2-phenyl-1H-benzo[d]imidazole

2-Phenyl-1H-benzo [d] imidazole has a wide range of uses. In the field of medicine, it is often a key intermediate for the creation of drugs. Due to its specific chemical structure and biological activity, it can be modified to meet the treatment needs of different diseases. For example, in the development of anti-tumor drugs, by optimizing its structure, it may enhance the targeting and inhibitory effect on tumor cells; in the field of antibacterial drugs, it may use its unique activity to inhibit bacterial growth and reproduction.
In the field of materials science, 2-phenyl-1H-benzo [d] imidazole also plays an important role. It can be used as an organic optoelectronic material for devices such as Light Emitting Diode (LED) and organic solar cells. Due to its special electronic structure, it can effectively transfer charges and emit light, which helps to improve device performance and efficiency. In polymer materials, adding this substance can improve the thermal stability and mechanical properties of the material, and expand the application scenarios of polymer materials, such as the manufacture of high-performance engineering plastics.
Furthermore, in the field of analytical chemistry, 2-phenyl-1H-benzo [d] imidazole can be used as an analytical reagent. With its selective reaction or binding characteristics with specific substances, it can achieve accurate detection and identification of certain ions and molecules. In environmental monitoring, it can be used to detect specific pollutants; in biological analysis, it can help detect specific biomolecules in organisms, providing important information for disease diagnosis and treatment. In short, 2-phenyl-1H-benzo [d] imidazole has important uses in many fields and is of great significance to promote the development of related fields.

There are several common methods for the synthesis of 2-phenyl-1H-benzo [d] imidazole.
First, the synthesis method using o-phenylenediamine and benzoic acid as raw materials. Put o-phenylenediamine and benzoic acid in a reaction vessel in an appropriate ratio, add an appropriate amount of catalyst, such as zinc powder, copper oxide, etc. At high temperature, usually at 200-300 ℃, the condensation reaction is carried out. In this reaction process, the carboxyl group of benzoic acid and the amino group of o-phenylenediamine undergo dehydration and condensation, and gradually form a ring to obtain 2-phenyl-1H-benzo [d] imidazole. The advantage is that the raw materials are easy to obtain, but the reaction conditions are more severe, high temperature is required, and the yield is sometimes poor.
Second, the synthesis path of o-nitroaniline and benzonitrile. First, the reduction of o-nitroaniline to o-phenylenediamine, the commonly used reducing agents are iron filings, sodium sulfide, etc. Then, o-phenylenediamine and benzonitrile in suitable solvents, such as ethanol and dimethylformamide, at a certain temperature, about 100-150 ℃, and under the catalysis of bases, such as potassium carbonate and sodium hydroxide, cyclization occurs to form the target product. Although this method is a little more complicated, the yield is relatively high, and the reaction conditions are milder than the former.
Third, phthalic anhydride and aniline are used as starting materials. First, phthalic anhydride reacts with aniline to form an intermediate product. This reaction is carried out under the action of appropriate temperature and catalyst. Subsequently, the intermediate product is converted into 2-phenyl-1H-benzo [d] imidazole through dehydration, cyclization and other steps. This synthesis method has relatively many steps, but the reaction process and product purity can be adjusted according to different reaction conditions and catalysts.
The above synthesis methods have their own advantages and disadvantages. In practical application, the appropriate synthesis path needs to be carefully selected according to many factors such as the availability of raw materials, cost, yield and product purity.

2-Phenyl-1H-benzo [d] imidazole is an organic compound. It has unique physical properties and has been used in many fields.
Discussing the physical properties of this substance, first of all, its appearance is often solid, and the color is white to light yellow powder. This appearance makes it more convenient for storage and operation. Its melting point is quite high, about 280-285 ° C. High melting points, due to strong interaction forces between molecules, such as hydrogen bonds, van der Waals forces, etc., require higher temperatures to destroy this force and make it melt.
Furthermore, 2-phenyl-1H-benzo [d] imidazole has different solubility in organic solvents. In common organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), it has a certain solubility. However, in water, its solubility is very small. This difference in solubility is due to its molecular structure containing benzene rings and imidazole rings, which are hydrophobic groups. Therefore, it is difficult to dissolve in hydrophilic water and more soluble in organic solvents with certain polarity.
The density of this substance is also one of its physical properties, about 1.30 g/cm ³. This density value reflects the mass of its unit volume, and has reference value for its space occupied in practical applications and its proportion when mixed with other substances.
In addition, 2-phenyl-1H-benzo [d] imidazole has certain thermal stability. Within a certain temperature range, its chemical structure can remain stable without significant decomposition or chemical reaction. This thermal stability makes it possible to apply it in high temperature environments. For example, it can be used as an additive or a reaction intermediate during the preparation of materials under certain high temperature conditions.

2-Phenyl-1H-benzo [d] imidazole is an organic compound with unique chemical properties and is widely used in many fields.
This compound is white to pale yellow crystalline powder and is quite stable under conventional conditions. Its melting point is high, up to 270-272 ° C, due to strong interaction forces between molecules, such as hydrogen bonds and π - π accumulation.
2-phenyl-1H-benzo [d] imidazole is insoluble in water, but soluble in common organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc. This solubility characteristic makes it convenient to apply in organic synthesis and solution processing processes.
The compound contains a core structure of benzimidazole, and the fused benzene ring and imidazole ring endow it with significant aromaticity. The aromaticity results in excellent thermal and chemical stability of the compound, which can withstand high temperature and most chemical reaction conditions, and will not easily decompose or undergo structural changes.
From the perspective of electronic structure, the conjugated system of 2-phenyl-1H-benzo [d] imidazole is large and has a high degree of electron delocalization. This gives it unique optical and electrical properties. For example, it can fluoresce under specific wavelength light excitation, so it is widely used in the field of fluorescent materials, such as fluorescent probes and Light Emitting Diodes (LEDs).
In terms of chemical reactivity, the nitrogen atom on the imidazole ring of 2-phenyl-1H-benzo [d] imidazole has a lone pair electron, which is basic and can react with acids to form salts. At the same time, because of its conjugated structure, it can participate in nucleophilic substitution reactions as a nucleophilic reagent, or as a ligand to coordinate with metal ions to form metal complexes, which shows potential application in the field of catalysis.

The price range of 2-phenyl-1H-benzo [d] imidazole in the market is difficult to determine with certainty. The price of this compound often varies due to multiple factors, such as quality, supply and demand, difficulty in preparation, purchase quantity, and fluctuations in market conditions.
If its quality is high, and it meets the standard of high purity, it is suitable for precise scientific research or special industrial purposes, its price must be high. And if the quality is slightly inferior, only for general use, the price may be slightly lower.
On the supply and demand side, if there are many people who want it, and the supply is small, the price will be easy to rise; on the contrary, if the market supply is abundant and the demand is normal, the price may stabilize or even drop.
The difficulty of preparation is also the key. If the preparation requires complex processes and rare raw materials, the cost will be high, and the price will follow; if the preparation is relatively simple and the cost is controllable, the price may drop.
Purchase volume also has an impact. A large number of buyers often receive discounts due to scale effects, and the unit price is lower; small buyers pay a higher unit price each time.
As for the exact price range, it is difficult to hide it. However, you can find chemical raw material suppliers, reagent sales platforms, or consult industry insiders to obtain more accurate price information. Or on some chemical reagent e-commerce platforms, the price of common specification packaging may range from tens of yuan per gram to hundreds of yuan per gram, which is only approximate. The actual price is subject to real-time market conditions.