2-methyl-1-(methylsulfonyl)-1H-benzolimidazole

2-Methyl-1- (methylsulfonyl) -1H-benzimidazole This substance has unique chemical properties. Its structure contains benzimidazole parent nucleus, methyl at 2 positions, and methyl sulfonyl at 1 position. This specific structure gives it a variety of chemical activities.
From the perspective of physical properties, it is mostly in a stable solid state at room temperature. Due to intermolecular forces, it has a certain melting point and boiling point, but the exact value is subject to purity and measurement conditions. And because it contains polar group methylsulfonyl, it has a certain solubility in polar solvents such as alcohols and ketones, but poor solubility in non-polar solvents.
When it comes to chemical activity, the benzimidazole ring has electron-rich properties and is prone to electrophilic substitution reactions, such as halogenation, nitrification, etc. New groups can be introduced into the benzimidazole ring to derive a variety of compounds. The sulfur atom in the methyl sulfonyl group is in a high valence state and is oxidizing, which can participate in the redox reaction. At the same time, the nitrogen atom contains lone pair electrons, which can be used as a ligand to complex with metal ions to form metal complexes, which has potential applications in the fields of catalysis and materials science.
In addition, although the methyl group of the compound is relatively stable, it can undergo oxidation or substitution reactions under specific conditions, such as strong oxidants or high temperatures, expanding its reaction path and product types, providing a broad space for the research and application of organic

2-Methyl-1- (methylsulfonyl) -1H-benzimidazole is an organic compound that has its common uses in many fields.
In the field of medicinal chemistry, such compounds often have potential biological activities or can be used as lead compounds for the development of new drugs. Due to their specific chemical structure, they can interact with specific targets in organisms, such as certain enzymes or receptors. Taking a study as an example, modified compounds containing this structure show inhibitory effects on the growth of specific cancer cells and are expected to be developed as anticancer drugs.
In the field of materials science, it may be used to prepare functional materials. Due to the specific electronic properties and stability of the compound, it can participate in the synthesis of polymer materials with special properties. If it undergoes a specific polymerization reaction, it may endow the material with unique electrical and optical properties, which can be used to make optoelectronic materials, such as organic Light Emitting Diode (OLED) related materials, to improve device performance.
In agricultural chemistry, or can be used as a pesticide intermediate. By reacting with other chemical substances, pesticides with insecticidal, bactericidal or herbicidal activities can be synthesized. Its structure can endow pesticides with better stability and biological activity, enhance the effect of pesticides on pest control, and reduce adverse effects on the environment, achieving the purpose of high-efficiency and low-toxicity pesticide research and development. Due to its unique structure, this compound is widely used in the fields of medicine, materials, agriculture, etc. With the development of science and technology, its potential applications may continue to expand.

To prepare 2-methyl-1- (methylsulfonyl) -1H-benzimidazole, the method is as follows:
First take an appropriate amount of o-phenylenediamine and place it in a clean reactor. Alcohols are used as solvents, often ethanol, because of their good solubility and mild properties, which is convenient for the reaction. When stirring, slowly add an appropriate amount of formic acid. The amount of formic acid needs to be precisely controlled, and the amount of o-phenylenediamine should be added in a specific ratio. Generally speaking, the ratio of the two substances is about 1.2:1. This ratio can promote the smooth progress of the reaction in the direction of generating 2-methylbenzimidazole. Heat up to 60-80 ° C. This temperature range allows the reaction to occur smoothly and avoids excessive side reactions. When the reaction is continuously stirred for several times, about 3-5 hours, after the reaction solution cools, precipitation precipitates out. Collect the precipitate by filtration, wash it with an appropriate amount of cold water, remove impurities, and then dry to obtain 2-methylbenzimidazole.
Take the resulting 2-methylbenzimidazole, place it in another reaction vessel, add an appropriate organic solvent, such as dichloromethane, which has good solubility to the reactants and is conducive to uniform reaction. Under low temperature cooling conditions, usually 0-5 ° C, slowly add methylsulfonyl chloride dropwise. The amount of methyl sulfonyl chloride and 2-methylbenzimidazole should also follow a certain ratio, about 1.1:1. The dropwise addition process must be slow to prevent the reaction from being too violent. After the dropwise addition is completed, heat up to room temperature and continue to stir the reaction for 6-8 hours. After the reaction is completed, pour the reaction solution into an appropriate amount of water, and there is a layering phenomenon. Take the organic phase and dry it with anhydrous sodium sulfate to remove water. After vacuum distillation, the organic solvent was removed, and the residue was separated and purified by column chromatography. Petroleum ether and ethyl acetate were used as eluents in an appropriate ratio (such as 3:1) to collect the eluent containing the target product, and the solvent was evaporated to obtain pure 2-methyl-1- (methyl sulfonyl) -1H-benzimidazole. The whole process needs to pay attention to the precise control of reaction conditions and careful operation in each step to obtain satisfactory yield and purity.

