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What are the physical properties of 2-Bromo-4-methyl-1H-imidazole?
2-Bromo-4-methyl-1H-imidazole is also an organic compound. It has unique physical properties, which are related to the state, melting point, boiling point, solubility and density of the substance.
This substance is mostly in a solid state at room temperature, which is caused by the force between molecules. As for the melting point, it is about a specific numerical range, due to the arrangement and interaction of atoms in the molecular structure. When heated to this melting point, the molecule is energized and the movement intensifies, the lattice structure disintegrates, and then the solid state is transferred to the liquid state.
The boiling point is also an important physical property. It requires a certain temperature and pressure to change the substance from the liquid state to the gaseous state. The boiling point of 2-bromo-4-methyl-1H-imidazole is affected by intermolecular attractive forces, such as van der Waals forces and hydrogen bonds. If the intermolecular attractive force is strong, higher energy is required to overcome it, and the boiling point also rises.
In terms of solubility, it is different from different solvents. In polar solvents, because the molecules have a certain polarity, they are partially soluble. Polar solvents and solute molecules can form a dipole-dipole interaction to help them dissolve. In non-polar solvents, the solubility is poor because the intermolecular forces do not match.
Density, characterizing the mass per unit volume. The density of 2-bromo-4-methyl-1H-imidazole is determined by the mass of its molecules and the way of packing. If the molecular weight is large and the packing is tight, the density is higher.
All kinds of physical properties are of key significance for its synthesis, separation and application in different fields. Researchers need to know these properties in detail in order to make good use of them. In chemical synthesis, drug development and many other aspects, it is also the basis.
What are the chemical properties of 2-Bromo-4-methyl-1H-imidazole?
2 - Bromo - 4 - methyl - 1H - imidazole is an organic compound with unique chemical properties, which is worth studying.
This compound contains bromine atoms and methyl groups, giving it special reactivity. Bromine atoms are key check points in many reactions due to their electronegativity. For example, nucleophilic substitution reactions can occur, and halogen atoms bromine are easily replaced by nucleophiles. With this reaction property, chemists can introduce diverse functional groups and expand the path of organic synthesis, which is of great significance in the fields of medicine and material synthesis.
Furthermore, 1H - imidazole rings have electron-rich properties and can participate in various electron transfer processes and cyclization reactions. The electron cloud distribution on the ring caused by its conjugated structure is unique, which makes the compound exhibit certain basicity and coordination ability. Under specific conditions, it can coordinate with metal ions to form complexes, which can play a role in the field of catalysis or materials science. The methyl group at the
4-position also affects the physical and chemical properties of the compound. Methyl group is the power supply, which can change the electron cloud density of the imidazole ring, which in turn affects the reactivity and selectivity. From the perspective of physical properties, the presence of methyl group can affect the intermolecular forces, change the melting point, boiling point and solubility of the compound.
2 - Bromo - 4 - methyl - 1H - imidazole exhibits rich chemical properties due to its unique chemical structure, and has broad research and application prospects in organic synthesis, coordination chemistry and related application fields.
What are the common synthetic methods of 2-Bromo-4-methyl-1H-imidazole?
The common synthesis methods of 2-bromo-4-methyl-1H-imidazole cover many ways. First, 4-methyl-1H-imidazole is used as the starting material and obtained by bromination reaction. Among them, liquid bromine or N-bromosuccinimide (NBS) are often brominating reagents. If liquid bromine is used, liquid bromine should be slowly added dropwise in a suitable solvent, such as dichloromethane and chloroform, under low temperature conditions, and stirred at the same time. Because liquid bromine is active and the reaction is violent, temperature control is very critical to prevent side reactions from breeding. If NBS is used, the reaction is relatively mild, and it is usually heated in a suitable solvent such as carbon tetrachloride in the presence of an initiator, such as benzoyl peroxide. After the reaction is completed, the pure product can be obtained by separation and purification methods, such as column chromatography, recrystallization, etc.
Second, the imidazole ring is gradually constructed from a suitable nitrogen-containing and carbon-containing precursor, and bromine and methyl are introduced. For example, using 1,2-dicarbonyl compounds, methylamine and brominating reagents as raw materials, it is synthesized through a multi-step reaction. First, the 1,2-dicarbonyl compounds are condensed with methylamine to form an intermediate product, and then bromine atoms are introduced and the ring is closed to form an imidazole ring. There are many steps in this path, but the regulation requirements of the reaction conditions are also high. The yield and selectivity of each step of the reaction are related to the yield and purity of the final product. After each step of the reaction, fine separation and purification are required to remove impurities before the reaction can proceed as expected, and the final product is 2-bromo-4-methyl-1H-imidazole.
2-Bromo-4-methyl-1H-imidazole in what areas?
2-Bromo-4-methyl-1H-imidazole is useful in various fields. In the field of medicine, this compound is a key intermediate for the synthesis of a variety of drugs. Because of its unique structure, it can be combined with specific targets in the body, so it can be used to create drugs with antibacterial, antiviral, anti-tumor and other effects. Doctors can refine the formula according to its characteristics to cure all diseases.
In the field of materials science, 2-bromo-4-methyl-1H-imidazole also has extraordinary performance. It can be used as a ligand to complexe with metal ions to construct metal-organic framework materials (MOFs) with excellent performance. Such materials have significant advantages in gas adsorption and separation, catalytic reactions, etc., and can be used to purify air, separate mixed gases, and improve industrial production efficiency.
Furthermore, in the field of organic synthetic chemistry, it is an important synthetic building block. Chemists can build complex and diverse organic molecular structures on the basis of various organic reactions. Through halogenation reactions, substitution reactions, etc., many new compounds have been derived, expanding the variety of organic compounds, and opening up new paths for chemical research and application.
And in the field of agriculture, or can be used as pesticide intermediates to create pesticide products with high insecticidal and bactericidal properties. It can accurately act on crop diseases and pests, ensure the healthy growth of crops, improve food production, and protect the food of all people. Overall, 2-bromo-4-methyl-1H-imidazole plays a key role in many fields such as medicine, materials, organic synthesis, and agriculture, promoting the development and progress of various industries.
What is the market price of 2-Bromo-4-methyl-1H-imidazole?
Today there is 2-bromo-4-methyl-1H-imidazole. What is the market price of this product? This is a fine chemical, and its price often changes due to multiple reasons. First, the quantity is small. If the purchase quantity is quite large, the seller may give a profit, and the price will be low; if the quantity is small, the price will be high. Second, the quality is good. If the quality is good, pure and less miscellaneous, the price will be high; if the quality is poor, the price will be low. Third, the source is different. It is produced by a famous factory, and its research and production are fine, and the price is also high; if it is produced by a small factory, the price will be low.
Furthermore, the supply and demand of the market are also the main reasons. There are many people in need, and there are few suppliers, so the price must go up; if the supply exceeds the demand, the price will drop.
Under the current market, the price of 2-bromo-4-methyl-1H-imidazole ranges from a few yuan to a few tens of yuan per gram. However, this is only an approximate number. To know the exact price, you should consult the chemical raw material supplier or check it on the chemical trading platform to get a near-real price.