2-CHLORO-5-NITRO-1H-IMIDAZOLE

2-Chloro-5-nitro-1H-imidazole, this is an organic compound. It has a wide range of uses in the field of medicine, and is mostly a key intermediate of antibacterial drugs. For example, some nitroimidazole antibacterial drugs, 2-chloro-5-nitro-1H-imidazole plays an indispensable role in the synthesis process. Such antibacterial drugs have good inhibitory and killing effects on anaerobic bacteria, trichomonas and other pathogens, so they are often used to treat infections caused by the above pathogens.
In the field of pesticides, 2-chloro-5-nitro-1H-imidazole is also used. It can be used as a raw material for the synthesis of certain pesticides. The prepared pesticides have insecticidal and bactericidal properties, which can effectively protect crops from pests and diseases, and help improve crop yield and quality.
Furthermore, in the field of organic synthetic chemistry, due to its molecular structure containing chlorine atoms, nitro groups and imidazole rings, these functional groups give it unique reactivity and are often used as important building blocks for organic synthesis. With the help of various chemical reactions, its structure can be modified and derived, so as to obtain organic compounds with different properties and uses, providing a variety of options and possibilities for the development of organic synthetic chemistry.

2-Chloro-5-nitro-1H-imidazole is an organic compound with specific physical properties. It is a solid, either crystalline under normal conditions, or white to light yellow solid powder, with fine texture.
The melting point of this compound is quite important, about 190-195 ° C. The melting point is a material characteristic. At this temperature, the compound changes from solid state to liquid state. Before reaching the melting point, its molecules are arranged in an orderly manner according to the lattice. The increase of thermal energy causes the molecular vibration to intensify. At the melting point, the lattice disintegrates and the substance melts.
Its solubility is also a key physical property. In organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), etc., there is a certain solubility. Because these organic solvents are polar, they can form hydrogen bonds and dipole-dipole interactions with 2-chloro-5-nitro-1H-imidazole molecules, which help them disperse in solvents. However, the solubility in water is poor. Although water is a polar solvent, 2-chloro-5-nitro-1H-imidazole molecules have a large proportion of hydrophobic groups and have weak interaction with water molecules, so it is difficult to dissolve in water. < Br >
The density of 2-chloro-5-nitro-1H-imidazole is about 1.7 g/cm ³. The density reflects the mass per unit volume of the substance. This value indicates that the compound is relatively dense and closely related to the molecular structure. The atoms or groups such as chlorine and nitro in the molecule increase the mass per unit volume.
In terms of stability, it has certain stability to heat and light. However, in case of strong oxidizing agents, strong bases and other substances, the structure may be changed due to chemical reactions. Due to the certain activity of chlorine atoms in the molecule, the nitro group is a strong electron-absorbing group, which changes the electron cloud density of the imidazole ring and affects its chemical stability.

2-Chloro-5-nitro-1H-imidazole, this is an organic compound with interesting chemical properties and important research value.
As far as its stability is concerned, the presence of chlorine atoms and nitro groups in the molecule of 2-chloro-5-nitro-1H-imidazole affects its stability. Nitro is a strong electron-absorbing group, which will change the density distribution of molecular electron clouds and enhance molecular activity, resulting in a slight decrease in stability. Although chlorine atoms also have electron-absorbing effects, they are slightly weaker than nitro groups. The combination of the two makes the compound exhibit certain reactivity under specific conditions, and the stability is not very high.
In terms of acidity and alkalinity, this compound contains an imidazole ring. Theoretically, the nitrogen atom of the imidazole ring has a certain alkalinity, which can react with acids and accept protons to form salts. However, due to the electron-absorbing effect of chlorine atoms and nitro groups, the electron cloud density of nitrogen atoms will be weakened, resulting in a decrease in alkalinity. Therefore, 2-chloro-5-nitro-1H-imidazole has weak alkalinity and is difficult to reflect alkaline characteristics in common acid-base environments.
In addition to its solubility, 2-chloro-5-nitro-1H-imidazole is an organic compound. According to the principle of similar miscibility, it may have a certain solubility in organic solvents, such as common ethanol and acetone. However, due to the presence of polar groups in the molecule, it may also have very slight solubility in water, but overall, its solubility in water is poor.
In terms of chemical reactivity, due to the presence of nitro and chlorine atoms, the compound can undergo various reactions. Nitro is prone to reduction and can be reduced to amino groups under suitable conditions, which is an important conversion step in organic synthesis. Chlorine atoms can participate in nucleophilic substitution reactions, and many nucleophilic reagents can attack the carbon atoms attached to chlorine, causing chlorine atoms to be replaced, thereby constructing new organic compound structures.
In short, the specific structure of 2-chloro-5-nitro-1H-imidazoline presents unique chemical properties and may have important applications in organic synthesis and related fields.

