5-(1H-pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol

5- (1H-pyrazole-1-yl) -1H-benzo [d] imidazole-2-carboxylic acid, this compound has important applications in the fields of medicine, pesticides and materials science.
In the field of medicine, it can be used as a pharmaceutical active ingredient. The structure of pyrazole and benzimidazole endows the compound with unique biological activities and pharmacological properties, and shows potential therapeutic value for a variety of diseases. For example, for some cancers, after design and modification, the compound may precisely act on specific targets of cancer cells, block cancer cell growth and proliferation signaling pathways, and achieve anti-cancer purposes; for inflammation-related diseases, it may regulate the release and signaling of inflammatory mediators in the body, and exert anti-inflammatory effects.
In the field of pesticides, it can be used as a key intermediate in the creation of pesticides. By introducing different substituents, changing the physical and chemical properties and biological activities of compounds, high-efficiency, low-toxicity and environmentally friendly pesticide varieties have been developed. For example, it has high-efficiency contact, stomach toxicity or internal absorption activities against pests, can effectively control a variety of crop pests, ensure crop yield and quality, and has little impact on the environment, which is in line with the development needs of modern green agriculture.
In the field of materials science, 5- (1H-pyrazole-1-yl) -1H-benzo [d] imidazole-2-carboxylic acids can be used to prepare functional materials due to their special structures and properties. Metal-organic framework materials (MOFs) with specific structures and functions are constructed as ligands to coordinate with metal ions, which have broad application prospects in gas adsorption and separation, catalysis, and fluorescence sensing.

To prepare 5- (1H-pyrazole-1-yl) -1H-benzo [d] imidazole-2-carboxylic acid, there are three methods.
One is the method of condensation cyclization. First, take the compound containing pyrazolyl group and the precursor containing benzimidazole structure, in a suitable reaction medium, such as an organic solvent, with a specific condensation agent, such as condensation reagent A, under the condition of heating and stirring, make the two condensation reaction, and then cyclize to obtain the target product. In this process, the reaction temperature needs to be precisely controlled in a certain range, such as 100 to 120 degrees Celsius, the reaction time is also exquisite, about 6 to 8 hours (hours), and the proportion of the reactants is also strictly required to make the yield considerable.
The second is the way of substitution reaction. With 1H-benzo [d] imidazole-2-carboxylic acid as the substrate, it is first activated to make its specific position more reactive. After that, the activated substance is combined with 1H-pyrazole in an alkaline environment, with base B as the acid binding agent, at a certain temperature, such as 60 to 80 degrees Celsius, the reaction is 3 to 5 hours (hours), and the pyrazolyl is substituted to the corresponding position of benzimidazole through a substitution reaction to obtain the product.
The third is a multi-step synthesis method. First, the basic structures of pyrazole and benzimidazole are constructed through several steps of reaction, and then the two are connected by a connection reaction. For example, raw material A is first reacted with 1 to obtain a pyrazole-containing fragment, raw material B is reacted with 2 to obtain a benzimidazole-containing fragment, and then under the action of linking reagent C, under mild conditions, such as room temperature or slightly heated to 40 to 50 degrees Celsius, the reaction is 2 to 4 hours (hour), and finally 5- (1H-pyrazole-1-yl) -1H-benzo [d] imidazole-2-carboxylic acid is synthesized. Each method has its advantages and disadvantages. In actual operation, it is necessary to comprehensively consider the availability of raw materials, cost, yield and many other factors, and choose the best one to use.

