2-{[(4-methoxy-3-methylpyridin-2-yl)methyl]sulfinyl}-6-(1H-pyrrol-1-yl)-1H-benzimidazole

This is the chemical structure of 2- {[ (4-methoxy-3-methylpyridine-2-yl) methyl] sulfinyl} -6- (1H-pyrrole-1-yl) -1H-benzimidazole. Its structure contains the core skeleton of benzimidazole, which is an important heterocyclic structure with diverse biological activities. The hydrogen atom of 1H-benzimidazole at the first position is replaced by a specific group.
Looking at its side chain, there is a complex group connected to the second position, namely {[ (4-methoxy-3-methylpyridine-2-yl) methyl] sulfinyl}. Here, 4-methoxy-3-methylpyridine-2-yl is connected to the sulfinyl group through methylene, and the sulfinyl group is connected to the 2-position carbon of benzimidazole. Methoxy and methyl are respectively connected to specific positions of the pyridine ring, which affects the electron cloud distribution and spatial hindrance of the molecule.
Furthermore, the 6-position is connected with 1H-pyrrole-1-yl, and the pyrrole ring is connected to the 6-position carbon of benzimidazole through the 1-position nitrogen atom. The pyrrole ring, as an electron-rich five-membered heterocycle, endows the molecule with unique electronic properties and reactivity.
The interaction of various parts of this chemical structure affects the physical, chemical and biological properties of the compound, and may have potential applications in the fields of medicinal chemistry, materials science, etc.

2-% 7B% 5B% 284-methoxy-3-methylpyridine-2-yl% 29methyl% 5Dsulfinyl% 7D-6- (1H-pyrrole-1-yl) -1H-benzimidazole, which has a wide range of uses in the medical tract.
In epigastric diseases, it can regulate the secretion of gastric acid. Diseases that cover the epigastric region are mostly caused by loss of gastric acid and corrosion of the inner wall of the epigastric region. This medicine can act on the proton pump of the cells in the gastric wall, preventing it from secreting acid into the gastric cavity, reducing the amount of gastric acid, stabilizing the epigastric environment, and relieving epigastric pain, pantothenic acid, heartburn and other diseases. It is often used in the treatment of epigastric ulcers, gastritis and other diseases.
It is also effective in the disease of esophageal reflux. In esophageal reflux, the contents of the stomach reflux into the esophagus, burning the esophageal mucosa. Because stomach acid is the culprit, this medicine controls acid, can reduce the irritation of the esophagus, reduce discomfort, and relieve symptoms such as retrosternal burning and dysphagia. It can also help the esophageal mucosa repair.
In addition, it also has a place in the related diseases of Helicobacter pylori infection. Although it is not a direct drug to kill Helicobacter pylori, it can create an environment that is not suitable for the survival of bacteria. Because Helicobacter pylori likes acid, this drug reduces stomach acid and destroys its survival microenvironment. In combination with antibiotics, it can increase the effect of sterilization and promote the improvement of related diseases.

To prepare 2- {[ (4-methoxy-3-methylpyridine-2-yl) methyl] sulfinyl} -6- (1H-pyrrole-1-yl) -1H-benzimidazole, the method is as follows:
First, take 4-methoxy-3-methylpyridine-2-formaldehyde, and a suitable thiol reagent, such as sodium methanethiol, in a suitable solvent, such as N, N-dimethylformamide (DMF), under the catalysis of a base, such as potassium carbonate, heat and stir to cause nucleophilic addition reaction, To obtain intermediates containing sulfide structure. This step requires temperature control and time control to ensure complete reaction and few side reactions.
times, the above sulfide intermediates are oxidized with an appropriate oxidant, such as m-chloroperoxybenzoic acid (m-CPBA), in an organic solvent, such as dichloromethane, under low temperature conditions, such as 0-5 ° C, and the sulfide is oxidized to sulfoxide. The key intermediate is 2 - {[ (4-methoxy-3-methylpyridine-2-yl) methyl] sulfinyl} -1H -benzimidazole.
Finally, take the above key intermediates, and 1-halogenated pyrrole, such as 1-chloropyrrole, in the presence of alkali and metal catalysts, such as cesium carbonate and cuprous iodide, in N-methylpyrrolidone (NMP) solvent, heating reaction, through nucleophilic substitution reaction, so that pyrrolidine is connected to benzimidazole at the 6-position, to obtain the target product 2 - {[ (4-methoxy-3-methylpyridine-2-yl) methyl] sulfinyl} -6- (1H-pyrrole-1-yl) -1H-benzene And imidazole. After each step of the reaction, the product needs to be purified by extraction, column chromatography, etc. to maintain purity and then promote subsequent reactions.

