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What is the chemical structure of 2-butyl-4-chloro-1- [p- (o-1h-tetrazol-5-ylphenyl) benzyl] imidazole-5-+methanol
This is the naming of an organic compound. To know its chemical structure, it is necessary to analyze it according to the naming rules. " In 2 - butyl - 4 - chloro - 1 - [p - (o - 1h - tetrazol - 5 - ylphenyl) benzyl] imidazole - 5 - methanol "," 2 - butyl "shows imidazole ring at 2-butyl;" 4 - chloro "has chlorine atom at table 4;" 1 - [p - (o - 1h - tetrazol - 5 - ylphenyl) benzyl] "means 1-bit is connected to a specific benzyl group, and the benzyl ring of this benzyl group is connected to an ortho-position containing 1H - tetrazole - 5 -Phenyl group of the group; "imidazole" is an imidazole ring; "5-methanol" refers to the 5-position methanol group.
According to this, its chemical structure is based on the imidazole ring as the core, with butyl extension at 2 positions, chlorine atoms at 4 positions attached, benzyl groups at 1 position connected to specific phenyl structures, and methanol groups at 5 positions. The imidazole ring has a conjugated system and has good stability. Butyl is a saturated hydrocarbon group with certain hydrophobicity. The electronegativity of the chlorine atom affects the polarity and reactivity of the molecule. The complex phenyl structure connected at 1 position, the tetrazole group can participate in a variety of reactions, and the conjugation between benzene rings has a great impact on the distribution of molecular electron clouds and physical and The 5-position methanol group contains hydroxyl groups, which can participate in the formation of hydrogen bonds and many organic reactions. Therefore, this compound has a unique structure and its properties are synergistically shaped by various groups. It may have specific uses and reactivity in the fields of organic synthesis, medicinal chemistry, etc.
What are the physical properties of 2-butyl-4-chloro-1- [p- (o-1h-tetrazol-5-ylphenyl) benzyl] imidazole-5-+methanol
2-Butyl-4-chloro-1- [p- (o-1H-tetrazolium-5-ylphenyl) benzyl] imidazole-5-methanol, this is an organic compound. Looking at its structure, it contains various groups such as butyl, chlorine atom, imidazole ring, benzyl and tetrazolophenyl. The structure is complex, and the interaction between groups affects its physical properties.
First talk about the appearance, usually these organic compounds are mostly white to light yellow crystalline powders. Because of its certain symmetry and regular molecular arrangement, the crystallization tendency is significant, and the powder form is also easy to handle and store.
Let's talk about the melting point. In view of the various interactions such as hydrogen bonds and van der Waals forces in the molecule, the molecular binding is close, and the melting point is generally quite high, between about 150 ° C and 200 ° C. It is necessary to borrow a precision melting point tester and accurately determine it by capillary method. Factors such as the heating rate during measurement have a great influence on the results.
In terms of solubility, the compound contains polar imidazole rings, hydroxyl groups, and non-polar butyl, benzyl and other groups. Therefore, in polar organic solvents such as methanol, ethanol, and dichloromethane, it has a certain solubility due to the principle of similar miscibility; in water, due to the large proportion of non-polar groups, the solubility is poor. < Br >
In terms of stability, the imidazole ring is relatively stable, but the chlorine atom has high activity. Under specific conditions, such as high temperature, strong acid-base or catalyst, it is prone to substitution reactions. The tetrazole group also has certain reactivity, and may change in case of strong oxidizing agents. When storing, it should be placed in a cool, dry and dark place to prevent decomposition and deterioration.
Density determination is crucial, related to its application in different systems. It can be measured by the pictogram method or a densitometer. Its density is slightly higher than that of water, about 1.2-1.4 g/cm ³. Due to the compact molecular structure, the mass per unit volume is large. < Br >
The physical properties of this compound are affected by the synergistic effect of various groups in the structure, and its properties determine the application direction and prospect in the fields of organic synthesis and drug development.
What is the use of 2-butyl-4-chloro-1- [p- (o-1h-tetrazol-5-ylphenyl) benzyl] imidazole-5-+methanol
2 - butyl - 4 - chloro - 1 - [p - (o - 1h - tetrazol - 5 - ylphenyl) benzyl] imidazole - 5 - methanol, this is an organic compound with a wide range of uses. In the field of medicine, it is often used as an active pharmaceutical ingredient or intermediate. Due to its special structure, it has specific biological activities and can interact with many targets in organisms, such as specific proteins, enzymes or receptors.
