5-Amino-1-(N-methylcarbamoyl)imidazole-4-carboxamide

5-Amino-1- (N-methylcarbamoyl) pyrazole-4-formamide, its derivative 4-formamidopyridine has important uses in many fields.
In the field of medicine, 4-formamidopyridine is a key intermediate for synthesizing a variety of drugs. For example, some anti-cancer drugs, with the unique chemical structure of 4-formamidopyridine, can precisely act on specific targets of cancer cells and inhibit the growth and spread of cancer cells. This structural property allows them to interact with key biomolecules in cancer cells, block cancer cell signaling pathways, or interfere with cancer cell metabolic processes, thereby achieving anti-cancer effects.
In the field of pesticides, 4-formamidopyridine plays an indispensable role. The insecticides and fungicides made from this raw material have significant effects on the prevention and control of crop diseases and pests. With its special chemical activity, it can effectively kill pests, inhibit the growth of pathogens, and has high safety for crops. It can effectively ensure crop yield and quality, and help agricultural harvests.
In the field of materials science, 4-formamidopyridine can participate in the synthesis of functional materials. With its chemical activity, it can be combined with other organic or inorganic materials to give materials special properties. For example, the preparation of materials with specific optical, electrical or thermal properties is widely used in electronic devices, optical instruments and other fields. With its unique chemical structure and activity, 4-formamidopyridine has shown important value in the fields of medicine, pesticides, and materials science, and has made significant contributions to the development of various fields.

Ethyl ester of 5-amino-1- (N-methylcarbamoyl) pyrazole-4-formamide is a unique compound in the field of organic chemistry. The physical properties of ethyl esters have the following characteristics.
Ethyl esters have a special smell. This ethyl ester of 5-amino-1- (N-methylcarbamoyl) pyrazole-4-formamide often emits a relatively light and unique fragrance, but its taste is not pungent and strong, but a relatively soft and unique taste that can be perceived by the sense of smell.
Looking at its physical state, under normal temperature and pressure, this ethyl ester usually appears as a liquid state. The appearance of its liquid is clear and transparent, without obvious turbidity or impurities, just like clear water, and it can show a crystal clear texture under light.
In terms of boiling point, this ethyl ester has a specific boiling point value. Due to the influence of intermolecular forces and other factors, its boiling point is within a certain range. Roughly speaking, its boiling point is sufficient to make it change from liquid to gaseous under ordinary heating conditions, but the specific boiling point needs to be determined by accurate experiments. Generally speaking, its boiling point can ensure that in conventional laboratory or industrial operating environments, its phase state can be changed by reasonable heating means to facilitate separation, purification and other operations.
Furthermore, its melting point is also one of the important physical properties. The melting point determines the critical temperature at which the substance changes from solid to liquid. The melting point of this ethyl ester of 5-amino-1- (N-methylcarbamoyl methyl) pyrazole-4-formamide is such that it maintains a liquid state at room temperature, and when the temperature is reduced to a certain extent, it will gradually solidify into a solid state. Precisely knowing its melting point is of great significance for storage, transportation, and the control of related chemical reaction conditions.
In addition, the ethyl ester also has characteristics in terms of solubility. In organic solvents, such as ethanol, acetone, and other common organic solvents, it exhibits good solubility and can be miscible with these solvents in a certain proportion to form a uniform solution system. This property facilitates the preparation of organic synthesis reactions and related preparations, enabling the reaction to be carried out more efficiently in a homogeneous system. However, its solubility in water is relatively limited, due to the existence of hydrophobic parts in its molecular structure, which makes it insoluble in water. Only under specific conditions, such as by means of surfactants, can its dispersion in water be increased.

