4-Bromo-1-methyl-1H-benzo[d]imidazole

4-Bromo-1-methyl-1H-benzo [d] imidazole This substance has a wide range of uses. In the field of medicine, it is often used as a key intermediate. Benzimidazole compounds have a variety of biological activities, such as antibacterial, antiviral, antitumor, etc. This compound may be chemically modified to produce new drugs with better efficacy and less side effects due to its unique structure.
It also has important applications in the field of materials science. Some benzimidazole derivatives exhibit good optical and electrical properties. 4-Bromo-1-methyl-1H-benzo [d] imidazole may be used as a basic raw material for the development of new photoelectric materials, such as organic Light Emitting Diode (OLED) materials, solar cell materials, etc., to improve material properties and efficiency.
In the field of chemical synthesis, it is an important building block for the synthesis of complex organic compounds. With its bromine atom and methyl activity, other functional groups can be introduced through various chemical reactions, such as nucleophilic substitution, coupling reactions, etc., to construct complex and functional organic molecules, providing an important material basis for the development of organic synthetic chemistry.

4-Bromo-1-methyl-1H-benzo [d] imidazole is an organic compound with specific physical properties. Its appearance is often solid or crystalline, which is ordered at room temperature and pressure due to intermolecular forces. Color is either colorless or white, and pure materials are often like this. If they contain impurities, the color may change.
Melting point is also an important physical property, about 150 ° C - 180 ° C, due to different measurement conditions and purity. Melting point refers to the temperature at which the molecules gain enough energy to overcome the lattice energy and the lattice structure disintegrates.
In terms of solubility, it is slightly soluble in water. Because water is a polar solvent, the compound contains non-polar parts such as benzene ring, resulting in weak interaction with water molecules. However, it is soluble in some organic solvents, such as dichloromethane, chloroform, etc. These organic solvents can form similar forces between molecules of the compound, which is advantageous for dissolution.
In addition, the compound has certain stability and can be stored for a long time under general conditions. In case of strong oxidizing agents, strong acids and bases, or specific high temperatures, light conditions, structure or changes, chemical reactions are induced. Due to the structure of bromine atoms and benzimidazole rings in the molecule, the compound has certain reactivity.

4-Bromo-1-methyl-1H-benzo [d] imidazole is an organic compound with unique chemical properties. The key to its chemical properties lies in the core structure of benzimidazole. This structure contains two fused aromatic rings, which endows the compound with aromaticity. The aromaticity makes it highly stable, and it is not easy to participate in addition reactions, but more prone to electrophilic substitution reactions.
Looking at its substituents, the bromine atom at the 4 position is quite active. The bromine atom is electronegative, which can change the electron cloud density distribution of the benzimidazole ring. This electronic effect makes the electron cloud density of the bromine atom in the adjacent and para-positions relatively low, making these positions more vulnerable to electrophilic attack. For example, under appropriate conditions, an electrophilic substitution reaction can occur, and the bromine atom can be replaced by other groups, such as reacting with nucleophiles, the bromine ion leaves, and the new group accesses, and then a variety of compounds are derived.
The methyl group at position 1, although it is a donator group, has a certain influence on the electron cloud density of the benzimidazole ring, which increases the electron cloud density on the ring, but its donator capacity is relatively limited. However, the presence of methyl groups can change the molecular spatial structure and physical properties. For example, it affects the intermolecular forces, which in turn affect the physical properties such as melting point and boiling point.
In addition, the nitrogen atom of this compound can be used as an electron donor to participate in the reaction due to its lone pair electrons. For example, in some acid-base reactions or coordination reactions, nitrogen atoms can be combined with protons or metal ions to exhibit their unique reactivity.
4-Bromo-1-methyl-1H-benzo [d] imidazoline structure and substituent properties exhibit active and diverse chemical properties, and can be used as an important intermediate in the field of organic synthesis for the synthesis of many organic compounds with special properties.

The synthesis method of 4-bromo-1-methyl-1H-benzo [d] imidazole, as described in ancient books, often follows several paths. First, the method of condensation is based on o-phenylenediamine and bromoacetic acid. First, the o-phenylenediamine and bromoacetic acid are heated and slowed in an appropriate solvent, such as ethanol or dimethylformamide, or accompanied by an appropriate amount of catalyst, such as p-toluenesulfonic acid, to promote its condensation. After the condensation is completed, the product is purified by subsequent steps such as acidification and alkalization to obtain 4-bromo-1-methyl-1H-benzo [d] imidazole. < Br >
Second, 1-methyl-1H-benzo [d] imidazole can also be used as a substrate for bromination. In a suitable reaction system, such as using dichloromethane as a solvent, adding a brominating agent, such as N-bromosuccinimide (NBS), and supplemented with an initiator, such as benzoyl peroxide, under light or heating conditions, the bromine atom selectively replaces the hydrogen at a specific position on the benzimidazole ring to obtain the target product. When operating, pay attention to the reaction temperature and the amount of brominating agent to avoid over-bromination and impure products.
Third, using o-nitroaniline as the starting material, it is prepared through a multi-step reaction. First, o-nitroaniline is reduced to o-phenylenediamine, and iron powder, hydrochloric acid and other reducing agents are used in this step. Then, o-phenylenediamine reacts with bromoacetaldehyde diethyl acetal, and then goes through cyclization, methylation and other steps to obtain 4-bromo-1-methyl-1H-benzo [d] imidazole. Although the steps are complicated, the reaction conditions of each step are relatively mild, and the purity of the product may be higher, but the operation requirements are also high. It is necessary to properly separate and purify each step to preserve yield and purity.

I look at the prices in the market, which often vary from time to time and place, and are also subject to supply and demand. As for 4 - Bromo - 1 - methyl - 1H - benzo [d] imidazole, its market price range is difficult to determine.
The supply and demand of the city is the hub of prices. If there are many people asking for this product, but there are few suppliers, the price will increase; on the contrary, if there are few people asking for it, if there are many suppliers, the price may drop. And the difficulty of production, the price of raw materials, and the simplicity of craftsmanship are all related to prices.
However, if you want to know its exact price, it should be carefully observed by all chemical raw material trading offices and trading platforms. Or consult a chemical product supplier to get a more accurate price. In my opinion, the price may vary depending on the quality, specification, and batch. Generally speaking, if it is an ordinary quality, a small transaction, the price may be slightly higher; if it is a large purchase, and the quality is in line with general industrial use, the price may be slightly lower. However, this is all speculation, and there is no evidence. If you want to know the exact number, it is advisable to visit on the spot.