4-Bromo-1-cyclopropyl-1H-benzo[d]imidazole

4-Bromo-1-cyclopropyl-1H-benzo [d] imidazole has unique chemical properties. In terms of reactivity, its benzimidazole ring conjugate structure is stable, but the bromine atom has high activity and can initiate nucleophilic substitution reactions. In an alkaline environment, nucleophilic reagents such as alkoxides and amines can attack bromine atoms, causing bromine ions to leave and form substitution products.
In terms of physical properties, it is usually a solid in its normal state. Due to the interaction of van der Waals forces and hydrogen bonds between molecules, it has a certain melting point. Its solubility is related to molecular polarity, slightly soluble in water, and its benzimidazole ring and cyclopropyl group are non-polar parts, while its polarity is limited, but it is soluble in common organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide, etc.
From the perspective of stability, under conventional conditions, it is relatively stable to heat and light. However, in the presence of strong acids, strong bases or strong oxidants, its structure may be damaged. For example, in a strong acid environment, nitrogen atoms or protonation on the benzimidazole ring change the molecular charge distribution and reactivity; strong oxidants may cause ring oxidation and ring opening.
In terms of spectral properties, in infrared spectroscopy, the characteristic absorption peaks of benzimidazole rings can be found in a specific wavenumber range, providing a basis for structural identification. In nuclear magnetic resonance spectroscopy, hydrogen and carbon atoms at different positions show unique chemical shifts due to differences in their chemical environments, which help to determine the connection mode and spatial configuration of each atom in the molecule. This is a summary of the chemical properties of 4-bromo-1-cyclopropyl-1H-benzo [d] imidazole.

The common synthesis methods of 4-bromo-1-cyclopropyl-1H-benzo [d] imidazole generally include the following.
First, the starting materials are o-phenylenediamine and cyclopropylcarboxylic acid. First, the o-phenylenediamine and cyclopropylcarboxylic acid are heated in a suitable solvent in the presence of a dehydrating agent such as polyphosphoric acid or phosphorus oxychloride. During this process, the two amino groups of o-phenylenediamine are condensed with the carboxyl group of cyclopropylcarboxylic acid, and the dehydration forms a benzimidazole ring system. After the reaction is completed, the product is precipitated by cooling, pouring into ice water, and then adjusting the pH value with an appropriate alkali solution such as sodium hydroxide solution, and then filtered, washed, and dried to obtain a crude product. The crude product is refined by column chromatography or recrystallization to obtain pure 4-bromo-1-cyclopropyl-1H-benzo [d] imidazole.
Second, 4-bromo-1H-benzo [d] imidazole is used as a raw material to react with cyclopropyl halides such as cyclopropyl bromide or cyclopropyl chloride under basic conditions. Commonly used bases include potassium carbonate, sodium carbonate, etc., which are heated and stirred in a suitable organic solvent such as N, N-dimethylformamide (DMF) or acetonitrile. Cyclopropyl halide forms carbonegative ions under the action of alkali, attacks the nitrogen atom of 4-bromo-1H-benzo [d] imidazole, and undergoes a nucleophilic substitution reaction to form the target product. After the reaction is completed, the solvent is removed by vacuum distillation, the residue is diluted with water, and then extracted with an organic solvent. The extract is dried, concentrated, and purified by column chromatography or recrystallization.
Third, the o-nitroaniline is used as the starting material. First, 4-bromo-2-nitroaniline is obtained by diazotization and bromination reaction. Then, 4-bromo-2-nitroaniline is reduced by reduction reaction, such as iron powder, hydrochloric acid or lithium aluminum hydride as reducing agents, the nitro group is reduced to an amino group to obtain 4-bromo-phthalamine. Then 4-bromo-phthalamine and cyclopropylcarboxylic acid are prepared according to the condensation step of the first method above to obtain 4-bromo-1-cyclopropyl-1H-benzo [d] imidazole. During the reaction process, the reaction conditions at each step need to be finely regulated in order to obtain products with higher yield and purity.

4-Bromo-1-cyclopropyl-1H-benzo [d] imidazole, which is useful in various fields.
In the field of pharmaceutical research and development, it can be a key raw material for the creation of new drugs. Because of its unique chemical structure or specific biological activity, it can act on specific targets in the human body to fight diseases. For example, for some difficult diseases, researchers may use its structural characteristics to carefully design synthetic routes to develop specific drugs for the well-being of patients.
In the field of materials science, it also has potential uses. It can participate in the preparation of materials with special properties, or as optical materials, giving materials unique optical properties; or as electrical materials, optimizing the electrical conductivity of materials, etc. Because of its active chemical properties, it can react with a variety of substances to construct new materials with excellent performance, meeting the special needs of materials in different scenarios.
Furthermore, in the field of organic synthetic chemistry, it is often used as an important intermediate. Chemists can use a series of chemical reactions on it, such as substitution reactions, addition reactions, etc., to construct more complex organic molecular structures, enrich the variety of organic compounds, promote the development of organic synthetic chemistry, and lay the foundation for the synthesis of more novel and unique organic compounds. This substance plays an indispensable role in many key fields such as medicine, materials, and organic synthesis, and is indeed an important member of the chemical field.

4 - Bromo - 1 - cyclopropyl - 1H - benzo [d] imidazole is a rather special organic compound, which may be useful in scientific research and other fields. However, it is not easy to determine its market price. The price of this compound often varies due to many factors.
First, the difficulty of preparation has a great impact. If its synthesis requires complicated steps, rare raw materials or harsh reaction conditions, the cost will be high and the price will be high. The quality of the synthesis process is related to the yield and purity, which in turn affects the price.
Second, market demand is also the key. If there is strong demand for it in many scientific research projects or industrial production, the supply will exceed the demand, and the price will rise; conversely, the demand will be weak, and the price may stabilize or even decline.
Third, the source of supply also plays a role. Different suppliers may offer different prices due to differences in production scale, technical level, and operating costs. Large suppliers may be able to provide relatively favorable prices due to their scale advantages.
At present, I cannot obtain the exact market price of this compound. However, you can find chemical product trading platforms, reagent supplier websites, or consult chemical industry experts and practitioners to obtain more accurate price information. First, the price of 4 - Bromo - 1 - cyclopropyl - 1H - benzo [d] imidazole is volatile due to a variety of factors and must be investigated according to specific market conditions.

4-Bromo-1-cyclopropyl-1H-benzo [d] imidazole is an organic chemical substance. The most important thing for its storage is the cleanliness and dryness of the environment. It should be placed in a cool and well-ventilated place, away from fires and heat sources. If this substance is heated or exposed to open flames, it may cause dangerous changes.
And its storage place should be separated from oxidants, acids, bases, etc., and must not be mixed. Because of its active chemical properties, it comes into contact with various chemicals, or reacts violently, causing harm.
In storage devices, there is also attention to. A sealed container should be used to prevent it from contacting the air and causing biological change. The material of the container used, when compatible with 4-bromo-1-cyclopropyl-1H-benzo [d] imidazole, will not have the risk of corrosion and leakage.
Furthermore, the storage place should be guarded by a special person. The caretaker should be familiar with the properties of this object and know the rules of its storage. Daily inspections, pay attention to whether the container is damaged, leaking, and whether the ambient temperature and humidity are abnormal. If there is any change, dispose of it quickly according to the established method to ensure safety and safety.
In conclusion, the storage of 4-bromo-1-cyclopropyl-1H-benzo [d] imidazole is related to safety and quality, and the above requirements must be followed to be safe.