2-CHLORO-4-NITRO-1H-IMIDAZOLE, 98+%

2-Chloro-4-nitro-1H-imidazole, with a content of more than 98%, has a wide range of uses. In the field of medicinal chemistry, it is often an important intermediate. Due to its unique structure, it can be converted into compounds with specific pharmacological activities through various chemical reactions, and can provide key starting materials for the development of antibacterial and antiviral drugs in the process of drug development.
In the field of materials science, it also has a place. It can participate in the synthesis of polymer materials. By introducing this group, it endows materials with unique properties such as special stability, electrical conductivity or optical properties, and helps to develop new functional materials.
In the field of organic synthesis, 2-chloro-4-nitro-1H-imidazole, as a highly active reaction substrate, can react with a variety of reagents for substitution, addition, etc., used to construct more complex and novel organic molecules, which contribute to the development of organic synthetic chemistry and play an important role in exploring the relationship between structure and properties of new organic compounds.

2-Chloro-4-nitro-1H-imidazole, with a content of more than 98%, its physical properties are as follows:
This substance is mostly in solid form at room temperature, and its appearance is usually a powdery or crystalline substance that is off-white to light yellow. Its melting point is about a specific range, but the exact value varies slightly due to slight differences in measurement conditions, and is roughly within a certain temperature range. The density of this substance is also an important physical property, reflecting its mass per unit volume, which is crucial for measuring and calculating the relevant quantity.
In terms of solubility, the solubility of 2-chloro-4-nitro-1H-imidazole in common organic solvents varies. In some polar organic solvents, such as methanol and ethanol, it can be dissolved to a certain extent, but the solubility is not very high; in non-polar organic solvents, such as n-hexane and petroleum ether, the solubility is poor, or even insoluble.
Its stability is also a consideration of physical properties. Under general environmental conditions, without special external factors, this substance can maintain a relatively stable state. In case of extreme conditions such as high temperature, open flame, or contact with specific chemical substances, chemical reactions may occur, causing changes in its chemical structure, which in turn affects its physical properties.
In addition, 2-chloro-4-nitro-1H-imidazole is also sensitive to light. Long-term exposure to light may cause photochemical reactions, causing changes in physical properties such as color and morphology. Therefore, when storing, it is often necessary to store it in a cool, dry and dark place to maintain its physical stability and ensure quality and performance.

2-Chloro-4-nitro-1H-imidazole, which has a purity of more than 98%. The chemical properties of this compound are relatively stable. Due to its molecular structure, the presence of chlorine atoms and nitro groups endows the molecule with a specific electron cloud distribution and spatial configuration.
The chlorine atom has an electron-sucking induction effect. The nitro group not only has a strong electron-sucking induction effect, but also has a conjugation effect. The synergistic effect of the two makes the electron cloud density on the imidazole ring decrease. In this case, the electrophilic substitution reactivity of the imidazole ring decreases, and it is not easy to be attacked by electrophilic reagents.
However, under certain conditions, it can also exhibit certain reactivity. For example, in a strongly alkaline environment and under the action of appropriate temperatures and catalysts, chlorine atoms can undergo substitution reactions and be replaced by other nucleophilic groups. Nitro groups can also participate in some reduction reactions, such as under the action of suitable reducing agents, nitro groups can be gradually reduced to amino groups.
Overall, in conventional storage and general chemical environments, 2-chloro-4-nitro-1H-imidazole can maintain a relatively stable chemical state. When encountering specific reaction conditions and reagents, its chemical activity can be revealed, and it can participate in a variety of organic synthesis reactions. It is an important synthetic intermediate in the field of organic chemistry.

2-Chloro-4-nitro-1H-imidazole, with a content of more than 98%. This is a chemical substance. When storing, many matters need to be paid attention to.
The first environment should be placed in a cool place. This substance is prone to change its properties due to heat, or cause chemical reactions. A cool environment can reduce its molecular level active and maintain its chemical stability. And it needs to be dry. If moisture invades it, it may cause reactions such as hydrolysis. Water molecules interact with the compound, or break its original structure, damaging its purity and quality.
Furthermore, open flames and hot topics should be avoided. 2-Chloro-4-nitro-1H-imidazole has a certain chemical activity, in case of open flame, hot topic, or flammable and explosive, endangering safety. In the storage place, fireworks are strictly prohibited, and electrical equipment should also be explosion-proof to prevent accidental explosion.
It should be stored separately from oxidizing agents, acids, bases, etc. Because of its special chemical structure, it comes into contact with the above substances or reacts violently. Oxidizing agents have strong oxidizing properties, which can seize the imidazole electrons and initiate oxidation reactions; acids and bases may change their ionic state, resulting in chemical changes.
In addition, storage containers are also exquisite. A sealed container is required to prevent its volatilization and prevent external substances from invading. The material used should not react with the compound, and glass, specific plastics and other materials may be suitable, depending on their chemical characteristics.
Daily management should not be ignored. Regular inspections should be made to see if its appearance changes, such as color, shape, etc. If there is any abnormality, quickly check the cause and take corresponding measures. And record the storage conditions, time and other information in detail for traceability and management. In this way, the safety and quality of 2-chloro-4-nitro-1H-imidazole storage can be guaranteed.

2-Chloro-4-nitro-1H-imidazole, with a content of more than 98%. The synthesis method is as follows:
To prepare 2-chloro-4-nitro-1H-imidazole, you can start from common starting materials. One method is to take imidazole as the starting material and nitrate it first. Place the imidazole in a suitable reaction vessel and add an appropriate amount of nitrifying reagent, such as the mixed acid of concentrated nitric acid and concentrated sulfuric acid. This mixed acid has strong oxidizing and nitrifying ability. Under the control of appropriate temperature and reaction time, nitrate can replace the hydrogen atom at a specific position on the imidazole ring to generate 4-nitroimidazole. This step requires careful temperature control to prevent side reactions from occurring and causing impurity of the product.
After 4-nitroimidazole is obtained, chlorination is carried out. Select suitable chlorination reagents, such as dichlorosulfoxide or phosphorus oxychloride. Mix 4-nitroimidazole with chlorination reagent. Under suitable reaction conditions, the chlorine atom in the chlorination reagent will replace the hydrogen at a specific position of 4-nitroimidazole to obtain 2-chloro-4-nitro-1H-imidazole. During the reaction process, it is necessary to pay attention to the pH of the reaction system, temperature and reaction time, which have a great impact on the yield and purity of the product. < Br >
There is another method. Compounds containing specific substituents can be selected as starting materials, and an imidazole ring can be constructed through multi-step reaction, and chlorine atoms and nitro groups can be introduced at the same time. For example, select suitable compounds containing nitrogen, carbon and halogen atoms, and gradually form an imidazole ring structure through condensation, cyclization and other reactions, and then modify it through nitrification and chlorination to achieve the purpose of generating 2-chloro-4-nitro-1H-imidazole. Although this route is a little complicated, it can be flexibly adjusted and optimized according to the availability of raw materials and the convenience of reaction conditions. After each step of the reaction, it needs to be separated and purified, such as extraction, recrystallization, column chromatography, etc., to obtain high-purity 2-chloro-4-nitro-1H-imidazole products.