In the process of drug development, this compound is used as a starting material and chemically modified and optimized to create new drugs for the treatment of various diseases. For example, it may be possible to develop specific drugs for cardiovascular diseases, tumors or neurological diseases by adjusting its structure to enhance its affinity and selectivity for specific disease-related targets.
In the field of materials science, the compound may be used to prepare materials with special properties. Due to its unique chemical structure, it may impart special properties such as optical, electrical or thermal properties to materials. For example, it can be introduced into polymer materials to improve the mechanical properties, stability or functionality of materials, so as to be used in the manufacture of electronic devices, optical materials or high-performance polymers.
In addition, in organic synthetic chemistry, it is an important intermediate and participates in the construction of a series of complex organic molecules. Chemists can ingeniously design reaction paths and take advantage of the activity check point of this compound to realize the preparation of other difficult-to-synthesize organic compounds, which contributes to the development of organic synthetic chemistry and promotes the creation and research of new compounds.
What are the synthesis methods of 2-butyl-4-chloro-1- [p- (o-1h-tetrazol-5-ylphenyl) benzyl] imidazole-5-+methanol
The synthesis method of 2-butyl-4-chloro-1-[ p- (o-1H-tetrazolium-5-ylphenyl) benzyl] imidazole-5-methanol has been known for a long time, but people at present want a new method to achieve good.
Past methods, or imidazole-based, are obtained by multi-step reaction. Take imidazole first, make it with suitable halogenated hydrocarbons, such as butyl-containing halogens, in suitable solvents, such as alcohols, and carry out nucleophilic substitution reactions with bases as catalysts to obtain imidazole derivatives containing butyl.
Then, the derivative is used as the substrate and reacted with the chlorine-containing reagent under specific conditions to introduce chlorine atoms. This step requires precise control of the reaction temperature and time to prevent side reactions.
Furthermore, the fragment of p- (o-1H-tetrazolium-5-ylphenyl) benzyl is synthesized, mostly with benzene as the starting material, and the desired fragment is finally obtained through multi-step functional group transformation, such as halogenation, cyanidation, hydrolysis, cyclization and other reactions.
Finally, the imidazole derivative containing butyl and chlorine, and the p- (o-1H-tetrazolium-5-ylphenyl) benzyl fragment, under suitable reaction conditions, undergoes condensation reaction to form the target product precursor, and then through reduction steps, 2-butyl-4-chloro-1 - [p-1H-tetrazolium-5-ylphenyl) benzyl] imidazole-5-methanol can be obtained.
Nowadays, science and technology are changing day by day, and synthetic methods guided by the concept of green chemistry are also being explored, in order to achieve the synthesis of this compound in a more environmentally friendly and efficient way. Such as the use of new catalysts, or the development of mild reaction conditions to reduce energy consumption and waste generation, these are the directions that everyone is striving to move forward on the road of synthesis.
What is the safety information of 2-butyl-4-chloro-1- [p- (o-1h-tetrazol-5-ylphenyl) benzyl] imidazole-5-+methanol
I think this "2 - butyl - 4 - chloro - 1 - [p - (o - 1h - tetrazol - 5 - ylphenyl) benzyl] imidazole - 5 - + methanol" is a complex chemical substance. However, regarding its safety information, I will describe it in ancient literature.
The impact of these chemicals on the human body is still unknown. Or toxicological changes, after entering the body, it may disturb the operation of qi and blood, and disrupt the functions of the viscera. If ingested by mistake, it may cause gastrointestinal diseases, abdominal pain, vomiting, etc.
If the volatile gas enters the mouth and nose, it may damage the lung meridian, cause dyspnea, cough, asthma or present. There is also a risk that the skin will touch it, or cause redness, swelling, itching, and the disease of sores.
In the environment, if this substance is discarded at will, it may damage the sewage and soil, and damage the life of plants and trees. Although there is no detailed evidence, it is common sense to infer that this complex chemical should be used with caution. When using, when following strict procedures, it should be well protected, and it should not be slightly damaged, so as not to endanger yourself and the peace of the surroundings. When preparing and storing, it should also strictly abide by the laws to prevent it from leaking and escaping, so that the security is safe.