2 Methylbenzimidazole
quinoline thiophene imidazole thiazole

2-Methylbenzimidazole

    Specifications

    HS Code

    627874

    Name 2-Methylbenzimidazole
    Molecular Formula C8H8N2
    Molar Mass 132.16 g/mol
    Appearance White to off - white solid
    Melting Point 176 - 178 °C
    Boiling Point 360 °C
    Solubility In Water Slightly soluble
    Solubility In Organic Solvents Soluble in ethanol, acetone, etc.
    Odor Odorless
    Pka 4.84 (protonated form)
    Density 1.22 g/cm³

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    General Information
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    Frequently Asked Questions

    As a leading 2-Methylbenzimidazole supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-methylbenzimidazole?
    2-% methylindolopyrazolone, this is a unique chemical substance. It has many main uses and is often a key raw material for the creation of new drugs in the field of medicine. The research and development of drugs requires the search for molecular structures with specific biological activities. The unique chemical structure of 2-% methylindolopyrazolone can interact with specific targets in organisms, or can regulate physiological processes, which is beneficial for the treatment of diseases.
    In the field of materials science, it has also attracted much attention. It may be used to prepare functional materials with special properties, such as optoelectronic materials. Due to the electronic structure properties of this substance, it may exhibit unique photoelectric effects under photoexcitation, providing the possibility for the development of new optoelectronic devices, such as organic Light Emitting Diodes, solar cells, etc., which are expected to improve the performance of the device.
    In the field of organic synthetic chemistry, 2-% methylindole-pyrazolone is an important synthetic intermediate. Chemists can chemically modify it to derive a variety of compounds with diverse structures, greatly enriching the types of organic compounds, laying the foundation for further exploration of new reactions and new properties.
    Although "Tiangong Kaiwu" does not contain this material, in ancient Chinese, this 2-% methylindole-pyrazolone has a wide range of uses. It can be used in medicine to help treat diseases, in materials to create strange materials, and in synthesis. It is the foundation for starting, introducing new paths in chemistry and promoting the progress of science and technology. Its power cannot be underestimated.
    What are the physical properties of 2-methylbenzimidazole?
    2-% methylpyridinoindole bases are a class of unique organic compounds. Their physical properties are rich and diverse, so let me tell you one by one.
    Looking at their appearance, they are often crystalline solids, pure in color, or white or yellowish, with regular crystal structure, or crystal clear in light. This appearance characteristic not only reflects the order of their internal structure, but also provides a visual basis for their use in various applications.
    When it comes to melting point, 2-% methylpyridinoindole base has a specific melting point range. Accurate determination of melting point can be used as an important indicator to identify its purity and characteristics. Different preparation methods and purity of this substance may have slight differences in melting point, but they are all within a certain reasonable range. This property is of great significance in separation, purification and quality control.
    Solubility is also a key physical property. In common organic solvents, such as ethanol, chloroform, etc., 2-% methylpyridine-indole base exhibits a certain solubility. Moderate solubility makes it convenient to participate in various solution chemical reactions, laying the foundation for the synthesis of more complex compounds. In water, its solubility is relatively limited, and this property determines its application tendency in aqueous and organic phase systems.
    Furthermore, the density of this substance also has characteristics. Although the density value fluctuates slightly according to specific conditions, the whole is within a specific range. This physical quantity provides key data support in practical application scenarios involving volume and mass conversion, such as preparation, measurement of reaction materials, etc.
    In addition, 2-% methylpyridyl-indole base may have unique optical properties under specific wavelengths of light. Such as absorbing specific frequencies of light, causing solutions or crystals to exhibit specific colors, or emitting specific wavelengths of fluorescence in fluorescence detection. This optical property opens the door for its application in cutting-edge fields such as analytical detection and biological imaging. With its sensitive response to optical signals, it can achieve accurate detection and localization of the substance in complex systems.
    What are the chemical properties of 2-methylbenzimidazole?
    2-% methylpyridyl-pyrazine, this is an organic compound. Its chemical properties are unique and have many characteristics.
