4-aminoimidazole-5-carboxamide

4-Aminoimidazole-5-carboxamide, Chinese translation 4-aminoimidazole-5-carboxamide, its chemical structure is as follows:
This compound contains an imidazole ring, the imidazole ring is a five-membered heterocycle, composed of two nitrogen atoms and three carbon atoms, with aromatic properties. At the 4th position of the imidazole ring, there is an amino group ($- NH_ {2} $). The amino group is composed of nitrogen atoms and two hydrogen atoms. The nitrogen atom is covalently bonded to the imidazole ring. The presence of the amino group endows the compound with certain basicity and reactivity. A formamide group ($- CONH_ {2} $) is attached to the imidazole ring at position 5. In the formamide group, the carbon atom is connected to the oxygen atom by a double bond, the nitrogen atom is connected by a single bond, and the nitrogen atom is connected to two hydrogen atoms. The formamide group makes the compound have a certain polarity and hydrophilicity.
This chemical structure makes 4-aminoimidazole-5-carboxamide important in the fields of biochemistry and medicinal chemistry. For example, it can be used as an intermediate for the synthesis of bioactive purine nucleotide analogs, and plays an important role in cell metabolism and signal transduction studies. Due to its structural similarity to purine nucleotides, it can participate in related biochemical reactions, providing an entry point for the study of nucleic acid metabolism and related disease mechanisms.

4-Aminoimidazole-5-carboxamide (4-aminoimidazole-5-formamide), which is often referred to as "AICA". This substance has a wide range of uses and is of great value in many fields such as medicine and biochemistry.
In the field of pharmaceutical research and development, AICA plays a key role in the development of anti-tumor drugs. Tumor cells grow rapidly and require huge nucleotides. As an intermediate for nucleotide synthesis, AICA can affect the nucleotide metabolism process of tumor cells. By interfering with AICA-related metabolic pathways in tumor cells, it may inhibit the proliferation and survival of tumor cells, providing new ideas and targets for the design of anti-tumor drugs.
In the field of biochemistry, AICA is also an important tool for exploring cellular metabolic pathways. Intracellular nucleotide synthesis is a complex process, and AICA is involved in the purine nucleotide synthesis pathway. By studying the metabolic changes of AICA in cells, it is possible to gain insight into the regulatory mechanisms of purine nucleotide synthesis, such as enzyme activity regulation and gene expression regulation. This helps to reveal the molecular mechanisms of cell growth, differentiation and disease development.
In addition, in the field of nutrition and health, AICA is closely related to energy metabolism. Studies have found that AICA can activate specific signaling pathways in cells, such as the AMP-activated protein kinase (AMPK) pathway. This pathway plays a central role in regulating cellular energy balance, fatty acid oxidation, and sugar metabolism. Moderate regulation of AICA levels may improve the body's energy metabolism, and has potential significance for the prevention and treatment of metabolic diseases such as obesity and diabetes.
In summary, 4-aminoimidazole-5-carboxamide has a wide range of uses in the fields of medicine, biochemistry, and health. As research continues, more potential uses may be discovered and applied.

4-Aminoimidazole-5-carboxamide (4-aminoimidazole-5-formamide), its physical properties are as follows:
This substance is mostly white or off-white crystalline powder at room temperature, and it is fine in appearance. Its powder texture is uniform, and there are no impurities or agglomeration visible to the naked eye.
When it comes to the melting point, it is about 170-172 ° C. At this temperature, the substance gradually melts from solid to liquid, and the phase state changes. This melting point characteristic is relatively fixed, which can be an important basis for identifying the substance.
In terms of solubility, it is slightly soluble in water, and the dissolution rate in water is slow. After stirring for a long time, it can only be partially dissolved, and the solution is slightly turbid. However, it can be soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dimethyl formamide (DMF). In these organic solvents, it can be dispersed and dissolved quickly to form a uniform solution system. This difference in solubility is due to the choice of solvent in chemical synthesis and related experimental applications. < Br >
Its density is not exactly the specific value recorded in ancient books, but according to modern chemical research on similar structural compounds, its density is equivalent to that of common organic compounds. During storage and use, due to its density characteristics, it can be stably stored in general containers without special fluidity or sedimentation.
The physical properties of 4-aminoimidazole-5-carboxamide are unique, which is of great significance for its application in many fields such as chemistry and biology. It is closely related to the identification of substances and the setting of reaction conditions.

The synthesis method of 4-aminoimidazole-5-carboxamide (4-aminoimidazole-5-formamide, referred to as AICA) has been used in ancient times, and many families have applied wonderful methods.
First, 4-amino-5-cyanimidazole is used as the starting material. The method of hydrolysis of this substance, that is, under a suitable acid-base environment and temperature, the cyano group is gradually converted into formamide group to obtain 4-aminoimidazole-5-carboxamide. When hydrolyzing, it is necessary to observe the reaction process and regulate the reaction conditions. Due to too strong acid-base and too high temperature, the product may be impure or the yield may be low.
Second, 4-aminoimidazole-5-carboxylate can also be used as the starting material. With appropriate reagents, under mild conditions, the ester group is converted into a formamide group. In this process, the choice of reagents and the consideration of the reaction solvent are all crucial. The solvent needs to be able to dissolve the reactants without side reactions with the reactants and products, and at the same time promote the reaction rate.
Third, the imidazole ring is constructed through a multi-step reaction. First, a simple compound containing nitrogen and carbon, through condensation, cyclization and other reactions, the prototype of the imidazole ring is constructed, and then the amino group and the formamide group are introduced at a specific position. Although this path is complicated, if the reaction conditions of each step are precisely controlled, high-purity 4-aminoimidazole-5-carboxamide can also be obtained. During the synthesis process, the separation and purification of intermediates is extremely critical, otherwise the accumulation of impurities will affect the quality of the final product.
The above synthesis methods have advantages and disadvantages. In practical application, it is necessary to weigh and choose factors such as the availability of raw materials, cost considerations, and purity requirements of the product to achieve the purpose of synthesis.

4 - aminoimidazole - 5 - carboxamide, Chinese name 4 - aminoimidazole - 5 - formamide, the price in the market varies depending on the quality, source and purchase quantity. If it is an ordinary chemical reagent grade with a purity of about 98%, buy a small amount, and the price per gram may be in the tens of yuan. If the purchase quantity is large, such as a hundred grams, the unit price may be reduced to about ten yuan per gram.
If it is a pharmaceutical grade, the purity requirements are higher and the price is higher. Pharmaceutical grade products with a purity of more than 99% may cost more than 100 yuan per gram. And its preparation process is complicated, and strict quality control is required, resulting in increased costs and high prices.
In addition, different merchants have different pricing, and imported products are often more expensive than domestic ones. When purchasing, it is advisable to consult different suppliers to get the best price. However, the price often changes due to market supply and demand, raw material prices and production process improvements. The actual price shall be subject to real-time inquiry.