4-Nitro-1H-imidazole-2-carboxylic acid ethylester

4-Nitro-1H-imidazole-2-carboxylate ethyl ester, this is a kind of organic compound. Its appearance is often solid, as for the color, it is either white or nearly white, and has a specific odor.
In terms of solubility, it has different solubility in common organic solvents. In organic solvents such as ethanol and acetone, it exhibits a certain solubility, but in water, its solubility is quite limited. This is due to the functional group properties contained in its molecular structure. The presence of nitro and ester groups affects its affinity in different solvents.
Its chemical properties are active, mainly due to the activity of imidazole ring, nitro group and ester group. Nitro group has strong electron absorption, which can reduce the electron cloud density of imidazole ring, which makes imidazole ring more vulnerable to attack by nucleophiles. For example, under basic conditions, nitro groups can participate in the reaction, and reactions such as substitution or reduction occur.
Ester groups are also active functional groups and are prone to hydrolysis under acid or base catalysis. When hydrolyzed under acidic conditions, 4-nitro-1H-imidazole-2-carboxylic acid and ethanol will be formed; when hydrolyzed under basic conditions, the corresponding carboxylate and ethanol will be formed.
At the same time, the nitrogen atom on the imidazole ring is rich in solitary pair electrons, which can be used as a ligand to coordinate with metal ions to form complexes. Such complexes have potential application value in many fields such as catalysis and materials science.
Due to the existence of a conjugated system in the molecule, this compound will exhibit certain optical properties under the irradiation of specific wavelengths of light, or can be used in the study of optical materials. In short, the diverse chemical properties of 4-nitro-1H-imidazole-2-carboxylate make it a research object of much attention in many fields such as organic synthesis, medicinal chemistry, and materials science.

4-Nitro-1H-imidazole-2-carboxylate ethyl ester, the common synthesis methods are as follows.
First, imidazole is used as the starting material. First, imidazole is nitrified. Under the action of a suitable nitrifying agent (such as the mixed acid of concentrated nitric acid and concentrated sulfuric acid), a nitro group is introduced at the 4 position of imidazole to generate 4-nitroimidazole. Subsequently, 4-nitroimidazole reacts with ethyl chloroformate in the presence of a base (such as sodium carbonate, potassium carbonate, etc.) to realize the ethylation of the 2-carboxyl group, thereby obtaining 4-nitro-1H-imidazole-2-carboxylic acid ethyl ester. This process requires precise control of the reaction conditions, such as the temperature, time and acid mixing ratio during nitrification, otherwise it is easy to cause side reactions to occur and reduce the purity and yield of the product.
Second, imidazole 2-carboxylate can be started from. First, imidazole 2-ethyl carboxylate was nitrified with a suitable nitrifier, and nitro was introduced at the 4th position to directly synthesize the target product 4-nitro-1H-imidazole-2-ethyl carboxylate. This route is relatively simple, but the acquisition of imidazole 2-ethyl carboxylate raw materials may require certain steps. During synthesis, attention should be paid to the selectivity of nitrification reaction and the protection of existing ester groups in the substrate to prevent side reactions such as hydrolysis of ester groups under reaction conditions.
Third, the imidazole ring was synthesized by cyclization reaction. The imidazole ring structure is formed by cyclization of compounds with suitable substituents as raw materials, and nitro and ethyl ester groups are introduced during the reaction process or in subsequent steps. For example, compounds containing functional groups such as nitrogen and carbonyl groups are cyclized under specific catalysts and reaction conditions, and then the target product is prepared by nitrification, esterification and other reaction steps. This method requires careful design of the raw material structure and reaction path to ensure the smooth progress of each step of the reaction, and the reaction conditions are strict to achieve the ideal reaction selectivity and yield.

4-Nitro-1H-imidazole-2-carboxylic acid ethyl ester is useful in the fields of medicine and chemical industry.
In the field of medicine, it can be used as a key intermediate in drug synthesis. Geinimidazole compounds have diverse biological activities. After modification, new drugs with specific pharmacological effects may be obtained. 4-Nitro-1H-imidazole-2-carboxylic acid ethyl ester can be introduced into specific groups through appropriate reaction to prepare antibacterial, antiviral and other drugs. For example, the development of a new type of antibacterial drug, or the use of this intermediate to construct a unique chemical structure, in order to achieve the purpose of efficient antibacterial. < Br >
In the chemical industry, it plays an important role in organic synthesis. It can participate in many organic reactions, such as esterification, substitution and other reactions, laying the foundation for the preparation of more complex organic compounds. Taking the preparation of specific functional materials as an example, by multi-step reaction, it can be connected to other organic molecules, which can endow the material with unique properties, such as optical and electrical properties, or can be used to prepare new optoelectronic materials, which can be used in electronic display and other industries.
And because its structure contains active groups such as nitro and ester groups, chemists can use this to design various reaction paths, expand its application in different fields, and make it play an important role in modern chemical synthesis and related industries.

The market price of ethyl 4-nitro-1H-imidazole-2-carboxylate is difficult to determine. This is due to changes in market conditions, and the price shifts with many factors.
Looking at the past, the price of chemical raw materials often depends on the state of supply and demand. If there are many people who want this product, but there are few people who produce it, the price will tend to rise; conversely, if the supply exceeds the demand, the price may drop. And the cost of raw materials is also a major factor. The price of all kinds of raw materials required to make this product can affect the price of ethyl 4-nitro-1H-imidazole-2-carboxylate.
Also, whether the production process is advanced or not is related to cost. If the new technology is developed, it can reduce consumption and increase production, and the price may change accordingly. Furthermore, market competition, trade policies, current turbulence, etc., will also affect the price.
To know the exact price, you should carefully observe the real-time market conditions of the chemical trading market, or consult the merchants and brokers in the industry to obtain a near-real price. And it is advisable to observe the changes in the market and understand the trend of the price.

4-Nitro-1H-imidazole-2-carboxylate ethyl ester, this is an organic compound. Its storage conditions are quite important, which is related to the stability and quality of this substance.
This substance should be stored in a cool, dry and well-ventilated place. A cool environment can suppress its chemical reactions caused by excessive temperature and prevent its deterioration. If the temperature is too high, it may cause a significant increase in molecular activity, triggering adverse reactions such as decomposition and polymerization, which will damage its chemical structure and properties.
It is indispensable for drying, due to moisture or interaction with the compound. Water molecules may participate in chemical reactions, causing hydrolysis and other phenomena to occur, changing its chemical composition. And the humid environment is easy to breed microorganisms, which will also cause adverse effects on them.
Well ventilated can disperse the volatile substances that may be generated in time to avoid their local accumulation and reduce safety risks. At the same time, it can maintain the fresh air in the storage space and prevent harmful gases from contacting the compound and causing qualitative change.
When storing, it should also be kept away from fire and heat sources, because it has certain chemical activity, in case of open fire, hot topic or cause combustion, explosion and other hazards. And should be stored separately from oxidants, acids, alkalis, etc. Because of its active chemical properties, contact with the above substances, or trigger violent chemical reactions, endangering safety.
In addition, the storage area should be equipped with suitable materials to contain leaks to prevent accidental leaks and deal with them in time to reduce harm. For parameters such as temperature and humidity of the storage environment, it is advisable to set up a special person to regularly monitor records to ensure that the requirements are always met, so that 4-nitro-1H-imidazole-2-carboxylate can be properly preserved to maintain good quality and performance.