4(5)-IODO-1-METHYLIMIDAZOLE

4- (5-iodine-1-methylimidazole) has a wide range of uses. In the field of medicine, it is often a key intermediate for the synthesis of many effective drugs. Due to the unique biological activity of imidazole compounds, this substance can be cleverly chemically modified to produce drugs with antibacterial, antiviral, anti-tumor and other effects, bringing hope for the treatment of many difficult diseases.
In materials science, it also plays an important role. It can be introduced into polymer materials through specific chemical reactions, giving materials unique properties such as good stability and conductivity, thus expanding the application of materials in electronic devices, optical materials and other fields.
In chemistry research, it is an important building block for organic synthesis. Chemists use its unique structure to explore various novel reaction paths, synthesize organic compounds with diverse structures and specific functions, and promote the continuous progress of organic chemistry theory and technology.
In the field of biochemistry, it may be used as a biological probe. With its interaction with specific biomolecules, it helps scientists gain in-depth insight into microscopic processes in organisms, such as the structure and function of proteins and nucleic acids, providing powerful tools for life science research.
In conclusion, 4- (5-iodine-1-methylimidazole) is of great value in many scientific fields, and its potential uses are expected to continue to expand with the deepening of research.

The physical properties of 4- (5-iodine-1-methylimidazole) are as follows:
This compound is an important intermediate in organic synthesis. Looking at its physical properties, it is either a solid at room temperature or a viscous liquid due to the structural characteristics of substituents and molecules. Its melting point and boiling point are key physical parameters, but the specific values vary depending on the exact structure and purity. Generally speaking, organic compounds containing iodine have higher melting points and boiling points than similar non-iodine substitutes due to the large relative atomic mass of iodine atoms and the enhanced intermolecular force.
In terms of solubility, due to its imidazole ring and methyl and iodine atoms, it has good solubility in organic solvents. For example, common polar organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), etc., can effectively disperse the compound molecules and dissolve them by virtue of the van der Waals force and dipole-dipole interaction between molecules. In water, due to the fact that the polarity of the whole molecule is not extremely strong, and the hydrophobic effect of iodine atoms and methyl groups, its solubility is poor.
Appearance may be colorless to light yellow, because although there is no typical conjugated large π bond in the molecular structure to cause significant color absorption, the presence of iodine atoms or cause the distribution of electron clouds to change, triggering weak color changes. Density or greater than water, because the relative atomic weight of iodine atoms is large, which increases the overall molecular weight.
In addition, its stability is also an important physical property. Under normal environmental conditions, if there is no special reagent or condition stimulation, the structure is relatively stable. However, under extreme conditions such as strong oxidizing agents, reducing agents or high temperatures, imidazole rings, iodine atoms and methyl groups may undergo chemical reactions, resulting in structural changes.

To prepare 4- (5-iodine-1-methylimidazole), the following method can be followed.
First take an appropriate amount of 1-methylimidazole as the starting material, and the nitrogen atom in its structure has a certain nucleophilicity. Place 1-methylimidazole in a suitable reaction vessel and add an appropriate amount of inert solvent, such as dichloromethane, to create a homogeneous reaction environment.
Then, slowly add an iodine-substituted reagent, such as N-iodosuccinimide (NIS). This iodine-substituted reagent can release an active iodine source in the reaction system. Under the condition of mild heating or stirring at room temperature, the hydrogen atom at the 5-position of 1-methylimidazole has certain activity due to the influence of the electronic effect of nitrogen atoms, and can be replaced by iodine atoms to generate 4- (5-iodine-1-methylimidazole) intermediates.
The reaction process can be monitored by thin layer chromatography (TLC). When the raw material point is basically eliminated, the reaction reaches the expected level. After the reaction is completed, pour the reaction mixture into an appropriate amount of water and extract it with dichloromethane for multiple times. Combine the organic phases and dry them with anhydrous sodium sulfate to remove the moisture.
Then by reduced pressure distillation, the organic solvent is removed to obtain a crude product. Finally, by column chromatography, a suitable silica gel column and eluent, such as petroleum ether and ethyl acetate mixed in a certain proportion of eluent, the crude product is further purified, the eluent containing the target product is collected, and the solvent is evaporated to obtain pure 4- (5-iodine-1-methylimidazole). The whole process needs to pay attention to the control of reaction conditions to ensure that the reaction is smooth and efficient to improve the yield and purity of the product.

4- (5-Iodine-1-methylimidazole) Many things need to be paid attention to when storing and transporting this substance.
One is related to storage. This chemical substance should be stored in a cool, dry and well-ventilated place. Due to high temperature, or its chemical properties may change, causing decomposition and other conditions; if the humidity is large, it is easy to make it damp, affecting purity and quality. And it should be kept away from fire and heat sources to prevent fire hazards, because it may be flammable or dangerous reactions in contact with fire sources. Furthermore, it needs to be stored separately from oxidants, acids, bases, etc., to avoid chemical reactions caused by mixed storage, resulting in deterioration or safety accidents. The storage area should be equipped with suitable containment materials to prevent leakage and timely treatment.
Second, when transporting, ensure that the packaging is complete and sealed. The packaging material must be able to withstand a certain external force to prevent the container from being damaged due to bumps and collisions during transportation, resulting in material leakage. The transportation process should follow relevant regulations and standards, and select transportation enterprises and transportation tools with corresponding qualifications. Transportation personnel need to be professionally trained and familiar with the characteristics of the substance and emergency treatment methods. Transportation vehicles should be equipped with fire extinguisher materials and leakage emergency treatment equipment. During transportation, avoid high temperature periods and densely populated areas, drive carefully, and avoid violent actions such as sudden braking and sharp turns to ensure transportation safety.

I look at the "4 - (5 - iodine - 1 - methylimidazole) " you are inquiring about, and its market price is difficult to come to a conclusion. Due to the rapid changes in market conditions, it is like the wind and clouds are fickle.
First, the preparation of this compound is difficult and easy, which is related to its cost and price. If the preparation method is complicated, rare raw materials are required, and it has gone through many difficult processes, during which high-risk operations or high-cost equipment are involved, the cost will be high, and the market price will be high. On the contrary, if the preparation method is simple and the raw materials are easy to obtain, the price may be relatively easy.
Second, the situation of market supply and demand also affects its price. If the demand for this product is strong in the fields of medicine, chemical industry, etc., but the supply is limited, the so-called "rare is expensive", its price will rise. If the supply exceeds the demand, the merchant will compete for sales, or reduce the price to promote.
Third, the different manufacturers also lead to different prices. Large manufacturers have large scale and exquisite technology, and the cost may be slightly controllable, but the brand premium may exist; small manufacturers, although the cost may be low, the quality may be difficult to compete with large factories, and the price varies accordingly.
Fourth, regional differences also affect the price. In prosperous cities, the logistics is convenient, but the rent and labor costs are high; in remote places, although the cost is slightly lower, the transportation is inconvenient, and the cost also increases, all of which make the price different.
To sum up, in order to know the exact market price of "4- (5-iodine-1-methylimidazole) ", it is necessary to consult the chemical market and manufacturers, and carefully observe the current supply, demand, cost and other conditions in order to obtain a more accurate number, which cannot be generalized.