2 Hydroxymethylbenzimidazole
quinoline thiophene imidazole thiazole

2-Hydroxymethylbenzimidazole

    Specifications

    HS Code

    311087

    Chemical Formula C8H8N2O
    Molecular Weight 148.16 g/mol
    Appearance White to off - white solid
    Melting Point 178 - 182 °C
    Solubility In Water Slightly soluble
    Solubility In Organic Solvents Soluble in some organic solvents like ethanol, DMSO
    Pka Value Approximately 13 (estimation for the phenolic - like OH group)
    Odor Odorless or very faint odor
    Density 1.32 g/cm³ (estimated)
    Stability Stable under normal conditions, but may react with strong oxidizing agents

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    General Information
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    Frequently Asked Questions

    As a leading 2-Hydroxymethylbenzimidazole supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-hydroxymethylbenzimidazole?
    The main uses of 2-% fluoromethylpyridopyrazolomide are as follows:
    This drug is often used as a key raw material for the creation of new drugs in the field of medicine. Its unique chemical structure endows the drug with diverse biological activities. For example, by modifying its structure, drugs with high antibacterial properties can be developed. Bacterial cell wall synthesis, protein synthesis and other key physiological processes can be interfered by drugs containing this ingredient, thereby inhibiting bacterial growth and reproduction, providing a powerful means for the treatment of bacterial infections such as pneumonia and sepsis.
    In the agricultural field, 2-% fluoromethylpyridopyrazolomide is often used as an active ingredient in pesticides. It can play a significant role in repelling and poisoning against a variety of pests. Physiological functions such as the nervous system and digestive system of pests will be damaged by it, such as interfering with the transmission of neurotransmitters in pests, causing them to move disordered, blocked eating, and eventually die. It can effectively prevent and control aphids, borers and other crop pests, ensure crop yield and quality, reduce the application of chemical pesticides, and help the sustainable development of agriculture.
    In addition, it has also emerged in the field of materials science. Due to its special chemical properties, it can be used to synthesize polymer materials with special properties. After a specific reaction, it is introduced into the main chain or side chain of the polymer, so that the material has unique electrical, optical or thermal properties, expanding new directions for the research and development of new materials, and has potential application value in electronic devices, optical instruments and other fields.
    What are the synthesis methods of 2-hydroxymethylbenzimidazole?
    2-% pentylbenzoic acid and thiazole are important compounds in the field of organic synthesis. There are many synthesis methods. Several common ones are described in detail below:
    1. ** Using benzoic acid as the starting material **: Benzoic acid is halogenated by introducing halogen atoms at specific positions in the benzene ring. Bromine or chlorine are commonly used. Under the catalysis of appropriate catalysts such as iron powder, halogenated benzoic acid can be formed. After that, halogenated benzoic acid undergoes a substitution reaction with a reagent containing an amyl group, and the amyl group replaces the halogen atom. The amyl group can be selected as a halide or amyl alcohol, etc., and is carried out in basic conditions and suitable solvents. The obtained pentylbenzoic acid reacts with reagents containing thiazole structure to construct a thiazole ring. Common thiazole synthesis reagents participate in the reaction, and finally obtain 2-% pentylbenzoic acid thiazole after multi-step reaction. The raw materials for this route are easy to obtain, and the reaction conditions of each step are relatively mild, which is conducive to operation and control.
    2. ** Using thiazole derivatives as starting materials **: Select suitable thiazole derivatives and modify them. The carboxyl group is first introduced, and the suitable substituent group on the thiazole ring can be converted into a carboxyl group through a specific oxidation reaction. Then through esterification reaction, the carboxyl group is converted into an ester group that is easy to further react, and a specific alcohol is reacted with it. Subsequently, the ester group reacts with the amyl-containing reagent, and the amyl group is connected to the carboxyl ester of the thiazole ring, and the amylation reagent is selected according to the reaction conditions and needs. Finally, through hydrolysis and other reactions, the ester group is restored to the carboxyl group, and the synthesis of 2-% amylbenzoic acid and thiazole is achieved. This approach focuses on the modification of thiazole rings, and requires higher selection and reaction conditions for thiazole derivatives, but it has unique advantages for the construction of specific structure and thiazole rings.
    3. ** Adopts a cyclization reaction strategy **: Select compounds containing amyl groups, carboxyl groups, and related atomic groups constructed with thiazole rings. Under suitable catalysts and reaction conditions, these compounds undergo intramolecular cyclization reactions. If it contains specific unsaturated bonds and heteroatom compounds, under the action of catalysts, the unsaturated bonds migrate, rearrange, and interact with heteroatoms to build a thiazole ring and form the parent structure of benzoic acid and thiazole, while the amyl and carboxyl groups remain in the appropriate position to obtain the target product 2-% pentylbenzoic acid and thiazole. This method builds a complex ring system in one step, with high atomic economy, but the reaction conditions are harsh and the substrate structure is strict.
    What are the physical and chemical properties of 2-hydroxymethylbenzimidazole?
    The physical and chemical properties of 2-% fluoromethyl indole-pyrrolizine are related to its physical state, solubility, stability, etc. This substance may be in a solid state at room temperature due to the intermolecular forces. Its crystal structure is tightly ordered, resulting in a certain hardness and shape.
    In terms of solubility, it may have a certain solubility in organic solvents such as dichloromethane, N, N-dimethylformamide. This is because the molecules of this substance can interact with organic solvent molecules by van der Waals force, hydrogen bonds, etc., so that the molecules are uniformly dispersed. However, in water, the solubility may be very small, because the polarity of the molecule is quite different from that of water, and the hydrogen bond network of water is difficult to accept the molecule.
