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What is the chemical structure of 5-Amino-1-beta-ribofuranosyl-imidazole-4-carboxamide?
5 - Amino - 1 - β - ribo fura nosyl - imidazole - 4 - carboxamide, the Chinese name is often 5 - amino - 1 - β - furan ribosyl - imidazole - 4 - formamide, its chemical structure consists of three parts.
The first is the imidazole ring, this five-membered heterocycle contains two nitrogen atoms, has aromatic properties, and is a key structural unit in many bioactive molecules. In this compound, it is an important component of the core skeleton, giving it specific chemical and biological properties. < Br >
is a β-furan ribosyl group, which is connected to the nitrogen atom of the imidazole ring through glycosidic bonds. Furan ribosyl is a five-carbon sugar, which is connected in the β configuration. This glycosyl part not only adds hydrophilicity to the molecule, but also plays a key role in the interaction with many enzymes and receptors in vivo, affecting the metabolism and activity of compounds. The end of
is the 5-position amino group and the 4-position formamide group. Amino groups are basic and can participate in the formation of hydrogen bonds and acid-base reactions, changing the electron cloud distribution and chemical activity of molecules; formamide groups contain carbonyl groups and amino groups, which can also participate in hydrogen bonds and have a great impact on the stability and biological activity of molecules. These groups work together to make 5 - Amino - 1 - β - ribo fura nosyl - imidazole - 4 - carboxamide have unique physical, chemical and biological properties, and have important research value in the fields of medicine and biochemistry.
What are the main uses of 5-Amino-1-beta-ribofuranosyl-imidazole-4-carboxamide?
5 - Amino - 1 - β - ribo fura nosyl - imidazole - 4 - carboxamide, the Chinese name is often 5 - amino - 1 - β - ribofuran imidazole - 4 - formamide, referred to as AICAR. This substance has a wide range of uses and has its own reasons. The details are as follows:
In the field of medicine, its importance is significant. It can be used as a key intermediate for drug development. Due to its unique structure, AICAR can interact with many biological macromolecules in the body. For example, it can regulate intracellular signaling pathways through specific mechanisms, which is of great therapeutic significance for certain diseases. Like in diabetes research, AICAR can simulate the impact of exercise on the body, activate relevant metabolic pathways, regulate blood sugar levels, and provide new ideas for the creation of diabetes treatment drugs. And in the field of anti-cancer drug research, AICAR has a regulatory effect on the proliferation and apoptosis of cancer cells, opening up new directions for the development of anti-cancer drugs.
In the field of biochemical research, AICAR is a powerful tool. Researchers use it to explore basic biological processes such as cell metabolism and signal transduction. Because it can affect the activity of enzymes related to energy metabolism in cells, such as activating adenosine monophosphate-activated protein kinase (AMPK). By observing the physiological changes of cells after the action of AICAR, we can deeply understand the specific mechanism of AMPK in the regulation of cellular energy balance, as well as the coping strategies of cells in different metabolic states, and help the continuous improvement of biological theory.
In the field of agriculture, AICAR is also useful. When plants face various adversity, AICAR can participate in the regulation of plant physiological response mechanisms. For example, under stress conditions such as drought and salinity, appropriate application of AICAR can regulate the osmotic balance in plant cells, enhance plant antioxidant capacity, and improve plant tolerance to adversity, thereby improving crop yield and quality, which is of great significance to agricultural production.
What is 5-Amino-1-beta-ribofuranosyl-imidazole-4-carboxamide synthesis method?
5-Amino-1 - β - nitrofuran-imidazole-4-formamide is an important compound in the field of biochemistry, and its synthesis method is quite complicated.
In the past, the initial step of synthesis was often based on suitable nitrofuran derivatives as starting materials. First, the nitrofuran is functionally modified to have an active check point for reacting with imidazole derivatives. This process requires fine regulation of reaction conditions, such as temperature, pH and reaction duration, to ensure that the reaction proceeds in the desired direction.
When the furan ribose is properly modified, it is combined with the imidazole compound containing a specific substituent. The two are condensed to form a connection between the imidazole and the furan ribose. This step is the key to the synthesis, and a suitable catalyst is required to improve the reaction efficiency and selectivity.
During the reaction process, the product is often accompanied by impurities, which must be separated and purified. Commonly used methods, such as column chromatography, recrystallization, etc., to remove voids and store cyanine, to obtain pure 5-amino-1 - β - furan-imidazole-4-formamide.
In addition, there are also those who optimize the synthesis path through multi-step reactions. Or pre-modify the imidazole ring first, introduce the embryonic form of amino and carboxyamide groups, and then associate it with furan ribose to improve the structure through subsequent reactions.
During the synthesis, many details need to be paid attention to. The purity of the raw materials and the cleanliness of the reaction equipment are all related to the success or failure of the synthesis. Only by carefully controlling all links can we synthesize this compound efficiently and with high quality.
What are the physical properties of 5-Amino-1-beta-ribofuranosyl-imidazole-4-carboxamide?
5 - Amino - 1 - β - ribo fura nosyl - imidazole - 4 - carboxamide, Chinese name is often 5 - amino - 1 - β - nitrofuran imidazole - 4 - formamide, AICA - riboside, this material is specific to physical properties, and is widely used in the field of biochemistry.
Its outer appearance is often white to white crystalline powder, and it is difficult to produce. Under the normal conditions of the room, the quality of this material is still good, but it is easy to biochemically change when encountering high-end components such as high-quality, acid, and acid.
In terms of solubility, it has a certain solubility in water, and this property is due to the close phase of the chemical groups contained in its molecules. The chemical groups interact with water molecules to promote their partial solubility in water, so the solubility is not limited. In addition, in soluble substances such as ethanol and acetone, the solubility of the phase is low, due to the poor compatibility of the molecular integrity and solubility.
This material has a melting value, and its melting value is generally limited to a specific degree of solubility. This property can be used to determine the degree of solubility. If the degree of material is high, the melting temperature is high and the melting temperature is narrow; if it is high, the melting temperature is often offset and the melting temperature is low.
Its density is also an important physical property. The specific density reflects the density of its molecular stack, its crystallization and molecular force phase. This density value is important for the operation of material quantity and mixing in the process of chemical engineering and chemical processing.
Therefore, 5 - Amino - 1 - β - ribo fura nosyl - imidazole - 4 - carboxamide. It lays the foundation for its use in multiple fields such as biological research and chemical research. Researchers can make rational use of its physical properties and prepare materials to fully improve the efficacy of this material.
What is the price range of 5-Amino-1-beta-ribofuranosyl-imidazole-4-carboxamide in the market?
5-Amino-1 - β - furanosyl-imidazole-4-formamide, the price of this product in the market is difficult to determine. The change in its price depends on many reasons.
The first one is the purity of this product. If its quality is pure, it is almost flawless, and the price must be high; if it contains impurities and the purity is not high, the price may drop. The beautiful jade of ancient times, the pure one is expensive, and the miscellaneous one is cheap.
Both are related to production and demand. If there is a lot of production, but there are few people seeking it, the price will easily fall; if there is a small amount of production, but there are many people who need it, such as rare treasures, the price will rise. In the past, a rare substance was produced less and there were many people seeking it, so the price soared.
Furthermore, the preparation method also affects its price. If the method is simple and low cost, the price may be close to the people; if the method is complicated and time-consuming, the price will be difficult to drop.
According to what I have heard, the price may be between tens of yuan and hundreds of yuan per gram. However, this is only an approximate number, and the actual price often varies according to time, place and market conditions. If you want to know the exact price, you should consult pharmaceutical merchants, chemical merchants, or inspect it in detail in the market to obtain its true price.