4-Amino-1H-imidazole-5-carboxamide

4 - Amino - 1H - imidazole - 5 - carboxamide, Chinese name 4 - amino - 1H - imidazole - 5 - formamide, its chemical structure is as follows.
This compound belongs to a nitrogen-containing heterocyclic organic compound. Its core structure is an imidazole ring, which is a five-membered heterocyclic ring composed of two nitrogen atoms and three carbon atoms, and has aromatic properties. At the 1 position of the imidazole ring, a hydrogen atom is connected to form the basic structure of 1H - imidazole.
At the 4 position of the imidazole ring, there is an amino group (-NH2O) connected. The nitrogen atom in the amino group has a pair of lone pair electrons, which endows the compound with certain alkalinity and nucleophilicity, and can participate in many chemical reactions, such as reacting with acids to form salts, or as nucleophilic reagents in some nucleophilic substitution reactions.
In the 5 position of the imidazole ring, a formamide group (-CONH ²) is connected. In the formamide group, the carbonyl group (C = O) has a certain electron absorption, and the lone pair electrons on the amide nitrogen atom are conjugated with the carbonyl group, which makes the whole formamide group unique in chemical properties. This group can participate in a variety of reactions, such as hydrolysis reactions. Under the catalysis of acids or bases, it can be hydrolyzed into carboxylic acids and
Overall, the chemical structure of 4-Amino-1H-imidazole-5-carboxamide, due to the presence of imidazole ring, amino group and formamide group, makes it have unique chemical properties and reactivity, and has important applications and research value in organic synthesis, medicinal chemistry and other fields.

4-Amino-1H-imidazole-5-carboxamide (4-amino-1H-imidazole-5-formamide), referred to as AICA, is widely used.
First, in the field of pharmaceutical research and development, its role is significant. AICA and its derivatives have potential biological activity and can be used as pharmaceutical intermediates to create antiviral and anti-tumor drugs. For example, in the development of antiviral drugs, their structural characteristics enable them to precisely act on the key link of virus replication or interfere with viral nucleic acid synthesis, thereby inhibiting viral proliferation. In the field of anti-tumor, it may affect the metabolic pathway of tumor cells and induce tumor cell apoptosis, providing help to overcome cancer problems.
Second, in the field of biochemical research, AICA also plays an important role. It is an intermediate product of the purine nucleotide synthesis process. By exploring the metabolic pathways in which it participates, researchers can gain insight into the mechanism of intracellular nucleic acid synthesis and clarify the basic laws of life activities. For example, by adjusting the concentration of AICA in the cellular environment, observing the rate and type of cell nucleic acid synthesis changes, laying the foundation for revealing the mechanism of gene expression regulation.
Third, AICA is also useful in food and feed additives. Adding it in moderation may improve the nutritional structure and quality of food and feed. Adding it to animal feed can promote animal metabolism, enhance immunity, and improve breeding efficiency; it can be used in food to optimize food flavor, extend shelf life, and meet the public's pursuit of higher quality food.
AICA has extraordinary uses in many fields such as medicine, biochemical research, and food and feed, and has made great contributions to promoting the development of related industries.

4-Amino-1H-imidazole-5-carboxamide (4-amino-1H-imidazole-5-formamide), the physical properties of this substance are very important, and it is related to its application in many fields.
Its appearance is often white to off-white crystalline powder. This state is easy to identify and distinguish, and its purity and quality can be preliminarily judged in various experiments and production scenarios.
The melting point is also one of the key physical properties, about 170-174 ° C. The stability of the melting point is of great significance for its purification, identification and quality control. In the process of chemical synthesis, the determination of the melting point can provide an important basis for whether the reaction is complete and the product is pure.
In terms of solubility, it is slightly soluble in water. This property determines that in a system with water as a solvent, it is necessary to pay attention to its solubility and dispersion. In the field of drug development and other fields, if this substance is used as an active ingredient, its solubility in water may affect the dosage form design and absorption of the drug in vivo. In organic solvents, such as ethanol, its solubility also has a certain degree of performance. Moderate solubility can be used to select a suitable solvent for its separation, extraction or reaction operation.
Furthermore, although the density of this substance is not a property that is frequently considered on a daily basis, in some precise chemical production or research scenarios, the knowledge of density is helpful for the calculation of materials and the setting of related process parameters. Its density is within a certain range and has guiding value for the mixing and separation of substances under specific conditions.
In summary, these physical properties of 4-Amino-1H-imidazole-5-carboxamide play a unique role in the research and practice of chemistry, medicine and many other fields, from appearance to melting point, solubility, density, etc., and are of great significance.

