2-AMino-1-Boc-iMidazole

2-AMino-1-Boc-iMidazole (2-AMino-1-Boc-iMidazole) has a wide range of uses. It plays an important role in the field of pharmaceutical synthesis. It is often used as a key intermediate for the preparation of various bioactive compounds. In some drug development processes, with the help of the unique structural characteristics of this compound, molecular structures that fit specific targets can be constructed, thus paving the way for the birth of innovative drugs.
In the field of organic synthesis, it is also an extremely important building block. It can participate in multiple complex organic reactions with its special reactivity of amino and tert-butoxycarbonyl. By cleverly reacting with other organic reagents, the construction of carbon-nitrogen bonds and carbon-carbon bonds is realized, which helps to synthesize organic molecules with complex structures. This compound can participate in many classical organic reactions, such as nucleophilic substitution, cyclization, etc., which greatly expands the possibility of organic synthesis and provides strong support for the creation of new organic materials and the total synthesis of natural products. In short, 2-amino-1-tert-butoxycarbonyl imidazole plays an indispensable role in the field of medicine and organic synthesis, promoting the continuous development and progress of related fields.

To prepare 2-amino-1-tert-butoxycarbonyl imidazole, imidazole can be used as the starting point and obtained through multi-step reaction. First, the t-butoxycarbonylation reaction is carried out with imidazole and a t-butoxycarbonylation reagent such as di-tert-butyl dicarbonate (Boc 2O O) in a suitable solvent such as dichloromethane, catalyzed by adding a base such as triethylamine. This step is intended to protect the imidazole nitrogen atom to obtain 1-tert-butoxycarbonyl imidazole. During the reaction, the temperature is controlled at a low temperature, such as 0 ° C to room temperature, fully stirred, and the reaction progress is monitored by TLC. When the raw material is almost The organic phase was separated by extraction with water and organic solvent. The organic phase was dried and evaporated to obtain the crude product of 1-tert-butoxycarbonyimidazole, which was purified by column chromatography to obtain the purified product.
Nitration reaction of 1-tert-butoxycarbonyimidazole is performed at times. Using mixed acids (nitric acid and sulfuric acid) as nitrifying reagents, slowly add mixed acids to 1-tert-butoxycarbonyimidazole at low temperatures such as -10 ° C to 0 ° C. In the organic solvent solution, such as in dichloromethane solution. During the reaction, closely monitor the temperature to prevent side reactions from occurring due to sudden temperature rise. After the reaction is completed, the reaction is quenched by hydrolysis of ice, and then extracted in an organic solvent, washed with water, dried, and evaporated to obtain a product containing nitro groups.
Then the nitro group is reduced to an amino group. A suitable reducing agent, such as hydrogen and palladium-carbon (Pd/C) catalyst system, can be used to react in an alcohol solvent such as methanol under normal pressure or pressure. During the reaction, ensure that the hydrogen supply is stable and the temperature is controlled in a moderate range, such as 25 ° C to 50 ° C. After the reaction is completed, the catalyst is filtered off, and the filtrate is evaporated to obtain a crude product of 2-amino-1-tert-butoxycarbonyl imidazole. It is further purified by recrystallization or column chromatography to obtain the target product.

I think what you are asking is about the market price of 2-amino-1-tert-butoxycarbonyl imidazole. However, the price of this chemical often changes due to many factors, and it is difficult to determine the exact value.
Its price fluctuations are mainly related to market supply and demand. If there are many people who want it, but the supply is small, the price will rise; conversely, if the supply exceeds demand, the price may fall. Furthermore, the cost of raw materials is also the key. If the price of the raw materials used to synthesize this imidazole is high, the price of the finished product will also be high; if the price of raw materials decreases, the price of the finished product may decrease accordingly.
The difficulty of the production process also affects its price. If the process is complex, it requires a lot of manpower, material resources and time, the cost increases, and the price increases; if the process is simple, the cost may be low, and the price will also be lower.
In addition, different suppliers set different prices due to their different business strategies and production costs. To know the exact market price, you need to consult chemical raw material suppliers, chemical reagent sales platforms, or relevant forums and information platforms in the chemical industry to observe the recent trading conditions.

2-Amino-1-tert-butoxycarbonyl imidazole, this is an important compound in organic chemistry. Its physical and chemical properties are quite critical, let me elaborate.
Looking at its physical properties, under normal conditions, it is mostly in the state of white to quasi-white crystalline powder. This compound is relatively stable at room temperature, and may decompose at high temperatures. Its melting point is also an important characterization, about a specific temperature range. This temperature range has been accurately determined by many experiments, which can provide important reference for subsequent research and applications.
As for chemical properties, the presence of amino and tert-butoxycarbonyl in this compound gives it unique reactivity. The amino group has a certain alkalinity and can neutralize with acids to form corresponding salts. Tert-butoxycarbonyl is a protective group and plays an extraordinary role in organic synthesis. Under specific conditions, t-butoxycarbonyl can be selectively removed, allowing the amino group to participate in subsequent more complex reactions, such as nucleophilic substitution with halogenated hydrocarbons to form new nitrogen-containing organic compounds. In addition, the imidazole ring of the compound also has certain aromatic properties and can participate in various electrophilic substitution reactions, such as halogenation, nitrification, etc.
The physicochemical properties of this compound are of great significance in the fields of medicinal chemistry, materials science, etc. In medicinal chemistry, complex drug molecular structures can be constructed by its reactivity; in materials science, its unique properties may facilitate the development of new functional materials. Therefore, in-depth understanding of its properties is the key to promoting the development of related fields.

2-Amino-1-tert-butoxycarbonyl imidazole is a key intermediate commonly used in fine organic synthesis. During storage and transportation, many matters need to be paid attention to to to ensure its quality and stability.
The first thing to pay attention to is the storage temperature. This compound should be stored in a low temperature environment, usually 2-8 ° C. If the temperature is too high, it is easy to cause decomposition reactions, which can damage the structure and reduce its activity. Just like the need to hide ice in a cellar in winter to keep it from melting, this compound also needs to be protected at low temperature to maintain its properties for a long time.
Secondly, moisture protection is extremely important. Because of its certain hygroscopicity, once damp, it will not only affect the purity, but also may cause side reactions such as hydrolysis. Therefore, it is necessary to ensure that the environment is dry when storing. It can be placed in a dryer with a desiccant inside, just like the ancients used lime to prevent moisture and keep the storage environment dry.
Furthermore, avoid light. Light will prompt photochemical reactions and change the chemical structure. It should be stored in a brown bottle or in a dark place, just like treasures hidden in a dark room, protected from light.
When transporting, the packaging should be firm and reliable. Due to its relatively lively nature, bumps and vibrations may cause danger. Packaging materials should have cushioning properties, such as wrapping in foam, like escorting fragile porcelain, be careful. At the same time, the transportation process should also maintain suitable temperature and humidity conditions, and should not be slack.
In addition, relevant regulations and standards must be followed. Whether it is storage or transportation, it should be strictly operated in accordance with regulations, and labels and records should be made for inspection. In this way, 2-amino-1-tert-butoxycarbonyl imidazole can be safely stored and transported.