromethane and ethanol. In dichloromethane, it dissolves rapidly and uniformly, which makes dichloromethane often the choice of extraction or reaction solvent. In ethanol, although the solubility is also available, the dissolution situation is slightly complicated due to the mutual solubility of ethanol and water.
Its density cannot be ignored, about 1.65 g/cm ³. This value determines its position and distribution in the solution system. It also affects the stratification of the mixed solution and the precipitation or floating state of the substance in the reaction vessel.
In addition, the stability of the compound is acceptable under normal conditions. However, when it encounters strong oxidizing agents, strong acids, and strong bases, it is easy to chemically react, and the structure may be damaged. This is also something that needs to be carefully considered when storing and using.

The synthesis method of 5-bromo-1-methyl-1H-imidazole, although the ancient book "Tiangongkai" does not contain this specific synthesis method, the current chemical synthesis method can be explored.
First, 1-methyl imidazole is used as the starting material, and bromine atoms are introduced into the appropriate reaction system. Brominating reagents, such as N-bromosuccinimide (NBS), are often used in organic synthesis for bromination reactions under mild conditions. In organic solvents such as carbon tetrachloride, benzoyl peroxide (BPO) is used as the initiator. Under heating or lighting conditions, NBS can bromide specific positions of 1-methylimidazole to obtain 5-bromo-1-methyl-1H-imidazole. During the reaction process, attention should be paid to controlling the reaction temperature, reagent dosage and reaction time to prevent side reactions, such as excessive bromination to form polybrominated products.
Second, the methylation reaction can also be carried out from imidazole first. Methylation reagents such as iodomethane can be reacted in a suitable solvent in the presence of bases such as potassium carbonate to generate 1-methylimidazole. After that, the target product can also be obtained by brominating 1-methylimidazole with brominating reagents such as NBS as described above. In this route, the methylation reaction needs to pay attention to the intensity and amount of base to prevent the imidazole ring from being overly affected, and the bromination step also needs to be carefully regulated.
Third, the synthesis path catalyzed by other specific catalysts. For example, some transition metal catalysts can selectively promote the substitution of bromine atoms at specific positions of the imidazole ring. By rationally designing the reaction conditions, such as selecting suitable ligands to form a catalyst system with transition metals, the selectivity and yield of the reaction can be improved, and unnecessary side reactions can be reduced. Although this method has high technical requirements, it has great potential for the synthesis of high purity 5-bromo-1-methyl-1H-imidazole.

The price range of 5-bromo-1-methyl-1H-imidazole in the market is difficult to determine. The price of 5-bromo-1-methyl-1H-imidazole often varies due to many factors, such as quality, supply and demand, preparation method, purchase quantity, and even seasonal changes.
If it is based on quality, the price of high purity will be higher than that of low purity. High purity 5-bromo-1-methyl-1H-imidazole has few impurities, and it is easier to achieve accurate results when applied in scientific research, medicine and other fields, so the price is high.
The trend of supply and demand is also the main reason. If there are many people in the market, but there are few supply, the price will rise; conversely, if the supply exceeds the demand, the price may drop.
The preparation method is related to the cost and also affects the price. Complex and expensive preparation method, the price of 5-bromo-1-methyl-1H-imidazole produced is also high; simple and low cost, the price or close to the people.
The amount of purchase is small, which also affects the price. A large number of buyers often get preferential prices, so they sell more with small profits; if they buy in small quantities, the price may be slightly higher.
Seasonal changes affect the supply of raw materials, production efficiency, etc., and then affect the price.
However, if you want to know the exact price range, you can go to chemical trading platforms, such as Gade Chemical Network, Mobell, etc.; or consult chemical raw material suppliers, who can provide a close price range according to the current situation.

5-Bromo-1-methyl-1H-imidazole is also an organic compound. Its storage conditions are crucial and related to the stability and quality of this compound.
This compound should be stored in a cool place, because high temperature can easily cause its chemical reaction and damage its chemical structure and properties. The temperature should be controlled between about 2-8 ° C. Such a low temperature environment can reduce the activity of its molecules and maintain the stability of its chemical properties.
And it must be placed in a dry place to avoid moisture. Water is easy to react with many organic compounds. If 5-bromo-1-methyl-1H-imidazole encounters water vapor, or causes adverse reactions such as hydrolysis, its purity and quality will be damaged. Therefore, the storage place should have good moisture-proof facilities, such as placing desiccant on the side of the storage container to absorb possible water vapor.
Furthermore, it should be stored in a sealed container. In the air, there are gases such as oxygen and carbon dioxide, or they work with the compound. The sealed device can prevent the intrusion of air and prevent it from oxidizing or reacting with other gases. After taking it, it must also be sealed in time to avoid long-term exposure to air.
In addition, the storage place should be away from fire and heat sources, because it may be flammable, in case of open flame, hot topic, fear of danger, fire or even explosion.
The storage of 5-bromo-1-methyl-1H-imidazole needs to be cool, dry, sealed and away from the fire source heat source, so as to ensure its quality and safety for subsequent experiments or production.