2-(Chloromethyl)-1H-Benzo[D]Imidazole-6-Carbonitrile

2-%28Chloromethyl%29-1H-Benzo%5BD%5DImidazole-6-Carbonitrile, Chinese name 2- (chloromethyl) -1H-benzo [D] imidazole-6-formonitrile, this compound has a wide range of uses.
In the field of medicinal chemistry, it is often used as a key intermediate. In the development process of many new drugs, due to their unique structures, they can be spliced with other molecules through various chemical reactions to shape novel structures with specific biological activities. For example, in the creation of anti-tumor drugs, this is used as a starting material to synthesize compounds with targeted inhibitory effects on tumor cells through modification and derivatization. Studies have shown that some compounds derived from this structure exhibit excellent inhibitory activity on specific tumor cell lines, providing new opportunities for the development of anti-tumor drugs. < Br >
In the field of materials science, it also has important applications. Because it contains specific functional groups, it can participate in the synthesis of polymer materials. It can be used as a crosslinking agent or functional monomer to introduce polymer systems and endow materials with new properties. For example, the preparation of functional polymer materials with special optical and electrical properties, the improvement of mechanical properties and thermal stability of materials, etc., has potential application prospects in photoelectric materials, sensor materials, etc.
In the field of organic synthetic chemistry, it is an important synthetic building block. Organic chemists use its chloromethyl and nitrile groups to carry out various classical organic reactions, such as nucleophilic substitution reactions, cyclization reactions, etc., to construct complex organic molecular structures, enrich the variety of organic compounds, and contribute to the development of organic synthetic chemistry.

2-%28Chloromethyl%29-1H-Benzo%5BD%5DImidazole-6-Carbonitrile is 2 - (chloromethyl) -1H - benzo [d] imidazole - 6 - formonitrile, and its synthesis method is as follows:
Suitable benzimidazole derivatives can be selected as starting materials. If 6 - amino benzimidazole is used as the starting material, the amino group is first protected to prevent its interference in subsequent reactions. Protective groups such as acetyl can be selected, and the amino group is acetylated by reacting with acetyl chloride in the presence of a suitable base (such as pyridine).
Subsequently, chloromethyl is introduced at the 2 - position of benzimidazole. This step often uses chloromethylation reagents, such as chloromethyl methyl ether (need to be handled with care, because it is carcinogenic), and reacts under the catalysis of Lewis acid (such as ZnCl ²). The reaction system is maintained at an appropriate temperature, such as 40-60 ° C, so that the 2-position of benzimidazole is electrophilically substituted, and chloromethyl is introduced.
Next, remove the protective group on the amino group. If acetyl protection is used, the amino group can be hydrolyzed under acidic conditions (such as dilute hydrochloric acid) to restore the amino group.
Finally, the amino group is converted to a cyano group. The commonly used method is to react with sodium nitrite in an acidic (such as hydrochloric acid) environment to form a diazonium salt. The diazonium salt is then reacted with cyanide reagents such as cuprous cyanide (CuCN), and the diazonium group is replaced by a cyanide group to obtain 2- (chloromethyl) -1H-benzo [d] imidazole-6-formonitrile.
The whole synthesis process requires strict control of the reaction conditions, including temperature, pH and ratio of reactants, and the separation and purification of intermediates to ensure the purity and yield of the final product.

2-%28Chloromethyl%29-1H-Benzo%5BD%5DImidazole-6-Carbonitrile, Chinese name 2- (chloromethyl) -1H-benzo [d] imidazole-6-formonitrile, this is an organic compound. Its physical and chemical properties are as follows:
Appearance properties, normal or white to light yellow crystalline powder, fine texture, this form is quite common in many organic synthesis products, because of its molecular structure arrangement and interaction, resulting in its solid state characteristics.
Melting point, about 180 - 185 ℃, the melting point range is an important physical sign of this compound, determined by the intermolecular force and lattice energy. At a specific temperature, the lattice is destroyed, and the molecule obtains enough energy to break free from bondage and turn from solid to liquid. In terms of solubility, it is slightly soluble in water, but soluble in common organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc. This is because water is a polar solvent, and the molecular polarity of the compound is limited, and the interaction with water is weak; the polarity of the organic solvent is adapted to the molecular structure, and it can form a good interaction with the compound, resulting in its solubility.
Stability level, stable at room temperature and pressure. When encountering strong oxidizing agents, strong acids, and strong bases, or initiating chemical reactions. Because strong oxidizing agents can seize their electrons, strong acids and strong bases can react with active groups, affecting the integrity of molecular structures. Chloromethyl chloride has high reactivity and is prone to nucleophilic substitution reactions. It can react with nucleophilic reagents containing nitrogen, oxygen, sulfur, etc., to generate compounds with diverse structures, which is of great significance in the field of organic synthesis. It can be used to construct complex molecular structures, synthesize organic materials with special functions, drug intermediates, etc. Benzimidazole rings are also reactive and can participate in a variety of cyclization and substitution reactions, providing multiple pathways for organic synthesis.

I think what you are asking is about the market price range of 2- (chloromethyl) -1H-benzo [D] imidazole-6-formonitrile. However, the price of this product is difficult to determine. The price often changes due to many factors, such as the abundance of raw materials, the difficulty of preparation, the amount of demand, and the competitive situation of the market.
If the raw materials are abundant and easy to obtain, and the preparation method is simple, the price may be slightly lower; conversely, if the raw materials are rare and complicated to prepare, the price will rise. The increase or decrease in demand is also the key. If the demand is strong, the price may increase; if the demand is weak, the price may decrease.
And whether the market competition is fierce or not also affects its price. Competition is fierce, merchants compete for market share, or reduce prices to promote sales; competition eases, and prices may stabilize.
Therefore, in order to know the exact price range, it is necessary to carefully investigate the market dynamics of chemical raw materials, consult merchants and traders specializing in this chemical, or refer to the data of the chemical product price information platform, in order to obtain a more accurate price. As far as I know, it is difficult to tell you the specific price range directly.

Today there is a question about the manufacturer of 2- (chloromethyl) -1H-benzo [D] imidazole-6-formonitrile. This compound may have important uses in chemical, pharmaceutical and other fields. To know its manufacturer, you need to visit many books and information to know it.
In today's world, the chemical industry is prosperous, and manufacturers are scattered all over the place. It is not easy to know the manufacturer of 2- (chloromethyl) -1H-benzo [D] imidazole-6-formonitrile accurately. Because there are many chemical products, each manufacturer also has its own emphasis.
There may be professional chemical directories and industry reports, which may contain information on relevant manufacturers. Or you can explore its whereabouts on chemical trading platforms and industry exhibitions. Many large chemical companies may be involved in the production of this compound. However, the specific name needs to be checked in detail in chemical information, industry exchange forums, etc., in order to obtain it.
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