The preparation method of 2-chloro-5-nitro-1H-imidazole is not contained in the ancient book Tiangong Kaiwu, but it can be described according to the current general method of chemical preparation.
First, imidazole is used as the starting material. Imidazole is first nitrified, and under appropriate reaction conditions, it is treated with a mixed acid system of concentrated nitric acid and concentrated sulfuric acid. This mixed acid system can nitrify imidazole, and nitro is introduced at its 5th position to generate 5-nitroimidazole. This reaction requires temperature control to prevent side reactions from occurring. Generally, the temperature control is at a moderate low temperature. Due to high temperature, it is easy to cause excessive nitrification or other side reactions.
Second, 5-nitroimidazole is chlorinated again. Suitable chlorination reagents can be selected, such as dichlorosulfoxide, phosphorus oxychloride, etc. Taking dichlorosulfoxide as an example, in a suitable solvent, such as toluene, etc., 5-nitroimidazole reacts with dichlorosulfoxide, and the hydrogen at the second position of the imidazole ring is replaced by chlorine atoms to generate 2-chloro-5-nitro-1H-imidazole. During the reaction process, attention should be paid to the reaction process, which can be monitored by thin-layer chromatography and other means. After the reaction is completed, it is post-processed, such as distillation to remove the solvent, recrystallization and other steps, to obtain a
Another way is to chlorinate imidazole first to obtain 2-chlorimidazole, and then introduce 5-nitro group by nitration reaction. However, this route needs to consider the selectivity of chlorination reaction and the effect of subsequent nitration on existing chlorine atoms. The reaction conditions also need to be carefully controlled to obtain the target product 2-chloro-5-nitro-1H-imidazole. During the preparation process, the reaction conditions at each step, such as temperature, reagent dosage, reaction time, etc., need to be carefully considered to improve the yield and purity.

In today's world, business conditions are unpredictable, and the price of 2-chloro-5-nitro-1H-imidazole in the market also fluctuates with many factors. Looking at the market conditions of the past, its price often changed due to supply and demand, materials, production methods, etc.
If the supply and demand are peaceful, the materials are easy to obtain, and the production method is stable, the price may be in a stable area. However, if materials are scarce, or the production method encounters obstacles, the supply will drop sharply, and the demand has not dropped, the price will rise. On the contrary, if the supply is abundant and the demand is weak, the price will decline.
In the past, the price of this product in the market may hover between tens of yuan and hundreds of yuan per kilogram. Due to differences in regions, different quality, and different transaction volumes, the price varies. In the prosperous capital of Dayi, the supply and demand are prosperous and the transaction is frequent, and the price may stabilize due to competition; in remote places, the supply and demand are limited and the logistics is inconvenient, and the price may be slightly higher.
And because of the quality, the price is also different. Refined high-quality products can meet the needs of high standards, and the price is usually the highest; ordinary quality is only for regular needs, and the price may be slightly lower. And the quantity of the transaction is also related to the price. Buy in bulk, and merchants may give discounts for promoting quantity, and the price is lower than that of zero purchases.
However, the market situation is impermanent, and if you want to know the exact price at present, you need to study the current supply and demand situation in detail, consult all merchants, and compare their quotations to obtain a near-real price.