2-benzyl-1H-benzimidazole

2-Benzyl-1H-benzimidazole, this is an organic compound. It has a wide range of uses and is often a key intermediate in the synthesis of drugs in the field of medicinal chemistry. Gein-benzimidazole compounds have various biological activities, such as antibacterial, antiviral, antitumor, etc. 2-Benzyl-1H-benzimidazole can be modified and reacted in a specific way, or can generate drug molecules with specific pharmacological activities for the treatment of diseases.
In the field of materials science, it also has applications. Due to its structural properties, it may participate in the preparation of functional materials, such as optoelectronic materials. After rational design and synthesis, materials containing 2-benzyl-1H-benzimidazole structures may have unique optical and electrical properties, which show potential in the fields of optoelectronic devices such as Light Emitting Diodes and solar cells.
Furthermore, in organic synthetic chemistry, 2-benzyl-1H-benzimidazole is often used as a building block for organic synthesis. With its activity check point of benzimidazole ring and benzyl group, it can construct more complex organic molecular structures through various chemical reactions, such as nucleophilic substitution, redox, etc., expand the types and properties of organic compounds, and contribute to the development of organic synthetic chemistry.

To prepare 2-benzyl-1H-benzimidazole, there are two methods. One is to use o-phenylenediamine and benzoic acid as raw materials. First take an appropriate amount of o-phenylenediamine, place it in a clean reaction vessel, and then add benzoic acid. The molar ratio of the two needs to be carefully considered, usually about 1:1 to 1:1.2. Then, add an appropriate amount of catalyst, such as concentrated sulfuric acid or p-toluenesulfonic acid, in an amount of about 1% to 5% of the total mass of the reactants. Heat in an oil bath or sand bath, and slowly raise the temperature to 180-220 ° C. At this high temperature, continue to stir and react for 3-6 hours. After the reaction is completed, when it cools, the product is recrystallized with ethanol or ethyl acetate to obtain pure 2-benzyl-1H-benzimidazole.
The second is to use o-nitroaniline and benzonitrile as starting materials. First, put o-nitroaniline and benzonitrile in a certain ratio, such as 1:1.5 - 1:2, in a high-pressure reactor, and then add an appropriate amount of metal catalyst, such as palladium carbon or Raney nickel, in an amount of about 3% - 8% of the total mass of the reactant. Inject an appropriate amount of hydrogen to make the pressure in the kettle reach 3-5 MPa. Warm up to 120-150 ° C and stir the reaction under this condition for 8-12 hours. After the reaction was completed, the catalyst was filtered out and the filtrate was purified by decompression distillation and column chromatography, and 2-benzyl-1H-benzimidazole was obtained.

2-Benzyl-1H-benzimidazole, this is an organic compound with unique physical properties. It is a solid under normal conditions, but its specific appearance may vary depending on the purity and preparation method. It is mostly white to light yellow powder, with a fine texture, just like the lightness of early winter snow.
The melting point is an important physical property of the substance. The melting point of 2-benzyl-1H-benzimidazole is about 130-135 ° C. When the temperature gradually rises near the melting point, its lattice structure gradually loosens, and the molecular thermal motion intensifies, just like sleeping molecules are awakened, begin to dance actively, and eventually melt from solid to liquid.
Its solubility is also worthy of attention. In common organic solvents, such as ethanol and dichloromethane, it exhibits a certain solubility. In ethanol, just like fish entering water, some molecules are uniformly dispersed to form a uniform and stable solution. However, in water, the solubility is poor. Because of its molecular structure, there are fewer hydrophilic groups and more hydrophobic parts. It seems that oil and water are incompatible, and it is difficult to dissolve a large amount in water.
2-benzyl-1H-benzimidazole also has certain stability. Under normal temperature and pressure and ordinary environmental conditions, it can maintain its own structure and properties stable, just like a calm old man, who is not surprised. However, in extreme chemical environments such as strong oxidizing agents and strong acids and bases, its structure may be damaged, triggering chemical reactions and changing its original properties.
The physical properties of this compound have far-reaching implications for its applications in organic synthesis, drug development and other fields. For example, in drug development, properties such as melting point and solubility are related to the drug preparation process and absorption effect in vivo. Only by understanding its physical properties can we better control its application and maximize its value.

2-Benzyl-1H-benzimidazole, this is an organic compound with unique chemical properties. It is white to light yellow crystalline powder, soluble in common organic solvents such as ethanol and chloroform, but insoluble in water.
In terms of chemical activity, the benzimidazole ring system of 2-benzyl-1H-benzimidazole is very stable, but due to the presence of benzyl, it has a certain reactivity. The methylene on the benzyl group can undergo a substitution reaction, such as halogenation reaction. Under appropriate conditions, halogens can replace the hydrogen atom of the methylene group.
Furthermore, the nitrogen atom of the benzimidazole ring has a lone pair of electrons, is basic, and can react with acids to form salts. This property has attracted much attention in the field of medicinal chemistry, because it can improve the solubility and stability of compounds through salt formation.
At the same time, 2-benzyl-1H-benzimidazole can participate in a variety of organic synthesis reactions, such as reacting with carbonyl compounds such as aldose and ketone to form nitrogen-containing heterocyclic derivatives, which are quite useful in constructing complex organic molecular structures. < Br >
Its spectral properties also have characteristics. In infrared spectroscopy, benzene ring, methylene and nitrogen-hydrogen bonds all have corresponding absorption peaks, which can provide a basis for structure identification; in nuclear magnetic resonance spectroscopy, hydrogen and carbon atoms at different positions have unique chemical shifts, which help to determine the spatial structure of molecules.
In summary, 2-benzyl-1H-benzimidazole has rich chemical properties and has important application value in many fields such as organic synthesis and drug development.

The price range of 2-benzyl-1H-benzimidazole in the market is difficult to determine. The price of this product often varies due to various reasons, such as the source of production, the quality of the product, and the supply and demand of the market.
If the source is widely available and abundant, the quality is average and the market is sufficient, and the demand is few, the price may be cheap, ranging from a few yuan to a few tens of yuan per gram. However, if the source is narrow, the system is difficult, the quality is high and the market is prosperous, the price will be high, or hundreds of yuan per gram, or even more.
Also, the way of purchase is also involved in the price. From ordinary commercial purchases, the price may be relatively average; if you ask for special supplies, or for special needs, the price is often high.
Today's market conditions are changeable, and prices vary from time to time. If you want to know the exact price, you can get a more accurate number when you carefully observe the current market conditions and consult the merchants. Therefore, if you want to know the exact price of 2-benzyl-1H-benzimidazole, you can't get it without visiting the market in person and studying the market carefully.