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What is the chemical structure of 5- (2-ethyl-2, 3-dihydro-1H-inden-2-yl) -1H-imidazole hydrochloride (1:1)?
This is the chemical structure analysis of 5- (2-ethyl-2,3-dihydro-1H-indene-2-yl) -1H-imidazole, hydrochloride (1:1). It is connected by an imidazole ring to a specific substituted indene group and binds to a molecule of hydrochloric acid.
The first imidazole ring, which is a five-membered heterocycle containing two nitrogen atoms, is aromatic. In the 1H-imidazole structure, the hydrogen atom at position 1 is substituted. The substituent is 2-ethyl-2,3-dihydro-1H-indene-2-yl. The indene structure is originally a benzene ring conjugated to a five-membered ring, 2,3-dihydro indicates that one of the two double bonds in the five-membered ring is hydrogenated, and 2-ethyl is introduced into the ethyl group at position 2 of the indenyl five-membered ring.
Furthermore, the compound forms a 1:1 salt with hydrochloric acid, which means that the lone pair electron of the nitrogen atom on the imidazole ring binds to the hydrogen ion in hydrochloric acid to form an ionic bond, forming this hydrochloride salt. The characteristics of this chemical structure give it specific physical and chemical properties, which may have important applications in many chemical and biological fields.
What are the physical properties of 5- (2-ethyl-2, 3-dihydro-1H-inden-2-yl) -1H-imidazole hydrochloride (1:1)?
5- (2-ethyl-2,3-dihydro-1H-indene-2-yl) -1H-imidazole hydrochloride (1:1) is an organic compound whose physical properties are particularly important and have a great impact on chemical research and applications.
The determination of the melting point of this compound at room temperature or in solid form is of great significance for identification and purity evaluation. However, the exact melting point value can only be determined by experiments, and it is affected by many factors, such as the purity of the compound and the crystalline morphology.
To observe its solubility, in common organic solvents, or in different dissolution situations. In polar organic solvents, such as methanol and ethanol, or with a certain solubility. Because its molecular structure contains polar groups, it can interact with polar solvents, such as hydrogen bonding, dipole-dipole interaction, etc., so it promotes dissolution. In non-polar organic solvents, such as n-hexane and toluene, the solubility may be very low, because its non-polar structure interacts weakly with non-polar solvents.
The density of this compound is also a key physical property. Although the exact density data depends on experimental measurements, it can be inferred according to its molecular structure and the properties of similar compounds. Generally speaking, its density may be similar to that of common organic solids, but it will eventually vary due to the different types, numbers and arrangements of atoms in the molecule.
In addition, the appearance of this compound may be white to light yellow powder or crystalline solid, which can be used for reference in preliminary identification and quality judgment.
When studying and applying this compound, the above physical properties must be carefully considered, as it has a profound impact on its synthesis, separation, purification and application efficiency.
What are the main uses of 5- (2-ethyl-2, 3-dihydro-1H-inden-2-yl) -1H-imidazole hydrochloride (1:1)?
5- (2-ethyl-2,3-dihydro-1H-indene-2-yl) -1H-imidazole hydrochloride (1:1) is an organic compound. It has a wide range of uses and is often used as a key intermediate for active pharmaceutical ingredients in the field of medicine. Due to its unique chemical structure, it can be combined with other substances through specific chemical reactions to prepare drugs with specific pharmacological activities.
In the process of drug development, scientists use such compounds to explore and develop new drugs for the treatment of various diseases. Or because it can precisely act on specific biological targets in the human body, regulate physiological functions, and achieve the purpose of treating diseases.
Furthermore, in the field of organic synthesis chemistry, this compound is also an important raw material. Chemists can build more complex and diverse organic molecular structures based on their structural properties through clever chemical synthesis strategies, expand the variety of organic compounds, and provide new materials and raw materials for materials science, chemical industry and other fields.
For example, in the synthesis of new polymer materials, this compound participates in reactions that may endow materials with unique physical and chemical properties, such as improving material stability and solubility, and play an important role in many industrial and scientific research fields.
What are the synthesis methods of 5- (2-ethyl-2, 3-dihydro-1H-inden-2-yl) -1H-imidazole hydrochloride (1:1)?
The method of synthesizing 5- (2-ethyl-2,3-dihydro-1H-indene-2-yl) -1H-imidazole hydrochloride (1:1) is very particular. First, a carbonyl-containing group can be introduced by a suitable starting material, such as an aromatic hydrocarbon with a specific substituent, through Friedel-Crafts acylation reaction. After that, the carbonyl group is converted into an alcohol hydroxyl group by reduction means, and then the indene ring structure is constructed through a series of steps such as dehydration and cyclization.
As for the imidazole part, a suitable nitrogen-containing raw material, such as a mixture of glyoxal, formaldehyde and ammonia, can be selected to react under specific conditions to form an imidazole matrix. Subsequently, the compound containing the indene ring structure and the imidazole matrix are condensed under suitable reaction conditions, such as the presence of suitable solvents, temperatures and catalysts, to form the backbone of the target compound.
Finally, by reacting with hydrogen chloride gas or hydrochloric acid solution, a salt is formed to obtain 5- (2-ethyl-2,3-dihydro-1H-indene-2-yl) -1H-imidazole hydrochloride (1:1). During this period, it is crucial to control the reaction conditions, such as the need for precise regulation of temperature, too high or too low may affect the selectivity and yield of the reaction; the choice of solvent is also related to the reaction process, which needs to be able to dissolve the reactants well and have no adverse effects on the reaction; the amount and type of catalyst will also affect the reaction rate and product purity. In this way, it is expected to synthesize this compound efficiently and with high purity.
5- (2-ethyl-2, 3-dihydro-1H-inden-2-yl) -1H-imidazole hydrochloride (1:1) What are the precautions during storage and use?
5- (2-ethyl-2,3-dihydro-1H-indene-2-yl) -1H-imidazole hydrochloride (1:1) is a chemical substance. During storage and use, many matters need to be paid attention to.
First, when storing, be sure to store in a dry place. Because of its hygroscopicity, if the environment is humid, it is easy to cause the substance to be damp and deteriorate, affecting its chemical properties and purity. For example, during the rainy season in the south, the air humidity is high, and it should be properly stored. A sealed container can be used and a desiccant can be added.
Second, temperature is also critical. Store in a cool environment to avoid high temperatures. Under high temperature, the substance may undergo chemical reactions such as decomposition and polymerization. If stored in a warehouse with too high temperature, its quality may decrease. Generally speaking, the storage temperature should be controlled within a specific range, such as 2-8 ° C.
Third, when using, safety protection is indispensable. Wear appropriate protective equipment, such as gloves, goggles, etc. Because it may cause irritation to the skin, eyes, etc., if inadvertently exposed, rinse with plenty of water immediately and seek medical attention as appropriate.
Fourth, the retrieval process should ensure accurate operation. According to experimental or production needs, measure accurately to prevent dosage deviations from affecting experimental results or product quality. And seal the remaining substances in time after taking them out to prevent them from changing in contact with the air for a long time.
Fifth, when mixing with other substances, its chemical compatibility should be clarified in advance. If you mix with incompatible substances at will, or cause a violent reaction, it will endanger safety. Only with caution and attention to details can we ensure the safety and effectiveness of this chemical substance during storage and use.