2-(p-Chlorobenzyl)benzimidazole

2-%28p-Chlorobenzyl%29benzimidazole is 2- (p-chlorobenzyl) benzimidazole, which has a wide range of uses.
In medicine, it is often the key raw material for the creation of insecticide-repellent drugs. Because of its structural characteristics, the cover can produce specific biological activities for parasitic organisms, such as intestinal nematodes, etc., which interfere with the physiological functions of the insect body and achieve the effect of deworming. In the chemical industry, it can be used as a monomer for the synthesis of special functional polymer materials. By polymerization, it is integrated into the polymer skeleton to give materials such as special optical, electrical or thermal properties to meet the special needs of electronics, optical instruments, etc. In the field of materials science, it can be used as a metal corrosion inhibitor. It interacts with the metal surface to form a protective film and retards the metal corrosion process, which is of great significance for the protection of metal materials. And because of its unique chemical structure and properties, it is often used as an important intermediate in organic synthesis chemistry, used to build more complex and special organic compounds, and to help the research and development of new drugs and new materials.

2-%28p-Chlorobenzyl%29benzimidazole is 2 - (p-chlorobenzyl) benzimidazole, and its synthesis method is as follows:
** Using o-phenylenediamine and p-chlorophenylacetic acid as raw materials **:
Put o-phenylenediamine and p-chlorophenylacetic acid in an appropriate proportion in the reaction kettle, add an appropriate amount of condensing agent, such as polyphosphoric acid. This condensing agent can promote the condensation reaction between the two, and raise the temperature to a certain range, usually between 150-200 ° C. During the reaction, the carboxyl group of p-chlorophenylacetic acid is dehydrated and condensed with an amino group of o-phenylenediamine, and then the intramolecular cyclization forms a benzimidazole ring, and finally generates 2 - (p-chlorobenzyl) benzimidaz After the reaction is completed, the product is precipitated by cooling, dilution with water, etc., and then the crude product is obtained through filtration, washing, drying and other steps. After that, it can be further purified by recrystallization and other methods.
* Using o-nitroaniline and p-chlorophenylacetonitrile as raw materials **:
First, the o-nitroaniline is reduced. Commonly used reducing agents such as iron powder and hydrochloric acid system, at a suitable temperature, the o-nitroaniline is reduced to o-phenylenediamine. After the separation of o-phenylenediamine, it is mixed with p-chlorophenylacetonitrile, and a suitable catalyst, such as potassium carbonate, is added. In a suitable solvent such as N, N-dimethylformamide (DMF), the reaction is The cyano group of p-chlorophenylacetonitrile reacts with the amino group of o-phenylenediamine. After a series of nucleophilic addition, cyclization and other processes, the target product 2 - (p-chlorobenzyl) benzimidazole is formed. After the reaction, the solvent is removed by vacuum distillation, and then extracted with a suitable organic solvent to remove impurities. Finally, the pure product is purified by column chromatography and other methods.
** Using o-phenylenediamine and p-chlorobenzyl chloride as raw materials **:
In an alkaline environment, the o-phenylenediamine is mixed with p-chlorobenzyl chloride in an organic solvent, such as toluene. Bases such as sodium hydroxide or potassium carbonate can promote the reaction. The chlorine atom of p-chlorobenzyl chloride has high activity, and can undergo nucleophilic substitution reaction with the amino group of o-phenylenediamine to form an intermediate. Then, under appropriate conditions, the intermediate is further cyclized to form 2- (p-chlorobenzyl) benzimidazole. After the reaction is completed, the base and salt are removed by washing with water, and the organic phase is dried and concentrated, and the pure product is obtained by means of crystallization or column chromatography.

2-% 28p-Chlorobenzyl%29benzimidazole is an organic compound. Its physicochemical properties are of great value for investigation.
In terms of physical properties, this compound is usually in a solid state. The determination of its melting point is very important in the identification and purity determination. However, the melting point value varies depending on the preparation method and purity, and generally falls within a certain range. Its appearance may be white to white-like powder, with fine texture, and its fine granular form can be seen under light.
As for chemical properties, the benzimidazole ring in 2-% 28p-Chlorobenzyl%29benzimidazole has certain aromatic properties and good chemical stability. The chlorine atom on its benzene ring can cause nucleophilic substitution reactions. Due to the electron-absorbing properties of chlorine atoms, the electron cloud density of the benzene ring can be reduced, making the benzyl carbon connected to it more vulnerable to attack by nucleophiles. At the same time, the nitrogen atom of the benzimidazole ring has a lone pair of electrons, which can participate in coordination reactions and form complexes with metal ions. This property may have potential applications in catalysis, materials science and other fields. And under suitable conditions, it may undergo cyclization, addition and other reactions, showing rich chemical reactivity and providing diverse possibilities for organic synthesis chemistry. This compound is often used as an important intermediate in the field of organic synthesis. Through the rational application of its chemical properties, many organic compounds with special functions and structures can be prepared.

There is a definite price of 2 - (p-chlorobenzyl) benzimidazole in the market. This drug may be rare or rare in the market, but its price may be different from that of ordinary products due to its use or difficulty in preparation.
If you want to know its price, you should check it carefully in the market. Those in the market, or where there are pharmaceuticals or chemical products for sale, can ask. Or ask for it on various chemical trading platforms and pharmaceutical raw material websites. Such platforms often list the prices of various products, or you can get something.
However, its price also changes due to many reasons. The quality of its quality will affect its price. The price of the excellent product is high, and the price of the second is low. In addition to the situation of supply and demand, if there are many applicants and few suppliers, the price must rise; if the supply exceeds the demand, the price may drop. Furthermore, the difficulty of preparation and the cost are also related to the price. If the preparation is complex and the cost is high, the price is not cheap; if the preparation is easy and the cost is low, the price may be close to the people.
Although I cannot clarify the exact price, you can follow the above method and ask for it in the market, and you must get an approximate price.

2 -% 28p - Chlorobenzyl%29benzimidazole is 2 - (p-chlorobenzyl) benzimidazole. There are many things to pay attention to during the use of this substance.
First, it is related to safe operation. This compound may be toxic and irritating. When operating, you must wear suitable protective equipment, such as gloves, goggles and laboratory clothes, to prevent contact with the skin and eyes, and the operation should be in a well-ventilated environment, preferably in a fume hood to avoid inhalation of its dust or volatile gaseous substances, causing damage to the body.
Second, it involves storage methods. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources, because it may be flammable. If it is not stored properly, it will encounter open flames and hot topics, which may cause fire risk. At the same time, it should be stored separately from oxidizing agents to prevent chemical reactions, deterioration of substances or danger.
Third, when taking it, weigh it accurately. According to the amount required for experiment or production, measure it with an accurate weighing instrument to ensure the accuracy of reaction or production, and avoid waste. After weighing, seal the container in time to prevent it from deteriorating in contact with air, moisture, etc.
Fourth, during use, the reaction conditions need to be strictly controlled. Temperature, pH, reaction time, etc., all have a significant impact on the reaction of 2 - (p-chlorobenzyl) benzimidazole. If the temperature is too high or too low, or the reaction rate is abnormal, the product is impure or the yield is low; if the pH is not suitable, the reaction may not proceed as expected. Therefore, the reaction conditions should be carefully adjusted according to the reaction mechanism and past experience.
Fifth, after use, the treatment of waste should not be ignored. It cannot be discarded at will, and it needs to be properly disposed of in accordance with relevant environmental protection regulations. Or collect it in a centralized manner and hand it over to a professional treatment agency to prevent pollution to the environment.