5- (1H-pyrrole-1-yl) -1H-benzo [d] imidazole-2-carboxylic acid, which has unique physicochemical properties. Its appearance is often white to light yellow crystalline powder, and its properties are stable at room temperature and pressure.
Its solubility is slightly soluble in water, but it shows good solubility in some organic solvents such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF), which paves the way for its application in the chemical and pharmaceutical fields.
When it comes to the melting point, it is about 280-290 ° C. This higher melting point indicates that the intermolecular force is strong and the structure is stable. When heated, the properties remain stable before the melting point is reached; after the melting point is reached, it gradually melts into a liquid state.
Then talk about its chemical activity, because the molecular structure contains imidazole ring and pyrrole group, the two give the compound significant reactivity. The nitrogen atom on the imidazole ring has a lone pair of electrons, which is easy to complex with metal ions to form metal complexes, and has emerged in the field of catalysis. Pyrrole groups make the compounds have certain aromaticity and participate in electrophilic substitution reactions, such as halogenation and nitrification, which lay the foundation for organic synthesis of new compounds. The physicochemical properties of 5- (1H-pyrrole-1-yl) -1H-benzo [d] imidazole-2-carboxylic acids have laid the foundation for their wide application in materials science, drug research and development, catalytic chemistry and other fields. With its unique structure and properties, it shines brightly in modern chemical research and industrial production.

I don't know what you mean by "5 -% 281H -% E5% 90% A1% E5% 92% AF - 1 -% E5% 9F% BA% 29 - 1H - %E8%8B%AF%E5%B9%B6%5Bd%5D%E5%92%AA%E5%94%91 - 2 -% E7% A1% AB% E9% 86% 87". This expression is strange and difficult to understand. However, if it is about the price of nitrate in the market, the ancient world, the use of nitrate, or alchemy, medicine, fire utensils, etc.
In the way of alchemy, sorcerers seek longevity, and take nitrate as the material. At that time, the price may be slightly higher for all parties due to the prosperity of alchemy, but the price may vary depending on the region, supply and demand. Where the product is abundant, the price may be flat; where the product is rare and there are many people seeking it, the price may be high.
When used in medicine, doctors treat diseases with their characteristics, and the price is also determined by the market conditions. Pharmaceutical merchants purchase, transship, and sell, and there are fees at every level, and the price fluctuates.
As for the production of firearms, if there are frequent wars, the demand for firearms will increase greatly, and the demand for nitrate will also increase, and the price will rise. On the contrary, when there is peace, the demand is small, and the price may drop.
However, the market price of ancient times is difficult to retain with certainty. There are great differences in different places, and times change, and prices are also different. Or due to natural disasters, wars, decrees, etc., the price of nitrate can change. In a nutshell, its price is impermanent and rises and falls with many causes.

5- (1H-pyrazole-1-yl) -1H-benzo [d] imidazole-2-carboxylic acid, this substance is related to safety and toxicity, and needs to be carefully observed.
Looking at this compound, the structure of pyrazolyl is connected to benzimidazole carboxylic acid, and the structure is unique. However, the safety and toxicity of such nitrogen-containing heterocyclic compounds must be analyzed in multiple ways.
First, safety. In terms of stability, such heterocyclic structures may have certain stability under normal circumstances, and are not easy to decompose spontaneously and cause danger. However, under specific conditions, such as high temperature, strong acid and base, or in case of special chemical reagents, or react, endangering safety. If used in industrial production, the storage, transportation and other links in the production process must be operated according to specifications to ensure its stability and prevent accidents.
And toxicity. Such nitrogen-containing heterocyclic compounds may have certain biological activities, or may be toxic to living organisms. Ingested orally, or through skin contact, breathing and inhalation, they can enter the body. In living organisms, or interact with biological macromolecules, such as proteins, nucleic acids, etc., interfering with normal physiological and biochemical processes. In animal experiments, it may be seen that it has damage to certain organs, such as the liver, kidneys, etc., affecting their normal functions. And in the environment, its degradation products may also be potentially toxic and affect the ecology. Therefore, the safety and toxicity of 5- (1H-pyrazole-1-yl) -1H-benzo [d] imidazole-2-carboxylic acid, whether it is research and development, production, or application, should be strictly investigated, and scientific methods should be used to ensure the safety of people and the environment.