    From the structural point of view, 2-% methylpyridyl-pyrazine contains a cyclic structure fused with pyrazine. This special structure endows it with certain stability and unique electron cloud distribution, which affects its reactivity.
    In terms of physical properties, its appearance is often solid, and its melting point, boiling point and other properties are affected by intermolecular forces. Because the molecule contains nitrogen heterocycles, it can form hydrogen bonds, which may affect the melting point, solubility, etc. Generally, it is more soluble in organic solvents or better than water, because the molecule has certain hydrophobicity.
    Chemically, the nitrogen atom of 2% methylpyridine-pyrazine is rich in solitary pairs of electrons and has a certain alkalinity, which can react with acids to form salts. At the same time, due to the existence of its conjugate system, it can participate in electrophilic substitution reactions. Under appropriate conditions, methyl groups can also undergo related reactions, such as oxidation reactions, and convert into other functional groups such as carboxyl groups. Its nitrogen heterocyclic part can also participate in various cyclization reactions, addition reactions, etc., which is of great value in the field of organic synthesis. It can be used as a key intermediate for the preparation of many compounds with biological activity or special functions. Under specific conditions, metal-catalyzed reactions can also occur to achieve functional group modification and expand its application in organic synthesis chemistry.
    What are the synthesis methods of 2-methylbenzimidazole?
    There are many ways to synthesize 2-% methylpyridine and indole compounds. The first method is to use o-halopyridine and indole derivatives as starting materials, and in the presence of alkali and metal catalysts, the coupling reaction is carried out. If potassium carbonate is used as a base, a palladium-based catalyst is assisted to make the two in a suitable solvent and refluxed by heating to form this compound. This reaction condition is mild and the yield is good. However, the cost of the catalyst is slightly higher, and the post-processing may be slightly cumbersome.
    Both are prepared by intramolecular cyclization. First, a precursor with a specific structure is prepared, which contains pyridine and indole structural fragments and is connected with a suitable chain segment. Under the catalysis of acid or base, the intramolecular cyclization occurs to construct the target pyridine and indole structure. When catalyzed by acid, Lewis acids such as aluminum trichloride are commonly used, and strong bases such as sodium alcohol are used for alkali catalysis. This approach has high atomic economy, but the preparation of precursors may require multiple steps and the route is slightly longer.
    Three, with the help of C-H activation strategy catalyzed by transition metals. Under the catalysis of transition metals such as rhodium and ruthenium, the C-H bond at a specific position is selectively activated to make it coupling and cyclized. This method is simple in steps, green and efficient, but the control of reaction conditions is strict, the catalyst is also expensive, and the selective regulation is sometimes difficult.
    Four, the core structure can be constructed by multi-step reaction from simple raw materials. Pyridine fragment and indole fragment are synthesized first, and then spliced together by suitable reaction, and then the target product is modified by cyclization. This method is flexible, and various substituents can be introduced according to demand, but the synthesis route is lengthy, the total yield may be affected, and each step of the reaction needs to be carefully controlled. All synthetic methods have their own advantages and disadvantages, and the application needs to be selected according to the actual needs and conditions.
    What is the price range of 2-methylbenzimidazole in the market?
    In today's market, the price of dimethylpyridine-pyrazine varies according to the quality, quantity, and supply and demand. The better one, the price must be higher; if the quality is slightly inferior, the price may be slightly reduced.
    If you talk about the approximate price, it is usually between tens of dollars and hundreds of dollars per catty. However, this is not a fixed number, and the market conditions are constantly changing. The abundance of production and the urgency of use can make the price rise and fall. When it is used in abundance, the price will decline; if the production is small and the demand is large, the price will rise.
    And in different places, the price also varies. In the capital city, merchants converge, goods are easy to circulate, and the price may be relatively flat; in remote places, transshipment is difficult, and the price may be slightly higher. There are also those who are measured in quantity, and the purchase quantity is huge, and the merchant may have a discount, and the price may be slightly reduced. If you want to know the exact price, you can only get the actual price when you ask the market in detail, depending on the time and place.