2-(Pyridin-4-yl)-1H-benzimidazole-7-carboxylic acid

The chemical structure of 2-%28Pyridin-4-yl%29-1H-benzimidazole-7-carboxylic + acid is composed of benzimidazole ring cleverly connected with pyridyl and carboxyl groups.
Looking at its core, benzimidazole ring is the key structure. This ring is formed by fusing benzene ring and imidazole ring, which has both the aromatic stability of benzene ring and the unique reactivity of imidazole ring. On the imidazole ring, the solitary pair electron of nitrogen atom endows it with weak basic and nucleophilic properties, and can participate in various chemical reactions.
Side chain pyridyl group is connected to the 2-position of benzimidazole ring at the 4-position. The pyridine ring is also aromatic, and the electronegativity of the nitrogen atom in the ring affects the electron cloud distribution, making the pyridine ring more prone to electrophilic substitution than the benzene ring. Under specific reaction conditions, it can become a check point for chemical modification.
Furthermore, the 7-position of the benzimidazole ring is connected with a carboxyl group. The carboxyl group is acidic and can dissociate hydrogen ions under suitable conditions. It can also participate in esterification, amidation and other reactions, which greatly expands the chemical transformation potential of this compound.
Overall, the chemical structure of 2- (pyridine-4-yl) -1H-benzimidazole-7-carboxylic acid integrates a variety of active groups, endowing it with unique chemical properties and potential application value. It may have outstanding performance in pharmaceutical chemistry, organic synthetic chemistry and other fields.

2-%28Pyridin-4-yl%29-1H-benzimidazole-7-carboxylic acid is 2- (pyridine-4-yl) -1H-benzimidazole-7-carboxylic acid. The physical properties of this substance are explained in detail by you.
Its appearance is often solid. As for the color, or it is white to white powder, it is slightly different due to the different preparation methods and purity. Its melting point is one of the key physical properties, but the exact melting point needs to be determined by precise experiments, and different research literature may vary slightly due to differences in measurement conditions.
In terms of solubility, in common organic solvents, such as ethanol, dichloromethane, etc., its solubility is limited and slightly soluble in water. This solubility characteristic is closely related to its molecular structure. The polar groups in the molecule interact with the aromatic structure, causing it to exhibit unique dissolution behavior in different solvents.
Density is also an important physical property. Although the exact value needs to be accurately measured in the laboratory, its approximate range can be inferred from similar structural compounds. Because the molecule contains cyclic structures such as benzimidazole and pyridine, and has carboxyl groups, its density may be relatively high.
In addition, its stability is quite considerable. At room temperature and pressure, if there is no special chemical environment or external factors to interfere, the structure is not easy to change. However, in case of extreme conditions such as strong acids and strong bases, or chemical reactions may occur to cause structural changes.
The above is an approximation of the physical properties of 2- (pyridine-4-yl) -1H-benzimidazole-7-carboxylic acids. If accurate and detailed data are required, rigorous scientific experiments are still required.

To prepare 2- (pyridine-4-yl) -1H-benzimidazole-7-carboxylic acid, there are several common synthesis methods.
One is to start with raw materials containing the structure of pyridine and benzimidazole. First, take a suitable pyridine derivative, so that the 4-position of pyridine has a reactive group, and then meet the compound containing the structure of benzimidazole and the 7-position can be modified. With the help of an appropriate condensing agent, in a suitable temperature and solvent, the two are connected by a condensation reaction, and then the 7-position is carboxylated. For example, in the presence of a base, pyridine-4-boronic acid and 7-halo-1H-benzimidazole are selected. In a mixed solvent such as dioxane-water, the palladium-catalyzed coupling reaction first forms a carbon-carbon bond to obtain 2- (pyridine-4-yl) -1H-benzimidazole, and then a carboxylation group is introduced with a suitable carboxylation reagent, such as carbon dioxide and a strong base, to obtain the target product.
Second, you can start with the construction of a benzimidazole ring. Using o-phenylenediamine and pyridine-4-formaldehyde as starting materials, it is first condensed under acid catalysis to form 1- (pyridine-4-yl) benzimidazole-2-imine intermediate. After oxidation, hydrolysis and other steps, the 2-position substituent is adjusted, and the carboxyl group is introduced at the 7-position at the same time. This process can be carried out according to different reaction conditions and reagents, or the carboxyl precursor, such as cyano, is introduced at the 7-position first, and then hydrolyzed to carboxyl.
Or third, the 2-position is modified with benzimidazole-7-carboxylic acid as the parent nucleus. First, benzimidazole-7-carboxylic acid is prepared, and then the 2-position hydrogen activity is used to halogenate the 2-position, and then it is halogenated with pyridine-4-based reagents, such as pyridine-4-based lithium reagent or pyridine-4-based Grignard reagent. Nucleophilic substitution reaction occurs to obtain 2- (pyridine-4-yl) -1H-benzimidazole-7-carboxylic acid.
All synthesis methods have their own advantages and disadvantages, and it is necessary to weigh the factors such as the availability of raw materials, the ease of control of reaction conditions, the purity and yield of the target product, and choose the most suitable one for synthesis.

