4-BROMO-2-NITRO-1H-IMIDAZOLE

4-Bromo-2-nitro-1H-imidazole has a wide range of uses. In the field of pharmaceutical synthesis, it is often a key intermediate. Geimidazole compounds have a variety of biological activities, such as antibacterial, antiviral, anti-tumor and other effects. This compound can be converted into drugs with special curative effects after specific chemical reactions.
It also has important applications in the creation of pesticides. Due to its structural characteristics, pesticide varieties with insecticidal, bactericidal, and weeding properties can be derived, which can help agricultural protection and improve crop yield and quality.
In the field of materials science, or can participate in the preparation of functional materials. For example, it reacts with other substances to form materials with special electrical, optical or thermal properties, which are used in electronic components, optical instruments and other fields.
Furthermore, in organic synthetic chemistry, it is an important building block for the construction of complex organic molecules. With its activity of bromine atoms and nitro groups, it can derive rich organic compounds through many organic reactions, such as nucleophilic substitution, reduction, etc., providing an important material basis for the development of organic synthetic chemistry.

The synthesis method of 4-bromo-2-nitro-1H-imidazole, although it is not contained in the ancient book Tiangong Kaiwu, it can be deduced according to the ancient chemical synthesis method.
Ancient synthesis, selection of heavy materials and reaction conditions. To obtain 4-bromo-2-nitro-1H-imidazole, imidazole is first selected as the initial material. Imidazole has a five-membered heterocyclic structure and is the basis for the reaction.
First, the method of bromination. It can be used in suitable solvents, such as glacial acetic acid, with bromine sources, such as liquid bromine or N-bromosuccinimide (NBS). Glacial acetic acid is used as a solvent, because it is mild, it can make the reaction slow and easy to control. When adding a bromine source, it is necessary to add it slowly to prevent side reactions. This step aims to introduce bromine atoms into the imidazole ring to form 4-bromimidazole.
Second, the method of nitrification. 4-bromimidazole is available and can be used for nitrification. 4-bromimidazole is placed in a mixed acid (mixed with nitric acid and sulfuric acid). The proportion of mixed acid needs to be accurate, and sulfuric acid is used as a dehydrating agent to enhance the electrophilicity of nitric acid. During the reaction, the temperature should be controlled at a low temperature, such as 0-5 ° C. Due to high temperature, it is easy to After this step, the nitro group is introduced, and the final product is 4-bromo-2-nitro-1H-imidazole.
In the synthesis, the separation and purification are also heavy. After the reaction is completed, the product is mixed with impurities. The extraction method can be used to select a suitable extractant, such as dichloromethane, to extract the product. Then by column chromatography, silica gel is selected as the stationary phase, and a suitable eluent is selected to further purify to obtain pure 4-bromo-2-nitro-1H-imidazole.

4-Bromo-2-nitro-1H-imidazole is one of the organic compounds. Its physical properties are very important, related to its application and characteristics.
First word appearance, this compound is often in a solid state, but the specific appearance may vary depending on the purity and preparation method. Pure 4-bromo-2-nitro-1H-imidazole, or white to light yellow crystalline powder, fine texture, or have a certain luster under light.
Melting point is one of its key physical properties. After many measurement experiments, its melting point is roughly in a specific temperature range. This melting point characteristic is of great significance in the identification and purification of the compound. If the melting point is too high or too low, it can suggest that the purity of the compound is poor. The presence of capping impurities often makes the melting point deviate from the normal range.
In terms of solubility, 4-bromo-2-nitro-1H-imidazole behaves differently in different solvents. In common organic solvents such as dichloromethane and chloroform, it has a certain solubility. This property is conducive to its use as a reactant or intermediate in organic synthesis reactions, and it is dissolved with suitable solvents to make the reaction easier. However, in water, its solubility is relatively small, because its molecular structure contains hydrophobic groups and the interaction with water molecules is weak.
In addition, the density of this compound is also a specific value. Density, as an intrinsic property of substances, is valuable in chemical production, storage and transportation. Understanding its density can help to determine the choice of storage containers, and the calculation of weight and volume during transportation.
The physical properties of 4-bromo-2-nitro-1H-imidazole, such as appearance, melting point, solubility and density, are of great significance in the research, synthesis and practical application of organic chemistry, providing key basic data for the development of related work.

In today's world, business conditions are unpredictable, and it is difficult to hide the market price of 4-bromo-2-nitro-1H-imidazole. Its price often changes for many reasons, just like the impermanence of the situation.
The first to bear the brunt is the balance between supply and demand. If there are many people in the market who want this product, but the supply is small, the price will rise; on the contrary, if the supply exceeds the demand, the price will drop automatically. Changes in weather, geographical location, and personnel can all lead to an imbalance between supply and demand. For example, if the origin encounters a disaster, resulting in a sharp drop in output and no reduction in demand, the price will rise like an arrow.
Furthermore, the price of raw materials also affects the market. The system of imidazole requires all kinds of raw materials, and the price of raw materials rises and falls, directly leading to the price of the product. If the price of raw materials is high, the manufacturing cost will increase, and the selling price will increase; if the price of raw materials falls, the cost will decrease, and the price will also decrease accordingly.
The difficulty and advanced of the process are also the key. If the process is complex and consumes a lot of manpower, material resources, and financial resources, the price will not be low; if there is a new and ingenious process that can save costs and increase output, the price may decrease.
In addition, the state of market competition also affects its price. Competing with the industry, various means are used, or prices are reduced to compete for customers, or quality is improved to outperform others. If the competition is fierce, the price may change accordingly.
Looking at the past market, the price of 4-bromo-2-nitro-1H-imidazole fluctuates from time to time. The price is uncertain due to temporary changes in supply and demand, or changes in raw material prices. To know the exact price, you need to look at the current market conditions, consult the merchants and brokers in the industry, and comprehensively consider the information of all parties before you can get a near-real price.

For 4-bromo-2-nitro-1H-imidazole, many matters need to be taken into account during storage and transportation.
First words storage, this substance should be placed in a cool and dry place. Due to its nature or sensitivity to humidity and temperature, if it is placed in a warm and humid place, it may cause deterioration. For example, too high temperature may cause molecular structure changes, affecting its chemical activity; if the humidity is too high, it may cause deliquescence and damage its purity. It must be stored in a sealed container to prevent contact with outside air, water vapor and other substances. In air, oxygen may cause oxidation, and water vapor may cause hydrolysis and other reactions. And it must be kept away from fire and heat sources, because it may have a certain risk of flammability or thermal decomposition. If it is close to fire and near heat, disaster or disaster may occur.
As for transportation, it should not be ignored. It is necessary to choose the appropriate packaging material according to its chemical characteristics. When using chemical corrosion-resistant materials to ensure that the packaging is not damaged during transportation and the material does not leak. During transportation, the speed should be stable to avoid violent vibration and collision. Violent vibration or collision, or the container is damaged, the material leaks, and the chemical reaction is stimulated by external force, which causes danger. The temperature and humidity of the transportation environment should also be controlled to make it suitable for the stable storage of the substance. The escort should be familiar with the characteristics of this substance and the method of emergency response. In case of an emergency, they can respond quickly to avoid catastrophe.