    In terms of stability, 2 -% fluoromethyl indole-pyrrolizine is relatively stable under normal conditions. Among its molecular structures, the indole-pyrrolizine skeleton is relatively rigid, and the introduction of fluoromethyl has an impact on the distribution of electron clouds, but it does not cause the molecule to be too active. However, under extreme conditions such as high temperature, strong oxidants or strong bases, its structure may change. At high temperatures, the thermal motion of molecules intensifies, the vibration of chemical bonds is enhanced, or the bonds are broken; strong oxidants can capture their electrons, initiate oxidation reactions, and change the molecular structure; strong bases may react with reactive groups in the molecule, such as acidic hydrogen, resulting in structural changes.
    In addition, the melting point and boiling point of the substance are also important physical properties. The melting point varies depending on the strength of the intermolecular force, and the melting point is higher when the force is strong. The same is true for the boiling point, which reflects the energy required to transform from liquid to gas, which is related to the intermolecular force and molecular weight. Its spectral properties, such as infrared spectroscopy and nuclear magnetic resonance spectroscopy, can help analyze its molecular structure. Each absorption peak in the infrared spectrum corresponds to the vibration of different chemical bonds. Nuclear magnetic resonance spectroscopy reveals the chemical environment of hydrogen, carbon and other nuclei in the molecule, making it a powerful tool for studying its physical and chemical properties.
    What is the price of 2-hydroxymethylbenzimidazole in the market?
    Since modern times, the price of 2-fluoromethylpyridine-thiazole has been inquired by merchants in the market. This substance is widely used in medicine and agrochemical, so its price is also important in various industries.
    The price of 2-fluoromethylpyridine-thiazole often fluctuates due to various reasons. First, the price of raw materials has a deep impact. If the price of all raw materials required for its preparation is high and rare, the price of this product will also rise. On the contrary, if the raw materials are abundant and cheap, the price of the product may be low. < Br >
    Second, the craftsmanship is also related to its price. Fine craftsmanship can increase the yield, reduce the cost, and the price will stabilize or drop slightly. If the process is difficult, the yield is low, and the cost is wasted, the price will be difficult to level.
    Third, the supply and demand of the market is the key to the price. If there are many people who want it, and there are few people who supply it, the price will rise; if the supply exceeds the demand and the stock is difficult to sell, the price will be in danger of falling.
    At the moment, the price of 2-fluoromethylpyridinothiazole in the market is about [X] to [X]. However, this is only the current price, the market conditions are ever-changing, the situation is unpredictable, and its price may vary from time to time. When the industry assesses the situation, observes the market of raw materials, studies the progress of technology, and observes the ups and downs of supply and demand, it is possible to gain insight into the changes in their prices in the business sea, and make profits and avoid risks.
    What are the relevant derivatives of 2-hydroxymethylbenzimidazole?
    2-%E7%BE%9F%E7%94%B2%E5%9F%BA%E8%8B%AF%E5%B9%B6%E5%92%AA%E5%94%91%E4%B8%8E%E5%A4%9A%E7%A7%8D%E8%A1%8D%E7%94%9F%E7%89%A9%E7%9B%B8%E5%85%B3. The following is the description of various related things:
    Ginseng is the first to introduce it. It is a precious Chinese medicinal material. It has the effect of nourishing vitality, restoring veins and solidifying removal, nourishing spleen and lungs, nourishing body and blood, calming the nerves and nourishing intelligence. In traditional medical concepts, ginseng can greatly replenish human qi and blood, and help the weak to restore vitality. Its growth environment is harsh, and it is mostly born in deciduous broad-leaved forests or coniferous broad-leaved mixed forests hundreds of meters above sea level. The long growth cycle makes it very precious.
    Polygonum multiflorum is also closely related. This medicine can replenish liver and kidney, nourish sperm and blood, black whiskers, strengthen muscles and bones, and reduce turbidity and lipid. Its roots are thick and have a long history of being used in medicine. Legend has it that Polygonum multiflorum can turn white hair to black. Although it is suspected of being exaggerated, its ability to nourish liver and kidney, improve sperm and blood has been widely recognized.
    Rehmannia Rehmannia is also an important related thing. Fresh Rehmannia clears heat and generates fluid, cools blood and stops bleeding; Rehmannia Rehmannia clears heat and cools blood, nourishes yin and generates fluid; Rehmannia Rehmannia nourishes yin and nourishes blood, and nourishes essence and fills marrow. Rehmannia Rehmannia Rehmannia has its own emphasis on medicinal effects under different processing states, and is quite effective in regulating various diseases of yin deficiency and blood deficiency in the human body.
    Rehmannia Rehmannia can also not be ignored. Rehmannia Rehmannia returns to the spleen, lungs and kidney meridians, and has the effects of nourishing qi and Its appearance is like tender ginger, sweet taste, can be used for both medicine and food, long-term use has the reputation of lightness and longevity, and has a good effect on lung deficiency and dry cough, weakness of spleen and stomach, kidney deficiency and essence deficiency.
    Lycium barbarum seeds also belong to this category. It nourishes liver and kidney, improves essence and eyesight, is rich in a variety of nutrients, regular food can improve human immunity, improve waist and knee soreness, dizziness, vision loss and other diseases caused by liver and kidney yin deficiency, and is easy to eat. It can be chewed directly, or soaked in water and soup.
    All of the above are common supplements or organisms related to 2-methylaminobenzoic acid and pyridine. It has a long-standing reputation in the field of traditional medical health and treatment, and is of great significance to human health maintenance and disease treatment.