2-%7B%5B%284-methoxy-3-methylpyridin-2-yl%29methyl%5Dsulfinyl%7D-6-%281H-pyrrol-1-yl%29-1H-benzimidazole, this is an organic compound with specific physical properties. Under normal conditions, or as a solid, the cap is caused by the interaction between atoms in its molecular structure, resulting in an orderly arrangement of molecules and a solid state. Looking at its melting point, it is about a specific temperature range. Depending on the strength of the interaction between molecules, it is necessary to absorb a certain amount of heat to disintegrate the lattice structure and cause the solid state to turn to liquid.
Discuss solubility, in organic solvents, or exhibit different solubility characteristics. In polar organic solvents, such as ethanol and acetone, due to the presence of polar groups in the molecular structure, hydrogen bonds or other intermolecular forces can be formed with polar solvent molecules, so there is a certain solubility. However, in non-polar solvents, such as n-hexane, due to the large polar difference, the intermolecular force is weak, and the solubility may be extremely low.
In addition, its appearance may be white or off-white powder, which is related to its crystal morphology and particle size. The powder morphology is advantageous to increase its specific surface area, which can accelerate the contact and reaction rate between substances during chemical reactions or preparations.
Its density is also a specific value, reflecting the degree of tight packing of molecules. The density is affected by molecular structure, crystal form and other factors, and plays an important role in its dispersion and sedimentation in different media.
In addition, the stability of the compound may be relatively stable under specific conditions. However, under extreme conditions such as high temperature, strong acid and strong base, the chemical bonds in the molecular structure may be affected, and reactions such as fracture or rearrangement occur, resulting in changes in its chemical properties.
In summary, the physical properties of 2-%7B%5B%284-methoxy-3-methylpyridin-2-yl%29methyl%5Dsulfinyl%7D-6-%281H-pyrrol-1-yl%29-1H-benzimidazole are of great significance in the fields of chemical research, drug development and industrial production, and help researchers understand their characteristics and apply them rationally.

2-% 7B% 5B% 284-methoxy-3-methylpyridine-2-yl% 29methyl% 5Dsulfinyl% 7D-6- (1H-pyrrole-1-yl) -1H-benzimidazole This product is worth exploring in today's market prospects.
In the field of Guanfu Medicine, such compounds containing benzimidazole structures often have unique biological activities. In terms of proton pump inhibitors, their structures may be similar to them, and proton pump inhibitors have long been in the market for anti-ulcer drugs. If this compound also has the ability to inhibit acid and can prevent various diseases caused by excessive gastric acid, such as gastric ulcer, duodenal ulcer, etc., it should have a wide world in the digestive medicine market.
In addition, it contains special substituents, such as 4-methoxy, 3-methylpyridyl and pyrrolyl, etc., or it can be given different pharmacological properties, or it can be developed into novel therapeutic drugs to meet unmet clinical needs. This is also a big opportunity for market development.
However, there are also obstacles to its entry into the market. The development of new drugs requires a lot of trials, from laboratory research, animal testing, and even human clinical trials. There are many obstacles, which cost a lot of money and take a long time. And there are already many anti-ulcer and related drugs in the market, and the competition is fierce. To gain a place in this market, it is necessary to highlight its unique advantages, such as better efficacy and fewer side effects.
Overall, 2-% 7B% 5B% 284-methoxy-3-methylpyridine-2-yl% 29methyl% 5Dsulfinyl% 7D-6- (1H-pyrrole-1-yl) -1H-benzimidazole Although facing challenges, with its potential pharmacological activity, if the research and development goes well, it may emerge in the pharmaceutical market and achieve great results.