2-propyl-1H-imidazole-4,5-dicarboxy acid diethyl ester

2-Propyl-1H-imidazole-4,5-dicarboxylic acid diethyl ester, this compound has a wide range of uses. In the field of medicinal chemistry, it is often used as an intermediate in organic synthesis, paving the way for the creation of new drugs. Due to its unique chemical structure, it can participate in a variety of reactions, skillfully combine with different reagents to generate substances with specific biological activities, providing a key foundation for the development of innovative drugs for the treatment of various diseases.
In the field of materials science, it also has its uses. By properly designing and reacting with other compounds, polymer materials with specific properties can be constructed. For example, polymerization with monomers with specific functional groups endows materials with unique optical, electrical or mechanical properties, and shows application potential in optoelectronic devices, high-performance polymer materials and other fields.
In scientific research, it is an important chemical tool. Researchers use it to deeply explore the reaction mechanism and properties of imidazole compounds, deepen their understanding of the basic theory of organic chemistry, and contribute to the theoretical development of related fields. In the study of organic synthesis methodology, as a reactant or model compound, it helps to develop novel and efficient synthesis methods and promotes the continuous progress of organic synthesis chemistry.

Synthesis of 2-propyl-1H-imidazole-4,5-dicarboxylic acid diethyl ester, there have been many ingenious methods in ancient times.
First, propyl imidazole can be reacted with the corresponding esterification reagents and carboxylation reagents under suitable reaction conditions. First, take propyl imidazole as the base, add an appropriate amount of esterification reagent in a specific solvent, such as diethyl sulfate, etc., under mild heating and stirring, so that the two gradually react to form a preliminary connection of ester groups. Then, slowly add carboxylating reagents, such as carbon dioxide or other active reagents containing carboxyl groups, and with the help of catalysts, the carboxyl groups are smoothly introduced into the 4,5 positions of the imidazole ring, thus gradually forming 2-propyl-1H-imidazole-4,5-dicarboxylic acid diethyl ester.
Second, imidazole derivatives substituted with propyl can also be used as starting materials. First, this derivative is reacted with an acylating reagent to form a specific acyl intermediate. Next, the intermediate is esterified with ethanol under the catalysis of an acid or base, and the ester moiety is cleverly constructed. Subsequently, through specific carboxylation means, such as the reaction of halogenated carboxylic acid esters with intermediates, through a series of substitution, rearrangement and other processes, the carboxyl group is carefully introduced to obtain the final target product.
Furthermore, the imidazole ring can be gradually built from the basic raw materials. Starting with appropriate aldose, ketone, amine and other compounds, the imidazole ring skeleton is first constructed through condensation reaction, and in the construction process, the propyl substituent is introduced at the same time. After the imidazole ring is initially formed, carboxylation and esterification reactions are carried out in sequence. For example, first, propionaldehyde is condensed with suitable amines and carbonyl-containing compounds to form an imidazole ring, then a carboxyl group is introduced through a carboxylation reaction, and finally esterified with ethanol under the action of a catalyst. With so many steps, 2-propyl-1H-imidazole-4,5-diethyl dicarboxylate can also be synthesized.