The synthesis method of 4 - Amino - 1H - imidazole - 5 - carboxamide (4 - amino - 1H - imidazole - 5 - formamide, referred to as AICA), through the ages, many parties have their own wonderful methods.
First, a specific nitrogen-containing heterocyclic compound is used as the starting material. First, the raw material and a suitable acylation reagent are acylated under mild reaction conditions, and the acyl group is skillfully introduced. Then, the acylation product is subjected to a carefully designed amination step, and the amino group is precisely introduced at a specific position with the help of a suitable amination reagent. In this process, the control of the reaction conditions is extremely critical, and the temperature, pH and reaction time need to be strictly regulated to ensure that the reaction proceeds according to the expected path and obtains the target product with higher yield and purity.
Second, there are also imidazole derivatives as starters. First, the specific functional groups of the imidazole derivatives are activated to participate in the subsequent reaction with better activity. Then, with the reagents containing carboxylamide groups, the condensation reaction occurs in a specific solvent environment with the help of a catalyst. The choice of this catalyst is of paramount importance, and its activity and selectivity are directly related to the reaction efficiency and product purity. The reaction mixture still needs to be carefully separated and purified in the future. After classical methods such as column chromatography and recrystallization, pure 4-Amino-1H-imidazole-5-carboxamide can be obtained.
Third, there is a strategy of using simple small molecule compounds as starting materials to construct target molecules through multi-step tandem reactions. First, the imidazole ring skeleton is gradually built between the small molecule compounds through an ingenious reaction mechanism. Then, on the formed imidazole ring, amino groups and carboxamide groups are introduced one by one through selective modification. Although there are many steps in this strategy, each step is highly selective and controllable. If operated properly, it can also efficiently synthesize 4-Amino-1H-imidazole-5-carboxamide. In short, the synthesis methods have their own advantages and need to be carefully selected according to actual needs and conditions.

4 - Amino - 1H - imidazole - 5 - carboxamide, that is, 4 - amino - 1H - imidazole - 5 - formamide, there are many things to pay attention to when using this substance.
Bear the brunt, and safety is of paramount importance. This substance may be toxic and irritating, and can cause discomfort or even harm health when it touches the skin, eyes or inhales its dust. When using it, it is necessary to strictly follow safety procedures and wear appropriate protective equipment, such as gloves, goggles and masks, for safety.
Furthermore, its storage should not be underestimated. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources to prevent deterioration or cause safety accidents. And it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed to avoid dangerous chemical reactions.
During use, precise operation is also the key. According to the specific needs of the experiment or production, the substance should be accurately weighed and measured to ensure that the dosage is correct. The operation should be carried out in the fume hood, so that the harmful gases that may be generated are discharged in time to avoid accumulation in the experiment or working environment.
In addition, the disposal of its waste must also be treated with caution. It should not be discarded at will, but should be properly collected and disposed of in accordance with relevant environmental regulations to prevent pollution to the environment.
In short, when using 4 - Amino - 1H - imidazole - 5 - carboxamide, from safety protection, storage conditions, operating specifications to waste disposal, every link cannot be ignored, so as to ensure the safety and compliance of the use process.