The price of 2-methyl-1- (methylsulfonyl) -1H-benzimidazole in Wuwei City. However, if you want to push the range of its price, you can do it according to various reasons.
View this compound, a benzimidazole derivative, may have its use in medicine, chemical industry and other fields. If it is used in pharmaceutical research and development, it has the ability to affinity and regulation to specific targets, or it is involved in the creation of new drugs, and the demand or price are different.
In chemical synthesis, if it is an important intermediate, its synthesis is difficult and related to the price. The synthesis path of this substance is complex, the raw materials are rare and expensive, and the steps are often costly. If the extraction and purification of raw materials requires fine processes, the price will increase if it consumes more.
Furthermore, the market supply and demand situation is also heavy. If there are many people who want it, the production will be few, and the price will rise; if there is excess capacity, the demand will be thin, and the price will be depressed.
Also known as its purity, high purity is used in high-end fields such as medicine and electronics, with strict preparation and high price; slightly lower purity is used in general chemical industry, and the price is low.
With common sense, if it is used in a small amount in the laboratory and the purity is high, the price per gram may reach hundreds of gold; if it is produced in large quantities in industry, the demand is large, and the purity is moderate, and the price per ton may be tens of thousands of gold to hundreds of thousands of gold. However, this is all speculation, and the actual price must be determined according to market conditions, manufacturers, and various factors at the time of transaction.

2-Methyl-1- (methylsulfonyl) -1H-benzimidazole is an organic compound. Its safety is related to many aspects and needs to be carefully observed.
When it comes to toxicity, although there is no conclusive large-scale toxicity data for all humans, in animal experiments, if the dose is too high, adverse reactions may be seen. If it has a certain burden on the liver, kidneys and other organs, it may lead to changes in biochemical indicators and cause abnormal organ function. This warning warns us to limit the dose strictly to avoid excessive exposure.
Let's talk about its environmental impact again. If it flows into the environment, its chemical structure has a certain stability, or it is difficult to degrade quickly. Accumulate in water and soil, or affect the ecosystem. For aquatic organisms, or cause their growth and reproduction to be blocked; in the soil microbial community, or break its balance, and then affect the growth of vegetation. Therefore, when producing and using, it is necessary to deal with waste and prevent its wanton discharge.
When operating, protection is extremely important. Experimenters need to wear protective clothing, which can avoid contact with the skin and prevent skin allergies and irritation. Also wear protective gloves, the material must be resistant to corrosion. Eye protection should also not be ignored. Wear goggles to prevent it from splashing into the eyes and damaging the eye tissue. Operate in a well-ventilated place, if in a confined space, it will evaporate gas, or cause respiratory irritation, or even poisoning.
In terms of storage, it should be stored in a cool and dry place, protected from heat and moisture. Due to its chemical properties, it is inappropriate to co-store with strong oxidants, strong acids, strong bases, etc., to prevent violent reactions and cause safety risks. And the storage place should be clearly marked to indicate its characteristics and hazards.
2-methyl-1- (methylsulfonyl) -1H-benzimidazole safety, toxicity, environmental impact, operation and storage, all need to be cautious, and follow safety procedures to avoid risks.