2-Propyl-1H-imidazole-4,5-dicarboxylic acid diethyl ester, this is an organic compound. Looking at its physical and chemical properties, from the appearance, it is often white to light yellow crystalline powder. This state is quite common in many organic compounds. Because of its orderly molecular arrangement, it is stable at room temperature and pressure.
When it comes to solubility, it shows unique properties in organic solvents. Easily soluble in organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF). In dichloromethane, it can be well miscible because it can form suitable intermolecular forces between molecules and dichloromethane molecules, such as van der Waals forces; in DMF, the polar properties of DMF interact with some groups of the compound to help it dissolve. However, it is difficult to dissolve in water because water is a strong polar solvent, and the overall polarity of the compound is relatively weak, and it is difficult to form an effective interaction with water molecules to overcome the strong hydrogen bond between water molecules, so it is difficult to dissolve.
In terms of boiling point, it is about a certain temperature range (in view of the lack of accurate data, it is speculated from similar structural compounds). The boiling point is significantly affected by the intermolecular forces. There are van der Waals forces and certain hydrogen bonds between the molecules of this compound (the nitrogen atom on the imidazole ring can participate in the formation of weak hydrogen bonds). These forces require a certain amount of energy to overcome to make it boil, so the boiling point is in the corresponding range. The melting point is also relatively stable, which reflects the balance between molecular lattice energy and thermal motion. At a specific temperature, the lattice can be broken by thermal motion, and the compound changes from solid to liquid.
Chemically, the ester group in this compound has typical ester chemical activity. Hydrolysis can occur when exposed to acids or bases. Under basic conditions, such as sodium hydroxide solution, the carbonyl carbon of the ester group is attacked by the nucleophilic of hydroxide ions, and carboxylate and alcohol are formed through a series of reactions; under acidic conditions, such as dilute sulfuric acid, the hydrolysis reaction mechanism is different, but corresponding carboxylic acids and alcohols are also formed. The imidazole ring is partially rich in electrons and can undergo electrophilic substitution reactions. For example, with halogenated reagents, halogen atoms can replace hydrogen atoms on the imidazole ring under suitable conditions. This is based on the electron cloud density distribution characteristics of the imidazole ring. Hydrogen atoms at specific positions are easily attacked by electrophilic reagents.

Today, I have a question. What is the price range of 2-propyl-1H-imidazole-4,5-dicarboxylate in the market. This compound is an important intermediate in organic synthesis, often involved in pharmaceutical chemistry, materials science and other fields.
However, its price is not constant and often varies due to multiple factors. First, product purity is the key. For high purity, due to difficult preparation and high cost, the price is high. If the purity is above 99%, the price per gram may be in the hundreds of yuan. Second, the market supply and demand have a great impact. If there are many people who want it, and there are few products, the price will rise; conversely, if the supply exceeds the demand, the price will decline. Third, manufacturers and regions also play a role. Different manufacturers have different pricing due to differences in technology and cost; and regional factors such as transportation costs, which also lead to differences in prices.
Roughly speaking, in ordinary commercial channels, the price per gram for lower purity (such as about 90%) may be in the tens of yuan; for medium purity (around 95%), it may be nearly 100 yuan per gram; for high purity, it may exceed 200 yuan per gram. However, this is only an approximate number. The actual price should be carefully studied according to real-time market conditions.

2-Propyl-1H-imidazole-4,5-diethyl dicarboxylate is an organic chemical. Regarding its safety precautions, the details are as follows:
First, this chemical is potentially toxic or poses a threat to human health. When exposed, it may irritate the skin and eyes, causing redness, swelling, pain and itching. If inhaled or ingested inadvertently, it may damage the respiratory system and digestive system, causing symptoms such as cough, breathing difficulties, nausea, vomiting and abdominal pain. Therefore, when operating, be sure to take appropriate protective measures, such as wearing gloves, goggles and masks, and beware of direct contact.
Second, the chemical is flammable, and in case of open flame or hot topic, there is a risk of combustion and explosion. During storage and use, it should be kept away from fire and heat sources, placed in a cool and well-ventilated place, and stored separately from oxidants, acids, alkalis, etc. Do not mix and transport, so as not to cause dangerous reactions.
Third, the disposal of this chemical should not be ignored. Relevant regulations and standards should be strictly followed. It should not be dumped or discarded at will to prevent pollution of the environment. Generally speaking, it needs to be handed over to a professional recycling and disposal agency for disposal by specific methods to reduce the harm to the environment.
Fourth, before using this chemical, it is necessary to understand its physical and chemical properties, safety data and emergency treatment methods in detail. In the event of a leak or accident, emergency measures should be taken immediately, such as evacuating personnel, cutting off fire sources, ventilating, etc., and quickly report to relevant departments for professional rescue.
In short, when operating 2-propyl-1H-imidazole-4,5-dicarboxylate diethyl ester, it is necessary to attach great importance to safety issues, strictly abide by operating procedures and safety regulations, and take effective protection and emergency measures to ensure personal safety and environmental safety.