2-%28Pyridin-4-yl%29-1H-benzimidazole-7-carboxylic acid is 2- (pyridine-4-yl) -1H-benzimidazole-7-carboxylic acid, which is used in many fields such as medicine and materials.
In the field of medicine, its structure contains benzimidazole and pyridine groups, which have unique biological activities and can be used as potential drug intermediates. Benzimidazole compounds often show antibacterial, antiviral, antitumor and other activities. For example, some benzimidazole derivatives can inhibit the proliferation of tumor cells by binding to specific targets of tumor cells. Therefore, it is speculated that 2- (pyridine-4-yl) -1H-benzimidazole-7-carboxylic acid may be modified and developed as a new anti-tumor drug. And pyridine groups also exist in a variety of drug molecules, which can enhance the affinity of compounds with biological macromolecules and improve drug efficacy.
In the field of materials, because of its rigid planar structure, it can be used to prepare optoelectronic materials. Rigid planar structure facilitates intramolecular charge transfer and conjugation, or makes the compound exhibit unique optical and electrical properties. For example, some benzimidazole-containing structural materials have applications in organic Light Emitting Diodes (OLEDs), solar cells, etc. 2- (pyridine-4-yl) -1H-benzimidazole-7-carboxylic acids may be rationally designed and synthesized to prepare photoelectric materials with excellent performance, which can be used to improve the luminous efficiency and stability of OLEDs, or to improve the photoelectric conversion efficiency of solar cells.
In addition, in the field of chemical research, it can be used as an organic synthesis intermediate for the construction of more complex compounds, providing a variety of options for the development of organic synthesis chemistry, and helping scientists create more new substances with specific properties and functions.

2-%28Pyridin-4-yl%29-1H-benzimidazole-7-carboxylic + acid is 2- (pyridine-4-yl) -1H-benzimidazole-7-carboxylic acid, which is mostly used in the field of medicine and chemical industry. However, in the current market, its prospects can be described as both opportunities and challenges.
Looking at its opportunities, there is a growing demand for innovative compounds in the field of pharmaceutical research and development. This compound has a unique structure or biological activity, which can lay the foundation for the development of new drugs. Nowadays, the research and development of anti-cancer, antiviral and other disease treatment drugs continues to advance. If 2- (pyridine-4-yl) -1H-benzimidazole-7-carboxylic acid is confirmed to have positive effects on disease treatment targets, it must attract the attention of pharmaceutical companies, and the market demand may grow rapidly. And with the improvement of chemical synthesis technology, the efficiency of synthesizing this compound may increase, cost or decrease, paving the way for its large-scale production and marketing activities.
However, the challenges cannot be ignored. The drug development process is long and complex, and requires multiple rounds of rigorous experimental and clinical verification. Although 2- (pyridine-4-yl) -1H-benzimidazole-7-carboxylic acid has potential advantages in structure, it is still unknown whether it can eventually become an effective drug. Many technical problems need to be overcome in the experimental stage, such as improving purity and optimizing reaction conditions. At the same time, the market competition is fierce, and the research and development of similar structural compounds may already be in the way. If other developers make breakthroughs and seize the market first, the market space of this compound may be squeezed. Furthermore, regulations and policies have stricter supervision of pharmaceutical and chemical products, and products need to meet many regulatory requirements from research and development to marketing, which also adds difficulty to their market process.