5-Hydroxy-1- (N-methylhydroxyformamido) pyrimidine-4-formamide is a complex organic compound. Its chemical properties are unique and related to many chemical reactions and characteristics. The detailed analysis is as follows:
In this compound, the hydroxyl group (-OH) is active and reactive. Hydroxy hydrogen atoms are easily dissociated and have a certain acidity, which can participate in acid-base reactions. When encountering strong bases, hydroxyl hydrogen will be taken away by the base to form corresponding salts. At the same time, because the oxygen atom is rich in lone pair electrons, the hydroxyl group can interact with other compounds containing active hydrogen atoms through hydrogen bonds, which affects the solubility and molecular aggregation state of the substance.
N -methylhydroxyformamide group, the amide bond (-CONH -) is stable, but under the condition of strong acid or strong base and heating, hydrolysis reaction can occur. When catalyzed by acid, water attacks carbonyl carbons, and goes through a series of intermediates to form carboxylic acids and amines; when catalyzed by base, OH attacks carbonyl carbons, and finally produces carboxylic salts and amines. And methyl (-CH 🥰) is the power supply group, which will change the electron cloud density of the atoms connected to it and affect the reactivity of the compound.
The pyrimidine ring system has aromatic properties, which are determined by its conjugated π electron system. This aromaticity endows the pyrimidine ring with stability, making it less prone to addition reactions, and more prone to electrophilic substitution reactions. Electrophilic reagents will attack the higher electron cloud density of the pyrimidine ring and form substitution products.
4-formamide groups also have amide bonds, which can participate in condensation reactions in addition to hydrolysis reactions. For example, react with amines under appropriate conditions to generate new nitrogen-containing compounds.
5-hydroxy-1 - (N-methylhydroxyformamido) pyrimidine-4-formamide exhibits diverse chemical properties due to the interaction of various functional groups. These properties make it significant in the fields of organic synthesis and medicinal chemistry, and lay the foundation for the creation of new compounds and drug development.

The synthesis of 5-hydroxy-1- (N-methylhydroxymethylbenzyl) piperidine-4-methylpyridine involves several methods.
First, it can be started from the basic organic compound. First, appropriate phenols are taken to react with halogenated alkanes in a basic environment to obtain corresponding ethers. Among them, the hydroxyl group of phenol can be the active check point of the reaction, and the halogenated alkanes provide alkyl groups. The base can help the phenolic hydroxyl deprotonation, enhance its nucleophilicity, and then promote the reaction. The obtained ethers are further modified. Or introduce nitrogen-containing functional groups, such as by reacting with amine compounds, using nucleophilic substitution and other mechanisms to integrate nitrogen atoms into the molecular structure. This process requires attention to the regulation of reaction conditions, such as temperature, solvent selection, etc., different conditions or differences in reaction selectivity and yield.
Second, it is also a good strategy to use pyridine derivatives as starting materials. Pyridine rings have certain stability and reactivity. The desired substituent can be introduced through electrophilic substitution reaction at a specific position of the pyridine ring. For example, by taking advantage of the distribution characteristics of electron cloud density on the pyridine ring, a suitable electrophilic reagent is selected, and under appropriate conditions, the electrophilic reagent attacks the target check point on the pyridine ring. After that, the side chain of the pyridine ring is constructed. The side chain structure of 5-hydroxy-1- (N-methylhydroxymethylbenzyl) piperidine-4-methylpyridine is gradually constructed by reacting with the pyridine derivative with suitable reagents. In this path, the localization effect of the pyridine ring is the key, and the reaction conditions need to be accurately grasped to achieve the expected substitution position and product structure.
Third, the cyclization reaction strategy can also be considered. Select chain compounds with suitable functional groups and achieve cyclization through intramolecular reactions. For example, chain-like compounds containing functional groups such as hydroxyl groups, halogen atoms, and nitrogen atoms can undergo cyclization reactions such as nucleophilic substitution in molecules in the presence of suitable catalysts. First form the prototype of piperidine ring or pyridine ring, and then further modify and adjust the substituents on the ring. This process requires high structural design of the reaction substrate, and it is necessary to ensure the relative position and activity of each functional group, so as to promote the cyclization reaction to occur smoothly, and finally lead to the formation of the target product. In short, the synthesis of this compound requires comprehensive consideration of the selection of starting materials, the optimization of reaction conditions, and the connection between each step, in order to effectively achieve.

Wen Jun inquired about the price range of 5-amino-1- (N-methylaminomethyl) pyrazole-4-formamide in the market. However, this product is not an ordinary and easy-to-use product, and it is useful in specific fields such as chemical industry and pharmaceutical research and development. Therefore, its price varies with changes in quality, quantity, source and market demand.
If it is normal, if it is a laboratory-grade pure product, its quality is high and the quantity is rare, and the price per gram may be between tens and hundreds of gold. Because of its preparation process or fine synthesis, the raw materials may be rare and rare, so the price is high.
If it is an industrial grade, considering the regulations of mass production and cost control, the price per ton may be tens of thousands to hundreds of thousands of gold. This is due to the large demand for industrial use, the expansion of production scale, and the cost is slightly reduced. However, the process control and Quality Standards are still strict, so the price is not cheap.
And its price fluctuates with the supply and demand of the market. If the demand is prosperous at a time and the supply is not enough, the price will rise; on the contrary, if the supply exceeds the demand, the price may be depressed. And the price is also related to the distance of the place of origin, transportation costs, tax regulations and other factors. In order to know the exact price, it is necessary to check the market situation carefully and consult the supplier to obtain a more accurate number.